The team then introduced short RNA molecules that deactivate a gene called Id1, which promotes angiogenesis and is active
in endothelial progenitors.
Not exact matches
A critical discovery
in this research was finding that the novel
progenitor has a receptor protein on its cell surface called KDR, or vascular
endothelial growth factor receptor 2, which until now, was thought to be restricted to
endothelial cells that form vessels, the
progenitors for
endothelial cells and the
progenitors blood cells.
Moreover, a substantial increase
in circulating
endothelial progenitor cells, which repair damaged blood vessels, was noted after consuming bread made from the ancient grain Verna.
A team from Cold Spring Harbor Laboratory
in Long Island, N.Y., reports that it staved off full - blown metastasis
in mice by preventing mini-tumors
in the lungs from recruiting stem cells called
endothelial progenitors, which assemble into blood vessels to nourish the malignancy.
Researchers from Massachusetts Eye and Ear have, for the first time, identified rapidly proliferating cells (known as «neural crest - derived
progenitor cells»)
in the corneal endothelium of specimens from normal corneas and from corneas with Fuchs»
Endothelial Corneal Dystrophy (FECD), a condition
in which the cells responsible for keeping the cornea clear die prematurely — often leading to blindness.
These cells were then grown
in the laboratory under special conditions to select for stem - like cells called
endothelial progenitor cells.
Endothelial progenitor cells (EPCs) differentiate into the cells that make up the lining of blood vessels, and so play roles
in vasculogenesis and angiogenesis.
Review of «Antitumor Effects of CD40 Ligand - Expressing
Endothelial Progenitor Cells Derived From Human Induced Pluripotent Stem Cells
in a Metastatic Breast Cancer Model» from Stem Cells TM by Stuart P. Atkinson.
Researchers from the laboratories of Hiroshi Y. Yoshikawa and Hideki Taniguchi had previously demonstrated the
in vitro formation of a 3D transplantable liver «organ bud» from human induced pluripotent stem cells (iPSCs) co-cultured with mesenchymal and
endothelial progenitors, and allows for the growth of a small vascularized and functional organ [1 - 3].
In this study, Chazaud et al., evidenced that
endothelial cells (ECs) and myogenic
progenitor cells (MPCs) interacted to couple myogenesis and angiogenesis during skeletal muscle regeneration.
Cardiovascular disease and renal disease for example are accelerated
in patients with diabetes and AGEs have been shown to induce senescence
in cell types related to these diseases, such as
endothelial progenitor cells, vascular
endothelial cells and renal cells.
Vascular
endothelial growth factor (VEGF) expressed by neural
progenitor cells (NPCs)(cyan) stimulates the growth of blood vessels (red)
in the mouse embryonic hindbrain, and provides regulatory factors to promote the self - renewal of neural
progenitors.
Our data confirms that
endothelial progenitors obtained from adult human blood vessels can be expanded
in vitro under xenoprotein - free conditions, for potential use
in endothelialization of small diameter ePTFE grafts.
DIC images of
endothelial progenitor cells (EPCs) during
in vitro expansion (A) and differentiation (B).
In those studies, sorted
progenitor cells, some of which could become
endothelial cells, were introduced into the heart.
To confirm if EPCs grown
in culture were
progenitor cells, clonogenicity of CD133 +
endothelial progenitors was tested.
The low density culture protocol helps
in generating larger number of CD133 +
endothelial population from initially fewer CD133 +
endothelial progenitor cells; EPCs (Figure S1).
Are new blood vessels being formed from existing capillaries or from novel
endothelial progenitors present
in the vasculature of young mice?