Sentences with phrase «in epidermal cells»

Similarly, lipid containing structures in epidermal cells (K and L) are bigger in wild type animals as shown in the (K) and smaller in mutant animals (L).

(A) The onset of expression of W01A8.1 a / c:: GFP in epidermal cells and in intestinal cells of three-fold embryo.

(E) and (G) W01A8.1 a / c:: GFP expression in epidermal cells and intestinal cells of a young adult hermaphrodite.

In contrast to embryos, lipid - containing structures in enterocytes and in epidermal cells of adult animals are smaller in mutants than in wild type animals.

Instead of aluminum starch or other anti-caking, mattifying components, we use bamboo silica: the protective layer in the epidermal cell walls of bamboo.

Not exact matches

«The cells we found perform immune surveillance and contain the virus in the key battlefield where infection occurs, which is the dermal - epidermal junction,» said Zhu.

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

The key to the buttercup's glow seems to lie in the exceptionally flat cells of its epidermal layer.

This keeps a portion of the incoming light from reaching the starch layer, ensuring that it is reflected in a directional manner by the flat cells at the base of the epidermal layer.

«CRKII most likely regulates the stability of mutated epidermal growth factor receptors and drives cancer growth by promoting signaling, or communication, within cancer cells,» said Julia Petschnigg, lead author on the paper and a postdoctoral fellow at U of T. «We found that a combinatorial chemotherapy that inhibits those mutated receptors and CRKII could be beneficial in treating lung cancer.»

Importantly, the new technique grows the pluripotent stem cells as floating spheres in high concentrations of two growth factors, fibroblast growth factor - 2 and epidermal growth factor.

A comparison of epidermal equivalents generated from iPSC, hESC and primary human keratinocytes (skin cells) from skin biopsies showed no significant difference in their structural or functional properties compared with the outermost layer of normal human skin.

Human epidermal equivalents representing different types of skin could also be grown, depending on the source of the stem cells used, and could thus be tailored to study a range of skin conditions and sensitivities in different populations.»

Multiplexed genetic screening for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker - guided treatment is cost - effective compared with standard chemotherapy treatment without any molecular testing in the metastatic non-small cell lung cancer (NSCLC) setting in the United States.

Among patients with advanced non-small cell lung cancer without a mutation of a certain gene (EGFR), conventional chemotherapy, compared with treatment using epidermal growth factor receptor tyrosine kinase inhibitors, was associated with improvement in survival without progression of the cancer, but not with overall survival, according to a study in the April 9 issue of JAMA.

Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA) from the plasma of advanced non-small cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient - matched tumor tissue DNA.

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the preferred treatment option for patients with advanced non-small cell lung cancer (NSCLC) who have mutations in the EGFR gene.

Earlier work hinted that skin follicles harbor stem cells kept in reserve to replace epidermal cells when they die.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

«It makes considerable headway in resolving a brewing controversy in the epidermal stem cell field» over exactly how the skin regenerates, she says.

«If you have a gene correction strategy,» he says, «you'd better have these primitive epidermal stem cells in mind.»

The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.

Wei Long Ng explained: «The two - step bioprinting strategy involves the fabrication of hierarchical porous collagen - based structures (that closely resembles the skin's dermal region), and deposition of epidermal cells such as keratinocytes and melanocytes at pre-defined positions on top of the biomimetic dermal skin constructs, to create 3D in - vitro pigmented human skin constructs.

Concurrently, this dermal cell aggregation triggers the mechanosensitive activation of β - catenin in adjacent epidermal cells, initiating the follicle gene expression program.

Epidermal growth factor receptor (EGFR) signal transduction plays a major role in growth, proliferation and differentiation of mammalian cells.

Josef Singer and Judith Fazekas, both lead authors of the study, discovered that a receptor frequently found on human tumor cells (epidermal growth factor receptor or EGFR) is nearly 100 percent identical with the EGF receptor in dogs.

Two studies are providing new insight into germline epidermal growth factor receptor (EGFR) T790M mutation in familial non-small cell lung cancer (NSCLC).

One of the key metabolic alterations that takes place during EMT is that of the epidermal growth factor receptor (EGFR) which is a pathway that regulates growth, survival, proliferation, and differentiation in mammalian cells.

Now, a team from Keio University in Japan, working with a researcher at Imperial College London, have discovered that the shape of the epidermal cells combined with their ability to temporarily glue together, may explain how they form this strong barrier.

The researchers, including scientists from pharmaceutical company AstraZeneca, report in an advanced online publication in Nature Medicine on May 4, that their findings indicate «an underappreciated genomic heterogeneity» in mechanisms of resistance to tyrosine kinase inhibitor (TKI) drugs that target the Epidermal Growth Factor Receptor (EGFR) mutation that drive some cases of non-small cell lung cancer (NSCLC).

In other cases, fails in the interlocking barrier between cells — the tight junctions — may partly explain why in psoriasis there is an overproduction of epidermal cells, causing thick patches of skin on the surfacIn other cases, fails in the interlocking barrier between cells — the tight junctions — may partly explain why in psoriasis there is an overproduction of epidermal cells, causing thick patches of skin on the surfacin the interlocking barrier between cells — the tight junctions — may partly explain why in psoriasis there is an overproduction of epidermal cells, causing thick patches of skin on the surfacin psoriasis there is an overproduction of epidermal cells, causing thick patches of skin on the surface.

The team in today's study say the epidermal cells» unique tetrakaidecahedron - like geometry means that it can always form a very tight, cohesive bond with the epidermal cells surrounding it.

Changes in cell junctions induced by inhibition of epidermal growth factor receptor in oral squamous cell carcinoma cells.

Human epidermis has been produced in vitro for decades using adult epidermal stem cells from donors to provide cell therapy.

Cell division was also stimulated with epidermal growth factor (EGF) at 10 ng / ml in a total added volume of 20 ml.

The translational fusion constructs resulted in high levels of cytoplasmic proteins present in intestinal and epidermal cells on vesicular structures with the characteristic appearance of lipid droplets.

In addition to causing proteins to be secreted through general pathways from the cell and pathways involving metalloproteases, PMA specifically causes activation of an epidermal growth factor receptor (EGFR).

In contrast to embryos, lipid - containing structures in intestinal and epidermal cells of adult W01A8.1 null mutants (Figs. 5J and 5L) were smaller than lipid - containing structures in control animals (Figs. 5I and 5KIn contrast to embryos, lipid - containing structures in intestinal and epidermal cells of adult W01A8.1 null mutants (Figs. 5J and 5L) were smaller than lipid - containing structures in control animals (Figs. 5I and 5Kin intestinal and epidermal cells of adult W01A8.1 null mutants (Figs. 5J and 5L) were smaller than lipid - containing structures in control animals (Figs. 5I and 5Kin control animals (Figs. 5I and 5K).

The epidermal growth factor receptor responsive miR - 125a represses mesenchymal morphology in ovarian cancer cells.

Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells.

Ng explains, «The two - step bioprinting strategy involves the fabrication of hierarchical porous collagen - based structures (that closely resembles the skin's dermal region), and deposition of epidermal cells such as keratinocytes and melanocytes at pre-defined positions on top of the biomimetic dermal skin constructs, to create 3D in - vitro pigmented human skin constructs.

In most adult tissues, cells go about their daily business — absent a command from a growth factor, such as epidermal growth factor (EGF), they don't really need to grow, much less divide.

DENVER — Leptomeningeal metastases (LM), a devastating complication and predictor of poor survival in lung cancer patients, was found to be more prevalent in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations.

Title: Capturing epidermal stemness for regenerative medicine Authors: Barrandon Y, Grasset N, Zaffalon A, Claudinot S, Lathion Droz - Georget S, Nanba D, Rochat A Date: 2012 Publication Details: Seminars in Cell & Developmental Biology 2012 Oct 2.

Transient assays were done in onion epidermal cells using the plant signal sequence fused to RBP and a GFP reporter (ssRBP - GFP fusion protein) with RBP fused to GFP as a control.

Equally impressive is the ability of a caudal fin to regenerate bone, nerves, blood vessels, epidermal, and pigment cells in about 7 - 10 days following complete amputation.

To confirm, evaluate, and quantify the extent of such exponential behavior in individual plant roots, we analyzed root epidermal (trichoblast, to be able to recognize root hair) and cortex cell files of wild ‐ type Col ‐ 0 ecotype, from day 1 to 10 postgermination (Materials and Methods, Dataset EV1).

Along the same lines, in non-small cell lung cancer (NSCLC), acquired resistance to Gefitinib / Erlotinib kinase inhibitors has also been associated with a secondary mutation of the gatekeeper Thr790 residue of the epidermal growth factor receptor (EGFR).

Current studies focus mainly on two receptor systems - the mast cell surface receptor, FcεRI, and the receptor for epidermal growth factor that operate in immunological and cell proliferation responses.

Epidermal and cortical cells were measured individually in each plant along a single file and each analyzed time point using ImageJ software (http://rsb.info.nih.gov/ij/).