Sentences with phrase «in epigenetic control»

Researchers have identified a host of factors involved in epigenetic control of gene expression and development, but many of the precise mechanisms underlying this type of regulation remain unclear.

«Instead, those people might have mutations in epigenetic controls called «enhancers.»

Not exact matches

In a matched case - control design, they found a potential genetic - epigenetic biomarker of postpartum depression.

We can not use randomized controlled experiments with people but do so with animals, demonstrating, for example in Michael Meaney's lab, that affectionate touch in early life is critical for epigenetic controls of anxiety in mammals.

Each cell carries this information tightly packed on a two - meter long DNA strand in the cell nucleus and specific epigenetic mechanisms control access to the «blueprint of life».

The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches.

The genome - wide epigenetic changes clustered in certain chromatin domains and controlled «gene expression changes that specify different malignant traits, including the ability to form tumors,» McDonald said.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

In light of this shortcoming, some investigators see room for an increased focus on an alternative explanation for heritable traits: epigenetics, the molecular processes that control a gene's potential to act.

Gene Robinson, a geneticist at the University of Illinois at Urbana - Champaign, says that the paper «opens a new line of study on the role of epigenetics in controlling reproductive conflict» in bumblebees.

Clinicians could then prevent the disease by placing teenagers predisposed to this epigenetic change on a birth control pill regimen, preventing the possibility of retrograde menstruation in the first place, Bulun said.

DNA methylation, one mechanism of epigenetics, is a chemical tag on DNA that does not change the gene sequence but is involved in controlling gene expression.

«Potentially reversible changes in gene control «prime» pancreatic cancer cells to spread: Epigenetic changes, not DNA mutations, drive some metastasis.»

The fact that a thousand proteins are involved in epigenetic regulation is pretty astounding, because that's just a genes wrapped up in controlling genes.

The drug, lapatinib, activates the suppressor called FOXO, in HER2 + breast cancer cells, but then FOXO becomes a turncoat molecule, working with an epigenetic regulator that controls gene expression.

The readability of genes is controlled by epigenetic factors, namely factors which do not influence the gene sequence directly, but rather cause certain genes and chromosomal segments to be packed in different densities — and thus make them accessible for reading.

The specific pattern of epigenetic marks in a cell type specifies identity and this epigenetic control is vital to what makes our cells different, for example a skin cell from a liver cell, when they all contain the same genetic instructions.

The researchers used tools of epigenomic analysis to trace the specific epigenetic switches controlling each of thousands of genes in both mouse and human retinal cells as the cells progressed through development.

Joining forces with dermatologists and oncologists from the University Hospital in Zurich and backed by the University Research Priority Program «Translational Cancer Research,» Sommer's team was able to demonstrate that, in melanoma cells, the epigenetic factor EZH2 controls genes that govern tumor growth as well as genes that are important for the formation of metastases.

In addition, they demonstrate that the repression mechanism of Chrono is under epigenetic control and links, via a glucocorticoid receptor, to metabolic pathways triggered by behavioral stress.

In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control geneIn animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genein metabolic control genes.

The research team behind the study, which is being published in the journal Epigenetics, also found strong links between these altered epigenetic patterns and the activity in genes controlling improved metabolism and inflammation.

Step one of the environmental epigenetic control pathway is that the cell initiates a specific change to one amino acid in a protein named JMJD1A and this altered JMJD1A recruits other proteins.

«Mom's in control, even before you're born: Egg's epigenetic «blueprint» important for placenta development in pregnancy.»

A major aspect of our work centers around transcriptional and epigenetic control of plasticity in cardiomyocytes, smooth muscle, and skeletal muscle in physiology and disease.

The current work shows that changes in the genetic code of a particular gene can control epigenetic marks at different genes, implying that a gene's genetic code can affect whether other genes are turned on and off, which makes it important to understand the function of all genes involved, not just the one with the so - called misspelling.

We attempt to understand how the organisation of chromatin determines the epigenetic control of T cell responses in vitro and in vivo.

However, 15,627 CpG sites in / near ∼ 30 % of all genes exhibited differential methylation in adipose tissue from a case - control cohort of unrelated individuals, supporting a key role for epigenetic modifications in T2D patients.

Hypothetical roles of the methyltransferase could involve any of the following: 1) the epigenetic control of differential pir gene expression in acute and chronic infections50, 2) the sequence may have a role in genome stability and recombination, or 3) this could be a selfish gene that was able to transpose.

This is number two in my series of blogs on epigenetic control of genome restructuring and hereditary transmission of traits...

Dr. Loftus» current research integrates the identification of these types of epigenetic modifications that mark the melanocyte regulatory genomic landscape with regulatory protein and transcription factor chromatin - binding domains, thus defining groups of non-coding DNA sequences utilized in the control of melanocyte gene expression.

New research led by the University of Bristol has found that genes in the brain that play a crucial role in behavioural adaptation to stressful challenges are controlled by epigenetic mechanisms.

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If we continue to advance in the study of endocannabinoids, another report entitled «Epigenetic control of skin differentiation genes with phytocannabinoids» confirms that the endocannabinoid system plays a role in epidermal physiology.

I use epigenetic approach to identify the sexually dimorphic genes that control sexual differentiation in the mouse brain structure and behavior.

In it she talks about her longstanding interests in chromatin, transcriptional control and epigeneticIn it she talks about her longstanding interests in chromatin, transcriptional control and epigeneticin chromatin, transcriptional control and epigenetics.

In this work, we have analyzed at blastocyst stage the expression of some genes that are modifiers of epigenetic gene silencing that produce considerable variance in many complex traits in inbred individuals reared in controlled environments [39, 40In this work, we have analyzed at blastocyst stage the expression of some genes that are modifiers of epigenetic gene silencing that produce considerable variance in many complex traits in inbred individuals reared in controlled environments [39, 40in many complex traits in inbred individuals reared in controlled environments [39, 40in inbred individuals reared in controlled environments [39, 40in controlled environments [39, 40].

Next up was Didier Trono who talked about how transposable elements and their epigenetic control mechanisms are key regulators of transcriptional networks in PSCs.

While we don't have that many genes, scientists have very recently discovered ways to control the modest number we have, in an exciting new field called epigenetics.

The group's study titled «Glucose Restriction Can Extend Normal Cell Lifespan and Impair Precancerous Cell Growth Through Epigenetic Control of hTERT and p16 Expression» has been published in the online edition of The Journal of the Federation of American Societies for Experimental Biology, or FASEB Journal.

Stress paradigms in rodent models have been associated with elevated anxiety and contrasting alterations in neuronal morphology in the hippocampus and amygdala, with dendritic atrophy observed in the hippocampus and increased dendritic arborization in the amygdala.12, 13 Developing rodents deprived of maternal nurturance show decreased hippocampal volume and altered stress reactivity.14 An epigenetic mechanism for this effect has been elaborated.15 Importantly, controlled trials that have randomized institutionalized toddlers to early therapeutic foster care vs institutionalization have documented the deleterious effects of early relative deprivation on cognitive outcomes.16