Sentences with phrase «in epigenetic studies»
This study has provided a framework for DNA methylation from saliva and has shown the way for the use of saliva DNA in epigenetic studies of psychiatric disorders.
http://www.frontlinegenomics.com/ Not exact matches
Because epigenetics is the real driver of your health status, and diet plays a major role in gene expression (aka epigenetics), at least in this post's animal study!
De novo mutations and epigenetic changes could both be contributing factors in another recent study linking a father's age to stillbirth, pre-term birth and low birth weight.
A new study in Biological Psychiatry found that heroin use is associated with excessive histone acetylation, an epigenetic process that regulates gene expression.
Professor Keith Godfrey, from the Medical Research Council Lifecourse Epidemiology Unit and the National Institute for Health Research Southampton Biomedical Research Centre, and a member of the study team, said: «The new findings provide the first direct evidence linking faltering of a baby's growth in the womb with epigenetic modifications that themselves may increase the risk of childhood obesity.
«Our study shows that epigenetic drift, which is characterized by gains and losses in DNA methylation in the genome over time, occurs more rapidly in mice than in monkeys and more rapidly in monkeys than in humans,» explains Jean - Pierre Issa, MD, Director of the Fels Institute for Cancer Research at LKSOM, and senior investigator on the new study.
DNA methylation, or the addition of methyl tags to DNA, is one of the most well - studied epigenetic signals; errors in this process are commonly found in cancer.
In this genome - wide association study, researchers found gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleratioIn this genome - wide association study, researchers found gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleratioin three loci associated with extrinsic epigenetic age acceleration.
«Epigenetics of addiction: Epigenetic study untangles addiction and relapse in the brain.»
Yan noted that human genetics studies have suggested that epigenetic abnormalities likely play a major role in ASD.
«Genome wide association study of epigenetic aging rates in blood reveals a critical role for TERT.»
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The study, published in Nature Structural and Molecular Biology, showed that a combination of genetics and epigenetics — factors that turn genes on or off — could explain how lactose intolerance develops over time.
Earlier this year, Feinberg led a study that considered this view of epigenetics in metastatic pancreatic cancer cells.
A major finding of this study is that the genetic loci associated with asthma are enriched in epigenetic marks characterizing gene enhancers.
The study results build on genetic and epigenetic basics, including that the blueprint for the human body is encoded in genes that direct the building of one or more proteins.
However, in some studies with laboratory mice, Feinberg had observed that these epigenetic tags varied considerably among the mice even when comparing the same type of tissue in animals that have been living in the exact same conditions.
«There's a complex interplay between hormones, experience and epigenetic changes in response to life events,» says neuroscientist Cheryl Sisk, who studies sex differences in the brain at Michigan State University in East Lansing.
Study results suggest that pharmacological action on these epigenetic alterations may be helpful in slowing disease progression.
A study published this week in PLOS Medicine suggests that epigenetic modification of the HAND2 gene plays a critical role in the development of endometrial cancer.
A case study in the epigenetic effects of upbringing in humans can be seen in the life of Szyf's and Meaney's onetime collaborator, Frances Champagne.
In a new study published in the Journal of Allergy and Clinical Immunology, researchers have now found a new principle for how epigenetic changes can occuIn a new study published in the Journal of Allergy and Clinical Immunology, researchers have now found a new principle for how epigenetic changes can occuin the Journal of Allergy and Clinical Immunology, researchers have now found a new principle for how epigenetic changes can occur.
«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.
Studies in cancer patients indicate reduced rates of relapse when patients are pretreated with epigenetic drugs due to its far - reaching capabilities; killing progenitor cells at the site of the tumor, in circulation, or at a distant site.
In a new study, researchers at Uppsala University have found evidence of a new principle for how epigenetic changes can occur.
«It is expected that this study will lay the foundation for developing a new class of potent and effective cancer therapies and the development of reagents targeting epigenetic events in immune - mediated diseases as well as other epigenetically - influenced diseases,» said Alani, who also is chief of dermatology at Boston Medical Center.
In a new study published in the journal Nature Structural and Molecular Biology researchers at Karolinska Institutet in Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomeIn a new study published in the journal Nature Structural and Molecular Biology researchers at Karolinska Institutet in Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomein the journal Nature Structural and Molecular Biology researchers at Karolinska Institutet in Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomein Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomein the correct segregation of chromosomes.
In studies that document parent - to - child epigenetic inheritance, it's not clear what's being passed on, and understanding it molecularly is very complicated.
All animals use the same enzyme to create the same methylation mark as a signal for gene repression, and her colleagues who study epigenetics in mice and humans are excited about the new findings, Strome said.
New findings published in the Proceedings of the National Academy of Sciences showed in lab studies that supplementing an epigenetic cancer drug called decitabine with vitamin C enhanced the drug's ability to impede cancer cell growth and trigger cellular self - destruction in cancer cell lines.
Another study by a different group in the same journal in October 2009 looked at ART effects on epigenetics (non-DNA changes in genes) in humans.
Gene Robinson, a geneticist at the University of Illinois at Urbana - Champaign, says that the paper «opens a new line of study on the role of epigenetics in controlling reproductive conflict» in bumblebees.
«This means that the epigenetic modifications are likely not caused by substances in the tobacco, but by the hundreds of different elements that are formed when the tobacco is burnt,» says Åsa Johansson, researcher at the Department of Immunology, Genetics and Pathology at Uppsala University and Uppsala Clinical Research Center, who has led the study.
Yi Zhang, who studies epigenetics at Harvard Medical School in Boston, Massachusetts, and who has been using Saitou's method, has also found that in vitro PGCs do not erase their previous epigenetic programming as well as naturally occurring PGCs.
Such epigenetic mechanisms are high on the list of suspects when it comes to explaining how environmental factors that affect parents can later influence their children, such as in the Dutch second world war study, but just how these epigenetic changes might be passed on to future generations is a mystery.
And because epigenetic changes typically occur early in life, it may one day be possible to identify young people at risk for suicide by studying their methylation patterns and then to treat them with drugs that regulate this mechanism, Szyf notes.
In addition to RNA transcripts linked with inflammation and stress, the study examines a series of epigenetic transcripts — RNA sequences that have undergone post-transcriptional modification.
They also collected DNA to study epigenetics — changes in the activity of how a gene is expressed through environmental experiences, rather than alteration of the genetic code itself.
Early results from a larger, ongoing study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst suggest that phthalate levels in expectant fathers have an effect on couples» reproductive success via epigenetic modifications of sperm DNA.
The new study is among the first to investigate the influence of phthalate on sperm epigenetics in humans.
Jean - Pierre Issa, MD, Director of the Fels Institute for Cancer Research and Molecular Biology at Temple University School of Medicine and co-Leader of the Cancer Epigenetics Program at the Fox Chase Cancer Center is lead author of the study, which has been published August 19 in the journal, Lancet Oncology.
The researchers performed a «genome - wide» study in children with newly diagnosed CD, before any treatment, to look for possible epigenetic changes that may affect gene behavior.
His group specialises in the study of the genetic and epigenetic regulation of female germ cell development.
A new study finds a wide range of epigenetic changes — alterations in DNA across the genome that may be related to key environmental exposures — in children with Crohn's disease (CD), reports Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America (CCFA).
The authors believe theirs is among the first human studies to investigate the influence of phthalate exposure on sperm epigenetics, embryo development and whether DNA methylation in sperm cells may be a path by which a father's environmental exposure influences these endpoints.
«Epigenetic changes in children with Crohn's disease seen in study.»
In a study appearing February 18 in Cell Metabolism, researchers link this difference to an epigenetic change in the stressed dad's sperm — a change that they could prevent by blocking the father's stress hormoneIn a study appearing February 18 in Cell Metabolism, researchers link this difference to an epigenetic change in the stressed dad's sperm — a change that they could prevent by blocking the father's stress hormonein Cell Metabolism, researchers link this difference to an epigenetic change in the stressed dad's sperm — a change that they could prevent by blocking the father's stress hormonein the stressed dad's sperm — a change that they could prevent by blocking the father's stress hormones.
«I think it's a fine paper [and a] well - designed study,» said Michael Skinner, who studies epigenetic inheritance at Washington State University and was not involved in the study.
The study of epigenetic changes in the body's hormone - based stress system has shown that stress - related changes in the CRH gene are linked to both serious suicide attempts in adults and psychiatric illness in adolescents.
This finding echoes the results of many other human epigenetic studies that show that the effects of certain experiences during childhood and adolescence are especially enduring in individuals and sometimes even across generations (right).