Sentences with phrase «in epithelial tissues»

In epithelial tissues this results -LSB-...]

NGAL (also known as Lipocalin - 2 or Neutrophil Gelatinase - associated Lipocalin) is a small, ~ 25kDa secreted protein expressed in epithelial tissues and released into both urine and blood upon kidney tubular damage.

August 2, 2006 Jeffrey Matthews appointed chairman of surgery at the University of Chicago Gastrointestinal surgeon Jeffrey Matthews, MD, a leading authority on the surgical treatment of diseases of the pancreas, bile ducts and liver, and a prominent scientist known for his fundamental research on defects in chloride transport in epithelial tissue, has been appointed chairman of surgery at the University of Chicago, effective October 1, 2006.

These growths originate in the epithelial tissue of a gland beneath a nipple and eventually spread (metastasize) to the lymph nodes, lungs, pleura, liver, adrenal gland, kidney, or other parts of the body.

Not exact matches

Geoff Oxnard, an assistant professor of medicine at Dana - Farber Cancer Institute and Harvard Medical School in Boston and one of Paweletz's collaborators, remarks that «I had a hospitalized patient last week, she's sick with metastatic lung cancer, and she's exactly the kind of patient who might have an [epithelial growth factor receptor (EGFR)-RSB- mutation, but I simply didn't have enough tissue to ask those questions yet.»

If they succeed, they can be reasonably confident that epithelial cells can be taken from a patient and used to regenerate damaged tissue in that same person.

Lecuit, who researches the organisation of epithelial tissues in developing organs, learned to resist these temptations at about the time he became an independent scientist.

What's more, the researchers discovered two years ago that the suppression of Esrp activity helps to enable a process called the epithelial - mesenchymal transition (EMT), in which epithelial cells acquire properties allowing them to detach and develop into new tissue.

Esrp1 and Esrp2 are active specifically in epithelial cells, which form the skin, the inner layers of the gut and lung, and other tissues in the body.

So Welham's team set out to engineer vocal fold mucosae in the lab using the two main cell types that make up the tissue — connective fibroblasts, which form the main body, and epithelial cells, which line the surface.

By manipulating it in vitro, a team of researchers led by Prof. David Mooney at Harvard SEAS have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

In this study, the researchers used progenitor cells that were poised to become epithelial tissue, a key component of the lacrimal gland.

These differently expressed microRNAs may contribute to stem cell and epithelial (tissue cells) abnormalities in diabetic corneas.

The study team assessed three sets of outcomes: a maturational index (MI) based on epithelial cells from the children's urogenital tissue; ultrasound measurements of uterine, ovarian and testicular volume, as well as breast - buds; and hormone concentrations seen in blood tests.

Previous work by Fredberg and colleagues had documented the importance of collective cellular behavior in asthma, showing that cells comprising epithelial tissues — which line the surfaces of all organs throughout the body — can unjam and flow like a fluid, or jam and freeze like a solid.

Matthews» laboratory research, with long - term support from the National Institutes of Health, focuses on the fundamental mechanisms used by epithelial tissues to regulate salt secretion — which goes awry in several diseases, including cystic fibrosis and many forms of diarrhea.

The inner wall of the small intestine is lined with epithelial tissue covered in wrinkles and folds from which villi — microscopic fingerlike pieces of tissue — project, increasing the surface area for absorption.

As anticipated from the identification of Lgr5 + as a marker of ASCs in multiple other tissues, a similar approach proved successful in generating organoids or tumoroids from virtually any epithelial organ or tissue (2,3).

In particular we are interested to unravel the mechanisms that ensure the maintenance of the apical membrane when exposed to physical stress, e. g. during morphogenesis of epithelial tissues, or when exposed to light stress in photoreceptor cells, using Drosophila and zebrafish as model organismIn particular we are interested to unravel the mechanisms that ensure the maintenance of the apical membrane when exposed to physical stress, e. g. during morphogenesis of epithelial tissues, or when exposed to light stress in photoreceptor cells, using Drosophila and zebrafish as model organismin photoreceptor cells, using Drosophila and zebrafish as model organisms.

Epithelial tissues undergo profound changes in shape during animal development.

Using cutting - edge techniques enabled by next - generation sequencing, the authors generated complete methylome maps at single nucleotide resolution in a low - passage breast cancer cell line and normal breast tissue (primary human mammary epithelial cells).

It has an essential role in salt and fluid homeostasis across epithelial tissues.

Mitchell D, Paniker L, Godar D (2012) Nucleotide excision repair is reduced in oral epithelial tissues compared with skin.

«Also in real life, organs have an epithelial lining, a vascular component, connective tissues and immune cells, none of which can yet be replicated in their normal physical arrangement in organoids,» says Donald Ingber, founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard University.

Researchers demonstrate that autologous oral mucosal epithelial cells expanded under good manufacturing practice requirements can reverse limbal stem cell deficiency in injured eyes up to 24 months, representing an advance in ocular tissue regeneration and transplantation

By using a combination of genetics, fix and live imaging, cell biology and molecular biology techniques we are exploring the consequences of polyploidy in the brain and epithelial tissues of Drosophila.

In this paper, we study the development and migration of epithelial tissues on glass wires of well - defined radii varying from less than 1 µm up to 85 µm.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

Interestingly, RIPK2 has been demonstrated to be involved in the active growth of CD90 (+) intestinal stromal cells to suggest an «inflammatory» cross-talk between intestinal stromal cells and the epithelial cells (Owens et al., 2013), and we can observe robust activation of RIPK2 in IBD colon tissue sections immunostained with our proprietary pY474 RIPK2 antibody (Salla et al., unpublished observations).

In human gastric tissue, however, gastric epithelial cell proliferation is significantly higher but apoptotic indices are lower among persons colonized with cag + compared to cag - strains or uninfected persons leading us to postulate that reduced rates of cell loss, when accompanied by hyperproliferation, may heighten retention of mutagenized cells, which could predispose towards cancer.

Weaver also said that the predictions made by jamming models resemble what biologists call extrusion, a process by which dead epithelial cells are squeezed out of crowded tissue — the disfunction of which has recently been implicated in certain types of cancer.

In a wide range of epithelial tissues such as kidney tubules or breast acini, cells organize into bidimensional monolayers experiencing an out - of - plane curvature.

Yohanns Bellaiche's teams, Polarity Division Morphogenesis --(CNRS / Inserm / Institut Curie), works on the organisation of tissue cells just published its latest results in the revue Nature: Epithelial tricellular junctions act as interphase...

Residing in the epithelial cells that line our skin and gut are specialised T cell compartments that run tight immune surveillance on local tissues.

(C) Degree of branching and number of mammary epithelial cell layers in the mammary tissue formed by mammary cells infected with miR - 150.

In normal mammary tissues, LARP7 was highly expressed in the epithelial cells of the mammary lobuli and terminal ducts (Figure 1CIn normal mammary tissues, LARP7 was highly expressed in the epithelial cells of the mammary lobuli and terminal ducts (Figure 1Cin the epithelial cells of the mammary lobuli and terminal ducts (Figure 1C).

Cambridge, Mass. — June 16, 2014 — A team of researchers led by David J. Mooney, Robert P. Pinkas Family Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences (SEAS), have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

While vitamin A is best known for its vital role in vision, the retinoid forms of this vitamin also participate in physiological activities related to the immune system, inflammatory system, maintenance of epithelial and mucosal tissues, growth, reproduction, bone development, creation of red blood cells, and production of spermatozoa (male reproductive cells).

That's like the epithelial tissue in our gut lining and if we just pull our tissue or pull our hands apart just enough to create a little bit of daylight, that starts to hap — that's what's happening when we start to have a leaky gut, and again the leaky gut could be one, from eating bad foods, right?

The body's own immune system attacks the cells that line the small intestine, resulting in the characteristic shortening or pruning of the intestinal villi (microscopic, finger - like projections of small intestine wall tissue made of columns of gut epithelial cells).

Some say there is no link and that the increased rate of cancer in this quadrant is because it contains the most epithelial tissue.

Alpha Herpesviruses such as FHV - 1 cause disease by two distinctly different mechanisms: 1) cytolytic (cell - rupturing) disease which involves active viral replication and destroys the epithelial cells of the cornea and conjunctiva causing ulceration; and, 2) immune - mediated disease results from the deposition of viral antigen in subepithelial tissues.

There are various types of bladder tumors like squamous cell carcinoma (arise in the epithelial cells), adenocarcinoma (arise in the glandular epithelium), undifferentiated carcinoma, rhabdomyosarcoma (tumor of the striated muscle - form of fibers combined into parallel fibers like the skeletal and the cardiac muscles), fibroma (tumors made of fibrous or connective tissue.

Histopathology (microscopic examination of tissues) is important, because in the urine of atleast 30 % of dogs, neoplastic cells can not be differentiated from reactive epithelial cells associated with inflammation.

In this context those antibiotics are usually preferred which are strong enough to reach in tracheo bronchial mucosa (surfaces covered with fluid & cells, usually «squamous epithelial tissues»In this context those antibiotics are usually preferred which are strong enough to reach in tracheo bronchial mucosa (surfaces covered with fluid & cells, usually «squamous epithelial tissues»in tracheo bronchial mucosa (surfaces covered with fluid & cells, usually «squamous epithelial tissues»).

They arise from different types of tissues (epithelial or glandular tissues, and mesenchymal or connective tissues) in the mammary gland.

Cancers can be divided into three general groups: carcinomas that arise from epithelial cells that cover the body (skin) or line internal body surfaces; sarcomas that begin in connective, skeletal, muscular, or reproductive tissues; lymphomas that invade the lymph nodes and the lymphatic system.

One of the greatest benefits of zinc is in the maintenance and production of epithelial tissue.

Mammary gland tumors can be either malignant (cancerous) or benign (non-cancerous) and arise from the different types of tissues (epithelial or glandular tissues, and mesenchymal or connective tissues) in the mammary gland.