Part of the cytoskeleton, vimentin gives flexibility and structure to the cell, but it is also a marker of epithelial - mesenchymal transition (EMT), which is considered a crucial event for metastasis
in epithelial tumors.
Not exact matches
Critics of the inclusion of isoflavones
in food claim that they increase the incidence of
epithelial hyperplasia, which precedes cancerous
tumors, and that they cause goitre and hyperthyroidism.
This study aimed to determine whether
epithelial - derived MMP9 has a defensive role of
tumor suppressor
in CAC and the underlying molecular mechanism.
«Our system is based around a molecule called E-cadherin, which suppresses
tumor growth
in part by maintaining cells
in an
epithelial rather than a mesenchymal state,» Tomoki Muramatsu of TMDU says.
In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damag
In addition, they found that
epithelial - derived MMP9 suppresses
tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damag
in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.
«These results showed us that
epithelial TRPV1 normally works as a
tumor suppressor
in the intestines,» said de Jong.
The cell changes, known as an
epithelial to mesenchymal transition, or EMT, are normal and helpful during wound healing, but problematic when cancer cells spread from the primary
tumor site to other sites
in the body.
Unrestrained
epithelial cell extrusion has been linked to
tumor cell invasion and metastasis
in other studies.
This study demonstrated that emulsifier - induced alterations
in the microbiome were necessary and sufficient to drive alterations
in intestinal
epithelial cells» homeostasis, which is thought to govern
tumor development.
The effects of consuming emulsifiers were eliminated
in mice devoid of microbiota (germ - free mice), and transplanting microbiota from emulsifier - treated mice to germ - free mice was sufficient to transfer alterations
in intestinal
epithelial cells» homeostasis, suggesting a central role played by the microbiota
in tumor development.
The absence of
tumors in virgin Nrk mutant mice strongly suggests that the tumorigenesis is closely related to the proliferation of mammary
epithelial cells during pregnancy.
In Nrk mutant mammary glands, dense clusters of ER alpha - positive mammary
epithelial cells were sometimes observed at late stages of pregnancy, which may represent the «bud» of the breast
tumor.
Additionally, overexpression of POSTN
in human mammary
epithelial and breast cancer cells resulted
in enhanced
tumor growth and metastasis (Wang et al., 2013), which is similar to a colon cancer cell model where overexpression of POSTN resulted
in an increase
in the number and size of liver metastases (Bao et al., 2004).
In many epithelial malignancies alpha2 beta1 integrin expression is diminished or lost in a manner that correlates with the loss of epithelial differentiation and tumor progressio
In many
epithelial malignancies alpha2 beta1 integrin expression is diminished or lost
in a manner that correlates with the loss of epithelial differentiation and tumor progressio
in a manner that correlates with the loss of
epithelial differentiation and
tumor progression.
We use multiple mouse models combined with
in vitro approaches to address the pleiotropic functions of these cytokines which affect both the
epithelial cancer cells and the inflammatory infiltrate within
tumors.
Moreover, following transformation with H - Ras, these cells initiated
tumor xenografts
in immunocompromised mice with higher efficiency than their
epithelial counterparts [5].
The Joslin team found that intestinal
tumors grow just as quickly
in a mouse cancer model whose «
epithelial» cells lining the inside of the intestine have been genetically modified so that insulin can't activate the cells.
In a first set of experiments, postdoctoral researcher and co-lead author Max - Felix Häring found that insulin increased the proliferation of mouse epithelial tumor cells in culture, as expecte
In a first set of experiments, postdoctoral researcher and co-lead author Max - Felix Häring found that insulin increased the proliferation of mouse
epithelial tumor cells
in culture, as expecte
in culture, as expected.
They showed that miR - 200 was always present
in epithelial (less invasive) and not
in mesenchymal (more invasive) types of
tumors.
What: The Second Edition of the IASLC Staging Manual
in Thoracic Oncology reports on the latest revisions of the
tumor, node and metastasis (TNM) classifications of thoracic malignancies, namely, lung cancer, malignant pleural mesothelioma, carcinoma of the esophagus and of the esophago - gastric junction and thymic
epithelial tumors.
In conclusion, p21 deficiency results in the spontaneous development of a variety of tumors of hematopoietic, endothelial, and epithelial origi
In conclusion, p21 deficiency results
in the spontaneous development of a variety of tumors of hematopoietic, endothelial, and epithelial origi
in the spontaneous development of a variety of
tumors of hematopoietic, endothelial, and
epithelial origin.
Combined niclosamide with cisplatin inhibits
epithelial - mesenchymal transition and
tumor growth
in cisplatin - resistant triple - negative breast cancer.
In combination with cisplatin, niclosamide inhibited epithelial - mesenchymal transition (EMT) and tumor growth in triple - negative breast cancer [34
In combination with cisplatin, niclosamide inhibited
epithelial - mesenchymal transition (EMT) and
tumor growth
in triple - negative breast cancer [34
in triple - negative breast cancer [34].
Tumor necrosis factor alpha and inflammation disrupt the polarity complex
in intestinal
epithelial cells by a posttranslational mechanism.
Oct4 Mediates
Tumor Initiating Properties
in Oral Squamous Cell Carcinomas through the Regulation of
Epithelial - Mesenchymal Transition.
In the classical model of
tumor dissemination, specialized cells at the invasive front undergo
epithelial - mesenchymal transition (EMT) and enter peripheral
tumor - coalescing blood vessels to establish metastatic lesions by extravasation of CTCs.
The
epithelial - to - mesenchymal transition (EMT) and the reverse process (the mesenchymal - to -
epithelial transition [MET]-RRB- have been shown to be associated with
tumor cell invasion and metastasis
in different carcinomas.
Oncologists have suspected for several decades that metastasis usually requires a transition between sticky
epithelial cells, which make up the bulk of solid
tumors, and thinner, more mobile mesenchymal cells that are often found circulating solo
in cancer patients» bloodstreams.
Moreover, ablation of a STAT5A allele reduces
tumor incidence
in a mouse model of breast cancer
in which mammary
epithelial cells express T antigen (48).
Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors)
in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals,
epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells
in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived
tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation
in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels
TGFβ inhibits
tumor initiation and progression by inducing cell cycle arrest and apoptosis; however
epithelial tumorigenesis may escape this common antitumor mechanism by inducing aberrations
in TGFβ signaling resulting
in enhanced development and progression of human carcinomas.
A class of drugs called EZH2 inhibitors are currently
in clinical development for both hematological malignancies and solid
tumors and may be effectively targeted to
epithelial ovarian cancers overexpressing the CARM1 protein.
Interestingly, long - term — cultured human
epithelial cancer cells
in clonal cultures also form holoclones, meroclones, and paraclones, and
tumor cell holoclones have been hypothesized to harbor stem - like cells or cancer stem cells.
Carcinomas arise from
epithelial cells, and
tumor progression involves a loss of polarity, so an understanding of cell polarity is important
in the identification of novel therapeutic approaches to cancer.
Last year, Mandriota and collaborators demonstrated that
in a cancer mouse model, concentrations of aluminum
in the amount of those measured
in the human breast are able to transform cultured mammary
epithelial cells, allowing them to form
tumors and to metastasize.
More specifically, he researches the use of anti-CEA antibodies for
tumor imaging and therapy, as well as the role of CEACAM1
in T - cell activation and mammary
epithelial cell polarization.
Considering that miR - 142 is highly expressed
in human BCSCs, but weakly expressed or undetectable
in the stem / progenitor population of the mammary
epithelial cells, our result suggest that the upregulation of miR - 142 and its enhancement of the miR - 150 expression seem to be especially relevant
in the breast
tumor progression
in vivo.
Abnormal growths
in the lower intestines of dogs include benign polyps and adenomas as well as cancerous
epithelial tumors, or adenocarcinomas.
Stromal granulosa cell,
epithelial tumors and dysgerminomas may become very large,
in which case a swollen abdomen is the main sign.
However, this is not absolute and an ovarian
epithelial tumor has been recorded
in association with pyometra (pus
in the uterus) at one year of age.
Granulosa cell and
epithelial tumors are the most common ovarian
tumors in bitches.
There are various types of bladder
tumors like squamous cell carcinoma (arise
in the
epithelial cells), adenocarcinoma (arise
in the glandular epithelium), undifferentiated carcinoma, rhabdomyosarcoma (
tumor of the striated muscle - form of fibers combined into parallel fibers like the skeletal and the cardiac muscles), fibroma (
tumors made of fibrous or connective tissue.
Mammary gland
tumors can be either malignant (cancerous) or benign (non-cancerous) and arise from the different types of tissues (
epithelial or glandular tissues, and mesenchymal or connective tissues)
in the mammary gland.