Sentences with phrase «in erythroid»

Therapeutic levels of fetal hemoglobin in erythroid progeny of -LCB- beta -RCB-- thalassemic CD34 + cells following lentiviral vector - mediated gene transfer.

Porphyrin formation entails PBG deaminase - dependent HMB synthesis; limiting (or absent) expression of downstream enzymes in the heme biosynthesis pathway (grey) leads to non-enzymatic cyclization of HMB to form uroporphyrinogen I, as in the erythroid cells of CEP patients (Discussion).

Not exact matches

The proteins in them are characteristic of fetal and embryonic cells rather than of mature erythrocytes, and the authors take care to call them «erythroid cells» rather than true erythrocytes.

Sustained activation of nuclear erythroid 2 - related factor 2 / antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.

Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low - risk myelodysplastic syndromes.

Targeted disruption of nuclear factor erythroid - derived 2 - like 1 in osteoblasts reduces bone size and bone formation in mice.

Surprisingly, and in stark contradiction of the established dogma, we discover that the first events in myeloid and erythrocyte lineage commitment involve massive expansion of the repertoire of enhancers (approximately 6,382, 5,834 and 4,859 de novo enhancers in the myeloid, lymphoid and erythroid respectively).

Its presence in all erythropoietin - independent erythroid colonies demonstrates a link with growth factor hypersensitivity, a key biological feature of these disorders.

The mutation was present in all erythropoietin - independent erythroid colonies.

It was heterozygous in most patients, homozygous in a subset as a result of mitotic recombination, and arose in a multipotent progenitor capable of giving rise to erythroid and myeloid cells.

A recent review from Juliana Xavier ‐ Ferrucio and Diane S. Krause (Yale University, New Haven, CT, USA) focuses on recent advances in the identification and characterization of bipotent megakaryocytic ‐ erythroid progenitors (MEPs).

«Long non-coding RNA mediated anti-apoptotic activity in murine erythroid terminal differentiation»