Sentences with phrase «in every different cell type»

In order to isolate the 3D structure of the chromosome during metaphase, the authors used a combination of chromosome conformation capture technologies (3C, 5C and Hi - C) developed by the Dekker lab over the last decade to map the points of contact along the mitotic chromosome in different cell types synchronized to divide at the same time.

Understanding how a particular DNA sequence gives rise to a particular protein provides us with some insight into that protein, but a deeper investigation of how the protein is made, where it is located, and how much of it is present in different cell types is required to enable a true understanding of its function.

Those switches can be both near and far from the gene they regulate and act in different combinations in different cell types to give each cell type a unique genomic identity.

In a paper published earlier this year in Molecular Cell, he and his team explored the activity of the FOS / JUN protein complex, which is expressed across many different cell types in the brain but appears to regulate unique programs in each different cell type.

In the different cell types, the loops begin and end at different specific chromosomal locations, so each cell line's genome appears to have a unique population of loops.

She adds that it is also unclear why distinct patterns of these sites are observed in different cell types and under different drug treatments.

The number of receptors for the neurotransmitter in the brain amounts to 14, occurring in different cell types.

Christian Seiser says: «Our results highlight that it is crucial to understand the individual role the various HDAC variants in different cell types and hence different types of cancer, before HDAC inhibitors can be used safely as therapeutics.»

«We want to know how this system works in all different cell types and in plants that we are interested in for biofuels.»

This was extremely challenging, since many disparate functions have been attributed to Alix in different cell types.

The epigenome determines how instructions in the genome are carried out in different cell types.

«In TSC, we know that in different cell types, the mutation causes different effects.»

In recent years, research at Joslin and elsewhere has shown that insulin resistance may work differently in different cell types.

«We compiled a list of the proteins we thought Zika and similar viruses like dengue were using to get inside of cells, and then we looked to see which of these proteins were abundantly present in the different cell types of the developing brain,» said Pollen, who did the work with Tomasz Nowakowski, PhD, and a UCSF graduate student Carmen Sandoval - Espinosa, BS, both in Kriegstein's lab.

Transcription factors are expressed (or made) at different levels in different cell types, and control what genes are expressed in every cell, making sure, for example, that a liver cell remains a liver cell and does not become a neuron.

Expression of Snail represses expression of E-cadherin and induces EMT in different cell types, including breast cancer cells [36, 37].

All cells in the human body contain these bases in exactly the same order, but different genes are expressed in different cell types, allowing them to carry out their specialized functions.

Understand the molecular mechanisms involved in different cell types and organisms to explain the differences in efficiencies

\ n \ n - Whether one needs the same cocktail of genes in every different cell type to get to the same stage of potency remains to be seen.

In the different cell types of the body, different protein producing genes are active or inactive, and many medical conditions also depend on altered activity of specific genes.

Not exact matches

The goal here is to use «single - cell sequencing to understand how many different cell types there are in the human body, where they reside, and what they do,» as Nature reports.

The average functional protein in a «simple» cell contains 200 amino acids (from the 20 different types).

No, you say that microscopic human life is worthless in sperm and sacred when combined with a different type of cell a couple inches away.

Only a special systemic order of atoms in certain molecules of different types of brain cells, steady activity of these cells and excitations coming from sensoric nerves and running to associative and motoric centers are the basis of the peculiarity of brain function.

Our powers of color vision derive from cells in our eyes called cones, three types in all, each triggered by different wavelengths of light.

The researchers thought this ability to switch between different cell types could explain why they can spread so easily around the body; switching cell type effectively disguises the cells in different tissues.

But there can be several different types of cell in a uterine carcinosarcoma tumor, including ones that are not usually found in the uterus.

«Now that we've confirmed the human relevance of our findings, our future goal is to better understand the roles of the different cell types in psychiatric and neurological disorders, and to determine if targeting these cells can actually help treat seizures,» concluded Paz.

These cells, which can become several different types of blood cells, are similar to the specialized stem cells found in bone marrow that can churn out new blood cells.

This finding reinforced the notion that, in addition to their distinct physiological functions, the two cell types have very different roles in disease.»

In a new study published in Cell Reports, scientists at the Gladstone Institutes identified different types of neurons in a brain region called the reticular thalamuIn a new study published in Cell Reports, scientists at the Gladstone Institutes identified different types of neurons in a brain region called the reticular thalamuin Cell Reports, scientists at the Gladstone Institutes identified different types of neurons in a brain region called the reticular thalamuin a brain region called the reticular thalamus.

«What this research shows is that they're using the same cell types with the same kinds of connections we see in the neocortex, but with a very different kind of organization.»

«The regulation of imprinted methylation results in these very consistent patterns in different tissues and even in a cell - type dependent manner.

In the journal Biomaterials, the team reports culturing cells to make extracellular matrix (ECM) of two types and five different alignments with the strength found in natural tissue and without using any artificial chemicals that could make it incompatible to implanIn the journal Biomaterials, the team reports culturing cells to make extracellular matrix (ECM) of two types and five different alignments with the strength found in natural tissue and without using any artificial chemicals that could make it incompatible to implanin natural tissue and without using any artificial chemicals that could make it incompatible to implant.

«Each area of the brain is different with distinct cell types and connectivity, so if we can confirm that one area of circuitry is more involved in a particular symptom than another, we may eventually be able to treat a depression patient more efficiently than treating everyone the same way.»

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

The project's goals were to explore and describe the range of epigenetic changes that take place in bone marrow as stem cells develop into different types of mature blood cell.

Julius's team compared gene activity in different types of nerve cell from diamondback rattlesnakes, which all have shallow pits on their faces that detect heat.

Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.

Without the regulatory influence of PD - 1, the over activated and over stimulated T cells result in disruption of a crucial balance between different T cell types that leads to an overall greatly reduced immune response.

Plath's team found that the changes that happen in cells during reprogramming occur in a sequential stage - by - stage manner, and that importantly, the stages were the same across all the different reprogramming systems and different cell types analyzed.

This system plays a major role in the regulation of gene activity, and enables the selective expression of different functions in differentiated cell types.

Since pseudouridine modifications may affect various RNA molecules in different types of normal and malignant cells, «our discoveries pave the way for future avenues of research aimed at exploring the role of pseudouridine in human development disease,» concludes Cristian Bellodi.

They focused on four different types of mice, each of which made GFP in a single type of retinal ganglion cell.

They found that depending on the cell of origin, mutations in PIK3CA and p53 induced very different types of tumors.

The researchers believe this is the first 3D in vitro cardiac tissue with three cell types that can beat together as one entity rather than at different intervals.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

Smider and colleagues took serum — blood with the cells removed, leaving antibodies behind — from four immunized cows and tested it against different types of HIV virus in a test tube.

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

In their latest study, they tested compounds against cells from nine different types of human cancer, including common types affecting blood, colon, breast, prostate, ovaries, kidneys, and lungs.