Sentences with phrase «in experimental animal models»

Studies in experimental animal models have now not only stressed the importance of OX40 and OX40L for autoimmune and inflammatory disease manifestations, but shown that inhibiting this interaction can be useful therapeutically.

Not exact matches

He had no animal model of the infection to use in his studies — rats and mice are not susceptible — so he famously used an experimental subject that did not require ethics approval or special funding: himself.

In order to answer the question if animals are capable of mental time travel, the researchers relied on published experimental studies and matched the results with their model.

Stories on how making lab animals happy may make them better experimental models, and the chemistry that's happening in the air and on surfaces in our homes

Included are talks on mechanisms of aging in a wide range of established and non-traditional animal models with the key objective to enhance understanding of the basic biology behind experimental and lifestyle manipulations thought to have direct translational application to human aging.

As an experimental approach, I believe in the need for the combined molecular, behavioural and neuropathological / neuroanatomical study of animal models of disease and CNS dysfunction.

Experimental animal models have been used to investigate many aspects of the clinical disease such as the sex bias in myocarditis where testosterones in males promote autoimmunity in the heart while estrogens in females suppress virus infection and autoimmunity.

If the marriage of stem cells and CRISPR follows a similar path, it might not be long before pigs have enough Homo sapiens in them not only to grow human hearts, lungs, livers, and kidneys for transplant but also to model human diseases more closely than current lab animals do and to test experimental drugs.

Once this work is completed, a second stage is committed, in which researchers of I - Stem, in collaboration with specialists in animal models of diseases targeted by the therapeutic explore the effects of experimental transplantation of cells obtained laboratory.

Having previously published data on a variety of experimental mAbs against AS species in animal models -LRB-[16,20]; possibly [21]-RRB-, Prothena's Dale Schenk presented new data on additional experimental antibodies at SENS Research Foundation's Rejuvenation Biotechnology 2014 conference, roughly contemporaneous to its publication, [22] along with information specific to the humanized candidate PRX002, which is now being advanced into clinical trials.

This week, what the researchers from NIAID (Nature Medicine) and Scripps / J & J (Science) showed is that experimental vaccines made from the stem region only can be broadly protective in several animal models.

This core technology facility, which is shared between the two centres, IFOM and IEO, offers advanced experimental methodologies in nanotechnology (DNA arrays), bioinformatics, robotics, proteomics, structural biology and animal models.

In this study, we investigated whether mild analgesics have effects that manifest as male reproductive disorders using a human prospective birth cohort and experimental animal models (Fig. 1).

Moreover, oral Mycobacterium vaccae, a soil - based microorganism widely distributed in nature, which can easily find its way onto edible plants, has been shown in experimental models to improve cognitive function and diminish anxiety - like behavior among animals [93].

In the mouse model of MS, experimental autoimmune encephalomyelitis (EAE), positive effects of modified fasting and ketogenic nutrition on disease onset and clinical course in animals have been observed in several studieIn the mouse model of MS, experimental autoimmune encephalomyelitis (EAE), positive effects of modified fasting and ketogenic nutrition on disease onset and clinical course in animals have been observed in several studiein animals have been observed in several studiein several studies.

Alpha - lipoic acid (ALA), a naturally occuring compound and a radical scavenger was shown to enhance glucose transport and utilization in different experimental and animal models.

Moreover, models of experimental carcinogenesis in animals have shown the potential to modify a number of metabolic actions and steps in the cell cycle in a way that early events in the cascade of cancer development may be counteracted while stages of progression may be slowed down.

She has expertise in the biology of the whole animal, spontaneous disease manifestations in both human and non-human animals, and in experimental disease models in the laboratory setting.

Although experimental and clinical evidence suggest that endogenous sex hormones influence bone sarcoma genesis, the hypothesis has not been adequately tested in an appropriate animal model.