Sentences with phrase «in filaggrin»

Up to 10 percent of normal individuals carried mutations in the filaggrin gene in these northern nations, in contrast to much lower mutation rates in southern European, Asian and African populations.

Infants were also screened for mutations in the filaggrin (FLG) gene, which codes for a key skin barrier protein.

Not exact matches

A new report by researchers in the Perelman School of Medicine at the University of Pennsylvania found that loss - of - function mutations to Filaggrin - 2 (FLG2), a gene that creates a protein responsible for retaining moisture and protecting the skin from environmental irritants, were associated with atopic dermatitis in African American children.

Previous studies have shown than those of African descent do not usually carry a mutation to the filaggrin gene (FLG) that has been associated with the risk of onset and persistence of AD in those of European and Asian ancestry.

Filaggrin, a key protein in skin barrier function, is deficient in adults.

The deficit of filaggrin has been blamed for the poor skin barrier in eczema.

In contrast to adults, however, the skin of young children with eczema was found to have plenty of filaggrin, despite its poor barrier function and skin thickening that is comparable to skin of adults with eczema.

He recently has focused on a specific skin - barrier protein called filaggrin, which is broken down into a molecule called urocanic acid — the most potent absorber of UVB light in the skin, according to Elias.

Moreover, higher filaggrin mutation rates, which result in a loss of urocanic acid, correlated with higher vitamin D levels in the blood.

Filaggrin plays a critical role in the skin barrier integrity.