Sentences with phrase «in follicle stem»

They then showed that removing Tregs from the skin significantly reduced Notch signaling in follicle stem cells, and that replacing Tregs with microscopic beads covered in Jag1 protein restored Notch signaling in the stem cells and successfully activated follicle regeneration.

Using a nuclear protein expressed in follicle stem cells (FSCs), the researchers found that castor, which plays an important role in specifying which types of brain cells are produced during embryonic development, also helps maintain FSCs throughout the life of the animal.

Not exact matches

Nishimura's team proposes that the same process leads to the reduction in stem cells in the follicles of older people, especially as DNA damage accumulates as we age.

Prof. Jean - Christophe Marine (VIB - KU Leuven): «Unexpectedly, this ability to divide and contribute to melanoma development contrasted with the activities of other cell populations, such as melanocyte stem cells found in hair follicles, for instance.

During the last decade, some researchers have claimed that primordial follicles in adult mouse ovaries turn over and that females use adult germ - line stem cells to constantly resupply the follicle pool and sustain ovulation.

Their research showed that primordial follicles are highly stable, and that germ - line stem cell activity can not be detected, even in response to the death of half the existing follicles.

What's more, they identified Cas as a critical, tissue - specific target of Hh signaling, which not only plays a key role in maintaining follicle stem cells but also assists in the diversification of their progeny.

Earlier work hinted that skin follicles harbor stem cells kept in reserve to replace epidermal cells when they die.

However, these poisons can also do significant harm to other dividing cells such as those found in the stomach lining and in hair and nail follicles, as well as the blood and immune stem cells in the bone marrow.

«By analyzing mice with the WNT10A mutation, as well as tissues from human patients with WNT10A mutations, we found that WNT10A regulates the proliferation, but not the maintenance, of stem cells in hair follicles,» said Sarah Millar, PhD, vice chair for Basic Research in the Department of Dermatology.

For example, in both the blood - cell - producing and the hair - follicle niches, different stem cell types need to coordinate their individual production.

What they did not know in detail is what happens after those stem cells move down to the base, or bulb, of hair follicles and which cells in the hair follicles produce SCF — or that cells involved in hair shaft creation make the KROX20 protein, he said.

Scientists already knew that stem cells contained in a bulge area of hair follicles are involved in making hair and that SCF is important for pigmented cells, said Dr. Le, a member of the Hamon Center for Regenerative Science and Medicine.

Stem cells in hair follicles prove the viability of adult stem cells to not only clone, but also possibly create embryonic stem ceStem cells in hair follicles prove the viability of adult stem cells to not only clone, but also possibly create embryonic stem cestem cells to not only clone, but also possibly create embryonic stem cestem cells.

Waves of Wnt signalling spreading from hair to hair activate follicle growth, followed by waves of BMP signalling that shut down the stem cells in these follicles, halting growth.

Several years ago, scientists discovered stem cells that replenished pigment - making cells, called melanocytes, in hair follicles.

The epithelial stem cells, when implanted into immunocompromised mice, regenerated the different cell types of human skin and hair follicles, and even produced structurally recognizable hair shaft, raising the possibility that they may eventually enable hair regeneration in people.

In vitro hair follicles would be useful, so would blood stem cells.

Almost 100 research teams around the world have now used these special mice to help find adult stem cells in hair follicles, liver, muscle, and other tissues.

In Vivo Monitoring of Survival and Proliferation of Hair Stem Cells in a Hair Follicle Generation Animal ModIn Vivo Monitoring of Survival and Proliferation of Hair Stem Cells in a Hair Follicle Generation Animal Modin a Hair Follicle Generation Animal Model

The stem cells in the bulge are multipotent epithelial stem cells, and can become, or differentiate into, all the epithelial cell types in the follicle (including hair follicles, epidermis, and sebaceous glands)(Oshima et al., 2001).

Within a hair follicle, there are stem cells that reside in an area called the hair follicle «bulge,» which is a small compartment located where the outer root sheath meets the arrector pili muscle (see Hair Follicle follicle, there are stem cells that reside in an area called the hair follicle «bulge,» which is a small compartment located where the outer root sheath meets the arrector pili muscle (see Hair Follicle follicle «bulge,» which is a small compartment located where the outer root sheath meets the arrector pili muscle (see Hair Follicle Follicle figure).

These five types of stem cells are described in the Discovery database as a general dental pulp stem cell population, which includes the following stem cell types: dental pulp stem cell (DPSCs), stem cells from exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), stem cells from apical papilla (SCAP), and dental follicle progenitor cells (DFPCs).

However, earlier this month a study by George Cotsarelis at the University of Pennsylvania School of Medicine and colleagues published in The Journal of Clinical Investigation (Garza et al., 2011) revealed that patients with AGA actually had had a normal amount of follicle stem cells in their scalps.

Title: Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin Authors: Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgård R, Clevers H Date: March 2010 Publication Details: Science.

«Engineering blood vessels for bypass surgery, promoting the formation of new blood vessels or regenerating new skin tissue using stem cells obtained from the most accessible source — hair follicles — is a real possibility,» said Stelios T. Andreadis, Ph.D., co-author of the paper in Cardiovascular Research and associate professor in the Department of Chemical and Biological Engineering in the UB School of Engineering and Applied Sciences.

They conducted a study in mice and found that the stem cell that produces all the different cells of the skin actually lives in hair follicles.

In the current paper, the UB researchers demonstrate that stem cells isolated from sheep hair follicles contain the smooth muscle cells that grow new vasculature.

Melanocytes have the capacity to respond to a diverse number of extracellular signals, including UVR, endocrine signaling cascades that occur during pregnancy, micro-environments of the stem cell hair bulge vs. differentiated hair follicle niches, and hypoxic conditions found in metastatic melanoma tumors.

Your hair — or lack of hair — is the result of a lifelong tug - of - war between activators that wake up, and inhibitors that calm, stem cells in every hair follicle on your body, according to Cheng - Ming Chuong, M.D., Ph.D., of the University of Southern California (USC).