Sentences with phrase «in gene dosage»

Genetic hybridization has been demonstrated to yield dramatic structural genomic variation, but whether such changes in gene dosage impact gene expression has not been formally investigated.

The results suggest that subtle changes in gene dosage across many genes, caused by the change in chromosome numbers, can promote alternate behaviors.

Not exact matches

After determining the proper dosage of tamoxifen — an early trial resulted in a number of mouse deaths due to overactivation of Mecp2 — researchers settled on a four - week regimen of ramping up the gene's function.

Because this imprinting affects hundreds of genes that are non-coding, including microRNAs and non-coding RNAs, it's a very interesting fine - tuning mechanism for the dosage of gene expression in the brain and elsewhere in the body.»

Particularly influential were last year's ruling in Association for Molecular Pathology v. Myriad Genetics Inc. that naturally occurring human genes can not be patented and the 2012 Mayo v. Prometheus decision, which invalidated a patent on a method of adjusting drug dosage using measures of blood metabolites because it relied on a «law of nature.»

In accordance with the gene dosage, a further reduction of up to 70 % of the wt level was observed in hemizygous XpdTTD / KO cellIn accordance with the gene dosage, a further reduction of up to 70 % of the wt level was observed in hemizygous XpdTTD / KO cellin hemizygous XpdTTD / KO cells.

Leukemia in gene therapy trials: a question of vectors, inserts and dosage?»

In studying the regulation of gene dosage, his lab described the first known biological role of a microRNA in the mammalian system, ultimately revealing a network of microRNAs that titrate the dose of key cardiac gene networks that dictate cell fate and differentiatioIn studying the regulation of gene dosage, his lab described the first known biological role of a microRNA in the mammalian system, ultimately revealing a network of microRNAs that titrate the dose of key cardiac gene networks that dictate cell fate and differentiatioin the mammalian system, ultimately revealing a network of microRNAs that titrate the dose of key cardiac gene networks that dictate cell fate and differentiation.

A hallmark of the Notch pathway is its gene dosage sensitivity, such that small differences in the amount of Notch activity can cause aberrant cell fate choices and T - cell leukemia.

«Gene mutations that cause congenital heart disease lower the levels of these transcription factors by half, and we've shown that the dosage of these factors determines which genes are turned on or off in a cell.

(2) Studying the evolution of gene expression and dosage compensation in Drosophila.

We are also applying CRISPR / Cas9 - mediated genome engineering to develop novel mouse models in order to explore the impact of gene dosage alterations on tumor development in vivo.

By utilizing paired genome - wide high - throughput DNA sequencing (DNA - seq) with RNA - seq, we found that gene dosage, at the level of individual genes or chromosomal «somy» (a general term covering disomy, trisomy, tetrasomy, etc.), accounted for greater than 85 % of total gene expression variation in genes with a 2-fold or greater change in expression.

Like Page's group, the Swiss team also found that Y chromosome genes were expressed in a variety of tissues beyond those involved in sexual development and are dosage - dependent.

Increased gene dosage has been observed in males with non-syndromic mild to moderate ID with speech delay.

Leishmania lacks classical regulation of transcription at initiation through promoters, so aneuploidy could represent a major adaptive strategy of this parasite to modulate gene dosage in response to stressful environments.

Here we show that the predominant mechanism determining transcript abundance differences (> 85 %) in Leishmania tropica is that of gene dosage at the level of individual genes or chromosomal somy.