Sentences with phrase «in gene expression associated»

While there are noticeable changes in gene expression associated with PMI, we nonetheless found that the characteristic transcriptional signature of tissues remains largely intact through the PMI intervals considered here.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

Not exact matches

A new study in Biological Psychiatry found that heroin use is associated with excessive histone acetylation, an epigenetic process that regulates gene expression.

Scans showed remodeled DNA methylation patterns in the low - fat group, which changed gene expression associated with fat metabolism and inflammation in the liver; there was less fat accumulation and inflammation in the liver.

This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.

Our data indicate that gene expression is coordinately regulated, such that states of increased proliferation are associated with widespread reductions in the 3 ′ UTR - based regulatory capacity of mRNAs.

Horvath and Tell's research is the first reported study to compare breast cancer subtypes and gene expression patterns associated with STAT3 in the tumors of human patients.

«This miRNA suppresses expression of HMGA1, a gene that was shown in previous studies to be associated with prostate cancer progression and recurrence,» says Leung.

Borrelli said they observed a remarkable decrease in expression levels of some 2,000 genes in this area, coupled with a widespread increase in modifications of basic DNA proteins called histones — particularly those associated with reduced gene activity.

Its appearance following starvation and other stresses is associated with changes in the expression of over 500 genes, most prominently genes for the structural RNAs that are components of the ribosome — the enzyme responsible for protein synthesis.

The title of the paper is «Bioinformatic analysis reveals a pattern of STAT3 - associated gene expression specific to basal - like breast cancers in human tumors.»

Once again, they saw that methylation of a single spot in the serotonin transporter gene was associated with lower levels of serotonin transporter expression in the amygdala.

These products are designed to alter the expression of target genes in the body, suppressing expression of genes associated with disease, or restoring expression of genes required for health.

Animal studies have suggested that overactivation of TLR7 plays a role in lupus, and a gene variant that increases expression of the receptor has been associated with increased lupus risk in human patients.

The new research focused on just nine genes, those most strongly associated with autism in recent sequencing studies, and investigated their effects using precise maps of gene expression during human brain development.

«We found that zinc oxide (ZnO) nanoparticles at doses that are relevant to what you might normally eat in a meal or a day can change the way that your intestine absorbs nutrients or your intestinal cell gene and protein expression,» said Gretchen Mahler, associate professor of bioengineering.

«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments of DNA to the end of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor in the Gene Expression and Regulation program of Wistar's NCI - designated Cancer Center.

Douglas Thomas, associate professor of medicinal chemistry and pharmacognosy at UIC, and co-workers discovered that nitric oxide plays an important role in epigenetics — heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.

It's not that methylation doesn't do anything at all — in fact, the researchers found that it is primarily associated with genes that serve crucial functions for workers and queens alike, suggesting that DNA methylation might contribute to the stable expression of so - called household genes.

The variant lies near a gene called telomerase RNA component, or TERC, and earlier studies in animals have shown that low TERC expression is associated with shorter telomeres, and faster biological aging.

The results of the study challenge the model that comparing mean gene expression in adjacent normal and cancer tissues is the best approach to identifying cancer - associated genes.

«It also affected the expression of certain genes in the brain that are involved in «neuroplasticity», which may be associated with memory impairment,» says Morris.

The investigators also measured gene expression of postvaccinated cervical cells in three of the patients and found increased expression of several genes (CXCR3, Tbet and IFNβ) associated with activation of the immune system.

To investigate, they measured mRNA levels associated with the expression of 23,000 genes in human brain tissue.

But new research presented today at the American Physiological Society (APS) annual meeting at Experimental Biology 2017 in Chicago suggests that normal levels of vitamin A within a high - fat diet can negatively affect expression of liver genes associated with glucose and fat metabolism.

Surprisingly, more than 80 percent of the dependencies with biomarkers were associated with changes (up or down) in a gene's expression.

«The exciting thing here is the expansion of a gene family associated with expression in specific neurons,» says Evan Eichler, a geneticist at the University of Washington, Seattle.

Mao's study examined mitochondria - associated gene expression in the mouse eye tissue and found significant changes in several genes involved in oxidative stress response.

Their synergy with vitamin D to increase CAMP gene expression was significant and intriguing,» said Adrian Gombart, an LPI principal investigator and associate professor in the OSU College of Science.

Previous studies have shown a physiologic role for vitamin D in liver function, but «it was our discovery of high levels of vitamin D receptor (VDR) in the stellate cell that led us to consider it as a possible off switch for liver fibrosis,» says lead author Ning Ding, a research associate in the Gene Expression Laboratory.

To work out the genetic basis, Duke University postdoctoral associate Bob Fitak and biology professor Sönke Johnsen and colleagues investigated changes in gene expression that take place across the rainbow trout genome when the animal's magnetic sense is disrupted.

In the current study, the researchers used infradian cyclic locomotor activity in the mutant mice as a proxy for mood - associated changes, and examined their molecular basis in the brain by conducting prediction analyses of the gene expression datIn the current study, the researchers used infradian cyclic locomotor activity in the mutant mice as a proxy for mood - associated changes, and examined their molecular basis in the brain by conducting prediction analyses of the gene expression datin the mutant mice as a proxy for mood - associated changes, and examined their molecular basis in the brain by conducting prediction analyses of the gene expression datin the brain by conducting prediction analyses of the gene expression data.

So, the inevitable next question was, are the connectivity and gene expression differences of the cells associated with their roles in processing local and global cues?

Our primary aim is to identify subgroups of rNB patients who have potentially targetable genetic (ALK, MAPK pathway, Metabolic - related genes) and / or immunologic (tumor - associated macrophage infiltration and / or programmed death ligand [PD - L1] expression) biomarkers in rNB.

• CpG methylation status quantification PyroMark ID provides highly reproducible quantification of methylation frequencies in individual consecutive CpG sites, enabling accurate measurement of even small changes in methylation levels that are associated with deregulation of gene expression and tumorigenesis.

With respect to the host's transcriptome, alcohol feeding was associated with down - regulation in gene and protein expression of bactericidal c - type lectins Reg3b and Reg3g in the small intestine.

In terms of the potential impact of the risk - associated variants, about half the risk for both disorders appears to be accounted for by variants already known to influence the expression of genes in the braiIn terms of the potential impact of the risk - associated variants, about half the risk for both disorders appears to be accounted for by variants already known to influence the expression of genes in the braiin the brain.

In order to expand the analysis of calcification associated genes, the gene expressions of S. pistillata's orthologs of galaxin and galaxin - like were analyzed through semi-quantitative real - time PCR (Figs. 5A — 5B and File S1).

We found an excess of gene duplications in the East African lineage compared to tilapia and other teleosts, an abundance of non-coding element divergence, accelerated coding sequence evolution, expression divergence associated with transposable element insertions, and regulation by novel microRNAs.

Scientists in both teams looked at the gene expression associated with each protein.

The evidence of ortholog genes expression which likely associated with Smad proteins, Wnt, TGF - β signaling pathways, and cartilage formation in S. pistillata supports previous reports suggesting that gene regulatory pathways of development and biomineralization processes across the metazoan evolution are considerably conserved (Jackson et al., 2007; Marin et al., 2008).

We use extensive genomic and gene - expression profiling techniques to identify molecules and molecular pathways that mediate the dynamic changes observed in vitro, and which are associated with different clinical outcomes in melanoma patients.

The result was initially surprising, she adds, because it's been shown that promoters with a strong propensity for downstream polymerase - pausing are associated with faster gene expression in response to a developmental signal.

Epigenetics began as a correlative field in which covalent modifications to DNA or histones, the proteins that help package DNA, were associated with gene expression or silencing.

We also identified a «meditation effect» within the regular meditator group, characterized by a distinct network of genes with cellular functions that may be relevant to healthy aging, and this network was associated with increased expression of a number of telomere maintenance pathway genes and an increase in measured telomerase enzymatic activity.

The authors looked at gene expression in a panel of 50 ERBB2 (Her2) positive breast tumors and found that this pattern held up: DNA hypomethylation is associated with decreased gene expression in breast cancer.

Ana got her PhD at ICGEB and Osaka University on strategies for optimization of HBsAg expression in Pichia pastoris under the direction of Dr. Navin Khanna, and she did postdoctoral work woth Prof. Rolf Jessberger at Mount Sinai School of Medicine in New York where she carried out a project aimed at deciphering the mechanisms of gene targeting by recombinant adeno - associated virus in human cells.

Sustained high - level expression of human factor IX (hFIX) after liver - targeted delivery of recombinant adeno - associated virus encoding the hFIX gene in rhesus macaques.

DNA methylation of 266 sites, corresponding to 103 genes, were significantly associated with expression in the discordant twins at q < 0.15 (Supplementary Table 18).

To evaluate whether altered expression of the ABL genes is associated with breast cancer progression and metastasis, we examined the expression of ABL1 and ABL2 in normal and invasive breast tumor specimens using published TCGA (The Cancer Genome Atlas) data sets (14 — 16).