Sentences with phrase «in gene expression caused»

Douglas Thomas, associate professor of medicinal chemistry and pharmacognosy at UIC, and co-workers discovered that nitric oxide plays an important role in epigenetics — heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.

If left unchecked, these changes in gene expression cause the heart to become enlarged, inflamed, and full of scar tissue.

Not exact matches

Alnylam has been developing drugs that target gene expression in order to prevent to production of certain biological material which can cause devastating diseases.

Therefore, we questioned whether PTPRF gene expression might be elevated in Mature Group 2 samples, as PTPRF overexpression could be causing excessive downward modulation of the insulin signaling pathway in the women with lower insulin sensitivity.

In the new research, the UB scientists found they could reverse those social deficits with a very low dose of romidepsin, which, they found, restores gene expression and function using an epigenetic mechanism, where gene changes are caused by influences other than DNA sequences.

They discovered that in the young, more immune cells called monocytes were recruited to the lungs, and that the gene expression profiles of these cells had more inflammatory features, causing greater inflammation and more severe lung injury.

We wanted to understand what types of differences are always there, what is causing them, and what they mean,» says Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and co-senior author, with Kelly Frazer of the University of California, San Diego, on the new paper, which was published in Cell Stem Cell in April 2017.

The Epstein - Barr virus, which infects some 90 % of Americans, may cause changes in gene expression that dramatically increase a person's chance of getting lupus and six other autoimmune disorders, a new study by Harley, now a rheumatologist at the Cincinnati Children's Hospital Medical Center in Ohio, and colleagues shows.

When the protein is mutated in Werner syndrome it disrupts the replication and repair of DNA and the expression of genes, which was thought to cause premature aging.

But in the 1 September issue of the Journal of Clinical Investigation, cardiologist Michael Parmacek and his colleagues at the University of Chicago describe how they deleted two genes from the common cold virus to make it unable to cause any sniffling or fever, then replaced them with a marker gene that turns out an easily detected protein and the SM22 promoter, which turns on expression of genes in smooth muscle cells that surround arteries.

A growing body of evidence suggests that environmental stresses can cause changes in gene expression that are transmitted from parents to their offspring, making «epigenetics» a hot topic.

The researchers found that the blond hair commonly seen in Northern Europeans is caused by a single change in the DNA that regulates the expression of a gene that encodes a protein called KITLG, also known as stem cell factor.

The Epstein - Barr virus (EBV), which infects some 90 % of Americans, may cause changes in gene expression that dramatically increase a person's chance of getting lupus and six other autoimmune disorders, a new study by Harley and colleagues shows.

But when the UPR was chemically activated, Bmal1 stayed low during both light and dark phases, which caused a phase shift in the expression of circadian genes.

Further studies discovered that the BRAF protein could turn on many itch genes, and they showed similar changes of gene expression in mice with chronic itch induced by dry skin and in mice with allergic contact dermatitis, two of the skin conditions that frequently cause people to scratch incessantly.

Using clinical, genetic, and gene expression data as filters to distinguish genes whose copy number alteration causes cancer from those for whom copy number changes are incidental, the team whittled down their list from 14,000 to a more manageable number, each of which they systematically tested using genetic experiments in animals.

In DIPG, this «on» switch for gene expression replaces methylation, or a protective «off» switch for cancer - causing genes.

Dodder, a parasitic plant that causes major damage to crops in the U.S. and worldwide every year, can silence the expression of genes in the host plants from which it obtains water and nutrients.

The team also recently obtained a grant from the National Medical Research Council in Singapore to pursue a study using the probe to examine the relationship between key Parkinson's disease - linked genes and MAO - B expression and activity to further understand the causes of the disease and illuminate the role of MAO - B in this.

«The other thing I think is interesting is that there are not that many cases where people have been able to use gene expression, absent any genetics, to zoom in so precisely on a genetic change that causes an obvious trait,» he added.

Analysis showed that incremental changes in the number of repeats caused non-harmful variations in the expression of the genes regulated by Ssn6.

In this case, the study authors say, differences in gene expression over the course of a day may cause a person's heart to heal more quickly in the afternoon than in the morninIn this case, the study authors say, differences in gene expression over the course of a day may cause a person's heart to heal more quickly in the afternoon than in the morninin gene expression over the course of a day may cause a person's heart to heal more quickly in the afternoon than in the morninin the afternoon than in the morninin the morning.

The first clues that assisted reproduction was causing changes in methylation and gene expression came from animal cloning studies back in 2001, Sapienza says.

Ultimately, these signals change the expression of genes in the cell nucleus, causing the cell to grow abnormally.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

One of the mechanisms driving alterations in gene expression is epigenetic change, where the female is able to change her offspring's genome to cause certain genes to be expressed differently.

Loss of the PBRM1 gene function caused the cancer cells to have increased expression of other genes, including gene pathway known as IL6 / JAK - STAT 3, which are involved in immune system stimulation.

DNA methylation and the change in chromatin structures caused by histone modification are both linked to modification of gene expression.

They remained activated long after the gene expression had turned off or gone down in the control animals, thus confirming the earlier observation that the virus causes the immune system to overreact.

«Our hypothesis was, if a disease is characterized by certain changes in gene expression and if a drug causes the reverse changes, then that drug could have a therapeutic effect on the disease,» he says.

Using this approach, these investigators found that nodes (genes) with high connectivity tend to have lower levels of change in expression than peripheral nodes, consistent with the notion that disease ‐ causing genes are typically not central hubs in a molecular module.

Based on analyses of over 600 drug and breast cancer cell pairings, researchers showed that, for some cells, drug exposure can cause significant changes in gene expression — indicating the successful action of a drug on its target — without affecting cell growth or survival.

In these cases, drug exposure caused significant changes in tumor cells» gene expression profile but had no lasting physical effecIn these cases, drug exposure caused significant changes in tumor cells» gene expression profile but had no lasting physical effecin tumor cells» gene expression profile but had no lasting physical effect.

Epigenetics is the study of changes in organisms caused by modifying gene expression — by alcohol, for example — rather than alteration of the genetic code itself.

These datasets will allow the characterization of how genetically different parasites that cause distinct types of human toxoplasmosis alter the expression of protein - encoding and miRNA - encoding genes in both the human host and the parasite.

Combination of methamphetamine and HIV - 1 gp120 causes distinct long - term alterations of behavior, gene expression, and injury in the central nervous system.

Loss of Vascular Endothelial Growth Factor A (VEGFA) Isoforms in the Testes of Male Mice Causes Subfertility, Reduces Sperm Numbers, and Alters Expression of Genes That Regulate Undifferentiated Spermatogonia.

Hall and Rosbash then discovered a protein, named PER, that was made by the period gene, and figured out how it worked through a feedback mechanism — its own expression in the cell would cause PER to build up in the nucleus and would eventually effectively shut off the period gene, allowing it to cycle on and off on a daily schedule.

Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene expressionexpression

Gata5 a potential diagnostic marker for congenital heart disease The finding also suggests that gata5 could be a potential new diagnostic marker for congenital heart defects, as the researchers demonstrated that gata5 regulates the expression of a gene known as nkx2.5 which, when mutated in humans, causes human congenital heart defects and disease.

We design short interfering RNA (siRNA) molecules that are able to trigger the RNAi pathway and mediate the degradation of specific target messenger RNAs (mRNAs), resulting in the expression of a particular disease - causing gene being inhibited.

Because PMI dependent expression changes are largely tissue - specific, they could confound tissue differential gene expression since the observed effects could be caused by differential response to PMI rather than by differences in tissue biology.

For practical purposes, both mutations and epimutations ultimately harm us in the same way: by causing abnormal gene expression.

In a 2015 Nature Communications paper, Rao, who heads LJI's Division of Signaling and Gene Expression, reported that TET2 / 3 mutations caused myeloid disease resembling acute myeloid leukemia in micIn a 2015 Nature Communications paper, Rao, who heads LJI's Division of Signaling and Gene Expression, reported that TET2 / 3 mutations caused myeloid disease resembling acute myeloid leukemia in micin mice.

Sex differences describe biology - linked differences between women and men, which are caused by differences in sex chromosomes, sex - specific gene expression of autosomes, sex hormones, and their effects on organ systems (Figure 1)(1, 3).

Discovered in the late 1970s, the mechanism, called the unfolded protein response, relies on communication between the ER and the cell nucleus: When misfolded proteins, which can cause stress - related diseases, accumulate in the ER, cells counter the surge by triggering a program of gene expression in the nucleus that raises the abundance of ER proteins that foster protein folding and activates a mechanism that degrades protein clumps.

Our siRNA molecules are designed to target a single mRNA in the cell, only affecting the expression of the disease - causing gene.

So what kind of harm can the changes in gene expression resulting from (epi) mutations cause?

In 2017, it will be joined by Anipath, a platform devoted to the histological analysis of small animal models including phenotyping, diagnosis of morbidity cause, in situ gene expression studieIn 2017, it will be joined by Anipath, a platform devoted to the histological analysis of small animal models including phenotyping, diagnosis of morbidity cause, in situ gene expression studiein situ gene expression studies.

In cancer, mutations occur in a cell's DNA sequence that alter gene expression and cause uncontrolled cell growtIn cancer, mutations occur in a cell's DNA sequence that alter gene expression and cause uncontrolled cell growtin a cell's DNA sequence that alter gene expression and cause uncontrolled cell growth.