Sentences with phrase «in gene expression from»

«It's intuitive that taking a vacation reduces biological processes related to stress, but it was still impressive to see the large changes in gene expression from being away from the busy pace of life, in a relaxing environment, in such a short period of time.

Not exact matches

In the clearest possible case, the ANT - OAR cell would differ from a zygote on all of the parameters noted above: The ANT - OAR cell would have a pattern of gene expression that is clearly distinct from a zygote; it would generate a homogeneous population of cells rather than multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.

This dataset contains millions of genomic sequences from a diverse set of rice varieties that, when combined with phenotyping observations, gene expression, and other information, provides an important step in establishing gene - trait associations, building predictive models, and applying these models to breeding.

This study built on previous research from the Sundrud lab, which showed that when TH17 cells entered the intestine in human tissue samples, they increased the expression of a gene called MDR1.

Even more striking, the gene - expression pattern in the hippocampi of THC - treated aged mice was radically different from that of untreated elderly mice.

In a three - stage meta - analysis, Harvard University neurologist Clemens Scherzer and his collaborators analyzed gene expression in 410 samples taken from patients that either had symptomatic or asymptomatic Parkinson's or were healthy, including 185 samples of substantia nigra — a midbrain region where dopamine neurons are particularly susceptible to degeneratioIn a three - stage meta - analysis, Harvard University neurologist Clemens Scherzer and his collaborators analyzed gene expression in 410 samples taken from patients that either had symptomatic or asymptomatic Parkinson's or were healthy, including 185 samples of substantia nigra — a midbrain region where dopamine neurons are particularly susceptible to degeneratioin 410 samples taken from patients that either had symptomatic or asymptomatic Parkinson's or were healthy, including 185 samples of substantia nigra — a midbrain region where dopamine neurons are particularly susceptible to degeneration.

A team of researchers from BWH has tackled this problem by comprehensively analyzing gene expression and protein distribution in human aortic valves obtained from valve replacement surgery.

He extracted DNA from various species in order to clone fragments of genetic material to look for specific gene expression.

This image shows the metabolic expression of a gene identified by scientists from EPFL in Lausanne and ETH Zürich as being a key player in the development of type 2 diabetes.

Cathy Allen of the Rotunda Hospital in Dublin, Ireland, and colleagues analysed the expression of thousands of genes in blood taken from eight women before they were implanted with an IVF embryo.

The researchers discovered that both major living lineages of birds (the common neognaths and the rarer paleognaths) differ from the major lineages of non-bird reptiles (crocodiles, turtles, and lizards) and from mammals in having a unique, median gene expression zone of two different facial development genes early in embryonic development.

In an additional group of endometriosis samples biopsied from 15 women at the University of British Columbia, the scientists looked specifically for mutations in the KRAS gene, whose expression signals proteins that spur cell growth and replicatioIn an additional group of endometriosis samples biopsied from 15 women at the University of British Columbia, the scientists looked specifically for mutations in the KRAS gene, whose expression signals proteins that spur cell growth and replicatioin the KRAS gene, whose expression signals proteins that spur cell growth and replication.

The most promising chemical — sulforaphane, a naturally occurring compound found in cruciferous vegetables — tamped down glucose production by liver cells growing in culture, and shifted liver gene expression away from a diseased state in diabetic rats.

Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

By day 34 of development, however, the pattern of gene expression was much more similar to control cows derived from artificial insemination, suggesting that these surviving clones were able to implant in the uterus and begin to form a placenta.

To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in samples from six early - stage human tumors.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

Finally, the team identified a network of genes in these regions that exhibit changes in expression when the normal boost from serotonin is lacking, and these changes depended on how long the drug was given.

«It is exciting to find a correlation between brain circuitry and gene expression by combining high quality data from these two large - scale projects,» says David Van Essen, Ph.D., professor at Washington University in St. Louis and a leader of the Human Connectome Project.

For example, cultured cells exhibit rhythmic oscillations in gene expression where there is no input from the master clock.

In a recent attempt, oncologist Todd Golub of the Dana - Farber Cancer Institute in Boston, Massachusetts, and his colleagues collected gene expression profiles, taken from public databases, from 76 tumorIn a recent attempt, oncologist Todd Golub of the Dana - Farber Cancer Institute in Boston, Massachusetts, and his colleagues collected gene expression profiles, taken from public databases, from 76 tumorin Boston, Massachusetts, and his colleagues collected gene expression profiles, taken from public databases, from 76 tumors.

Previous work from Dekker and colleagues had shown that points of interaction along the chromosome influence gene expression and are the reason why different cell types are organized differently in three dimensions.

Ronald Kahn and his colleagues at Harvard Medical School in Boston compared gene expression in brain samples from mice with type 1 or type 2 diabetes against those of healthy mice.

Scientists from the Biogerontology Research Foundation (BGRF), a UK - based charity founded to support aging research and address the challenges of a rapidly aging population, propose a new concept for signalome - wide analysis of changes in intracellular pathways, called OncoFinder, which allows for accurate and robust cross-platform analysis of gene expression data.

«For several years the potential for the use of gene expression data in research and clinical applications has been underappreciated due to the inconsistency of the data coming from the various types of equipment.

But in the 1 September issue of the Journal of Clinical Investigation, cardiologist Michael Parmacek and his colleagues at the University of Chicago describe how they deleted two genes from the common cold virus to make it unable to cause any sniffling or fever, then replaced them with a marker gene that turns out an easily detected protein and the SM22 promoter, which turns on expression of genes in smooth muscle cells that surround arteries.

A growing body of evidence suggests that environmental stresses can cause changes in gene expression that are transmitted from parents to their offspring, making «epigenetics» a hot topic.

In a related paper published online today in Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipIn a related paper published online today in Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipin Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipin Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipin mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tips.

Gene expression is the process by which cells extract information from genes and render it in the form of either protein or RNA molecules.

In collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changeIn collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changein skin cells differed among the Esrp knockouts and found hundreds of significant changes.

In previous studies, Chen - Yu Zhang's group has reported a striking finding that plant miRNAs are ingested from plant diets and pass through the gastrointestinal tract, enter into the blood, accumulate in tissues and regulate endogenous gene expression in animalIn previous studies, Chen - Yu Zhang's group has reported a striking finding that plant miRNAs are ingested from plant diets and pass through the gastrointestinal tract, enter into the blood, accumulate in tissues and regulate endogenous gene expression in animalin tissues and regulate endogenous gene expression in animalin animals.

New markers suggested include total mass of hemoglobin, altered expression of genes related to red blood cell metabolism, ironomics, storage lesions, and the presence of plasticizers from blood bags in athlete urine samples.

That work revealed that after mating, seminal fluid proteins passed from males to females led to changes in gene expression in females and led females to increase egg production, reduce feeding and decrease their likelihood to mate again.

Using breast cancer patient data taken from The Cancer Genome Atlas, molecular biologists Curt M. Horvath and Robert W. Tell used powerful computational and bioinformatics techniques to detect patterns of gene expression in two cancer subtypes.

The researchers also looked at the gene expression of skin cells from people with psoriasis and found decreased expression of the genes involved in pigmentation signaling, correlated with increased amounts of IL - 17 and TNF.

To see whether Lin28 might be a factor in Wilms tumor development, Daley and an international team of collaborators measured the gene's expression in tumor samples from 105 Wilms patients.

This new gene expression data therefore provides additional evidence that the altered behavior of bacteria in space results from decreased gravity driving reduced extracellular transport of molecules.

«To our knowledge, our model is the first in which expression of a single gene in postnatal hair cells results in hair cell survival and hearing preservation in mice that otherwise suffer from age - related and noise - induced hearing loss,» Dr. Chen said.

Researchers from BUSM and the University of Cyprus compared the markers on the surface of the cancer cells to gene expression profile of breast tumors deposited by researchers in international public databases and found that a molecule named IL13RA2 (IL13R alpha2) was abundant in metastatic or late - stage BLBC.

When the team measured gene expression first in the stem cells, and then re-evaluated the cells once they had become neurons, very specific differences emerged between the cells derived from bipolar disorder patients and those without the condition.

The mGlu2 decrease, they determined, resulted from an epigenetic change, which affects the expression of genes, in this case the gene that codes for mGlu2.

Also from previous work, they knew the genes whose expression within the transition zone was higher than elsewhere in the cell (indicating that they were being «turned on» for this specific purpose).

In cells grown on flat culture dishes, the expression of thousands of genes didn't match up with their normal patterns, explaining why the cells from those dishes had been unable to generate new hair follicles.

In the Nature Methods paper, Corrada Bravo, UMD computer science doctoral student Florin Chelaru, and undergraduate research assistants from Williams College in Mass. and Washington University in St. Louis used Epiviz to visualize and analyze DNA methylation and gene expression data in colon canceIn the Nature Methods paper, Corrada Bravo, UMD computer science doctoral student Florin Chelaru, and undergraduate research assistants from Williams College in Mass. and Washington University in St. Louis used Epiviz to visualize and analyze DNA methylation and gene expression data in colon cancein Mass. and Washington University in St. Louis used Epiviz to visualize and analyze DNA methylation and gene expression data in colon cancein St. Louis used Epiviz to visualize and analyze DNA methylation and gene expression data in colon cancein colon cancer.

Using a fluorescent protein to detect Rgs16 expression, the investigators found that this gene is induced by pancreatic tumor formation starting from its earliest manifestation as ductal neoplasm all the way to advanced solid tumor in a spatially and temporally coincidental manner.

What we were surprised to find out was that the real differences we could detect in terms of when we did the swap experiments to say which yeast could outperform the other — what we learned was that the GAL1 gene, that the part [of] that, the DNA sequence is outside of the GAL1 gene, it acts as a switch to turn up or turn down GAL1 expression, that had evolved considerably from the ancestral situation; and same for the GAL3.And then what had happened was that each function had been optimized, that GAL3 had sort have been tuned to be sort of a loosely regulated kind of available anytime sensor of galactose and GAL1 had evolved to be an incredibly tightly regulated, in fact, it's the most tightly regulated gene you know of in yeast.

But the researchers found no significant changes in the expression of genes known to be involved in calcification from prior studies comparing strains with dramatically different calcification levels.

ONC201 may inhibit cancer stem cell self - renewals by altering their gene expression, according to a study published August 2, 2017 in the open - access journal PLOS ONE by Varun Vijay Prabhu from Oncoceutics, Inc., USA and colleagues.

Further research could test these cancer stem cell gene expression at the RNA and protein level in circulating tumor cells and biopsies from patients on trial.