Sentences with phrase «in gene expression occurs»

A distinctive pattern of changes in gene expression occurs in those RA patients who have a good - response to a TNF inhibitor at three months, but not in non-responders

Not exact matches

Thus RNA self - splicing can occur at a rate sufficient to support gene expression in a prokaryote, despite the likely presence of ribosomes on the nascent RNA.

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

The most promising chemical — sulforaphane, a naturally occurring compound found in cruciferous vegetables — tamped down glucose production by liver cells growing in culture, and shifted liver gene expression away from a diseased state in diabetic rats.

Biomolecular model based on the gene expression data analyses support the reduction of glucose molecules (blue gradient) and acid buildup (gold gradient) proposed to occur in the boundary layer around the cell.

For mosquito transmission to occur, the sexual form gametocytes, which are structurally distinct and have a very different program of gene and protein expression, have to form continually in the blood on a 2 - day cycle.

The axiom, «growing like a weed,» takes on new meaning in light of changes in gene expression that occur when weeds interact with the crops they infest, according to plant scientist Sharon Clay.

In aging, this gene expression presumably occurs to compensate for the accumulation of protein damages; during diapause, the same genes may be activated to prepare the whole embryo to catch up with the interrupted development and be ready to hatch as the rainy season starts.

«We provide the first evidence that the PPARα - dependent gene Fgf21 demethylation occurs in the postnatal mouse liver, and once established it persists into adulthood and exerts long - term effects on the magnitude of gene expression response to environmental cues, which may account in part for the attenuation of diet - induced obesity (Figure).»

The brain attempts to adapt and respond to those challenges and that occurs in large part through changes in expression of brain genes through epigenetic mechanisms.

Gene moonlighting can occur merely through changes in expression, which may result from as little as a single mutation; it does not require the meandering process of random alteration and selection implied by the duplication and neofunctionalization model.

«This is because while both cell types show hydroxyurea - induced gene expression, collision with replication occurs differentially because replication forks have progressed to different extent in these cells,» said Feng.

The two breeds allow scientists to study the impact of drug use and addiction on gene expression and epigenetics in the nucleus accumbens — the brain's «pleasure center,» where response to drugs like cocaine occurs.

Many factors are involved in controlling which genes get transcribed into messenger RNA and when, but RNA binding proteins interact with the messenger RNA itself to regulate gene expression after transcription has occurred.

To determine whether shifts in the balance of anterior and posterior field occurred during fin - to - limb evolution, Onimaru, postdoctoral researcher currently at Sharpe's lab (CRG), and his colleagues carefully compared the expression, function and regulation of genes involved in anterior - posterior patterning in pectoral fins of catsharks, with those of mice.

Analysis of the most aggressive of these cells revealed a pattern of gene expression distinct from that known to occur in breast - to - bone metastasis, as described in an earlier paper by Massagué.

Although the developmental stages they analyzed in the human embryos — gestation weeks 8 to 9 and 17 to 18 — occur before the folds begin to appear, Borrell says, the varying levels of gene expression provide an «instruction for something to occur.»

Correlation of gene expression occurred across lean and obese mice, defining a common transcriptional response to variations in adiposity.

The most significant changes occurred in a gene called RbAp48, whose expression declined steadily with aging across the study subjects.

To examine the functional effects of the ACVR1 c. 617G → A; R206H mutation that occurs in classic FOP patients, we compared the activity of wild - type (c. 617G; R206) and mutant (c. 617A; R206H) ACVR1 expression constructs on expression of the BMP pathway transcriptional target gene inhibitors of differentiation 1 (ID1)(29, 30).

The NIH Common Fund's Library of Integrated Network - based Cellular Signatures (LINCS) program aims to create a network - based understanding of biology by cataloging changes in gene expression and other cellular processes that occur when cells are exposed to a variety of perturbing agents.

The majority of the changes in gene expression, however, occur between 7 and 14 h post-death, with thousands of genes showing differential expression (equally in both directions) relative to pre-mortem samples.

In cancer, mutations occur in a cell's DNA sequence that alter gene expression and cause uncontrolled cell growtIn cancer, mutations occur in a cell's DNA sequence that alter gene expression and cause uncontrolled cell growtin a cell's DNA sequence that alter gene expression and cause uncontrolled cell growth.

His discoveries include insights into how changes in gene expression affect T cell exhaustion, a waning of immune function that occurs in response to chronic viral infection and cancer.

The aim of his research was to use microarray gene expression data in order to characterize ageing in different human tissues and identify the age at which major changes in genetic expression profiles occur.

The study found that the PDMP mathematical model accurately describes the random, or stochastic, dynamics of gene expression in the non-adiabatic regime (where promoter kinetics are slow and fast averaging can not occur).

Alternative splicing has been shown to occur in up to 94 percent of human genes, resulting in expression of different splice forms for each gene.

Kennedy is interested in understanding why reduced gene expression in ribosomes enhances longevity in yeast and worms — ribosomes are tiny organelles that occur within the cell and are involved in the production of proteins.

It is important to distinguish lineage specific gene expression shown here, which occurs at a high level and with a degree of specificity in the different population compartments, to the low level of genome wide transcription observed in ES cells by others [22], or with transcript initiation at many loci noted previously in ES cells [23].

It matters, as far as gene expression is concerned, only if it occurs in a «promoter» region, a sequence of DNA needed to turn a gene on or off.

Results: Target SSTR2 gene expression occurred exclusively in «proinflammatory» M1 macrophages, specific (68) Ga - DOTATATE ligand binding to SST2 receptors occurred in CD68 - positive macrophage - rich carotid plaque regions, and carotid SSTR2 mRNA was highly correlated with in vivo (68) Ga - DOTATATE PET signals (r = 0.89; 95 % confidence interval [CI]: 0.28 to 0.99; p = 0.02).

Naturally occurring loss of function (LoF) mutations that disrupt the gene's function or expression provide an opportunity to understand the long term consequences of genetic deficiency in humans.