Sentences with phrase «in gene expression patterns»

Evaluating changes in gene expression patterns of Kif5b and Psmd6: Are they regulated by GOLGA3?

Not exact matches

In the clearest possible case, the ANT - OAR cell would differ from a zygote on all of the parameters noted above: The ANT - OAR cell would have a pattern of gene expression that is clearly distinct from a zygote; it would generate a homogeneous population of cells rather than multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.

The shared patterns of gene expression in the limbs and phallus are generated in part by a common set of noncoding DNA, also called «elements» or «enhancers,» which act to control gene expression in both of these structures, argues a study published October 1 in Developmental Cell.

Even more striking, the gene - expression pattern in the hippocampi of THC - treated aged mice was radically different from that of untreated elderly mice.

Recent advances in the understanding of cancer have led to more personalized therapies, such as drugs that target particular proteins and tests that analyze gene expression patterns in tumors to predict a patient's response to therapy.

Scans showed remodeled DNA methylation patterns in the low - fat group, which changed gene expression associated with fat metabolism and inflammation in the liver; there was less fat accumulation and inflammation in the liver.

PATTERNS of gene expression in a woman's blood may give a clue as to whether she is likely to get pregnant using IVF.

«By observing neuronal gene expression in these distinct pathways during development, we detected common patterns, as if an underlying genetic language was bringing them together.»

However, microgravity can reduce cell growth, alter gene expression and change the pattern of root growth — all aspects which critically affect plant cultivation in space.

The patterns of gene expression matched and often preceded physiological changes in the intestine, the researchers wrote.

By day 34 of development, however, the pattern of gene expression was much more similar to control cows derived from artificial insemination, suggesting that these surviving clones were able to implant in the uterus and begin to form a placenta.

Traditional strain - selection techniques are supplemented with strain screening, which can involve examining gene - expression patterns through PCR or understanding global gene expression in relation to environmental factors using gene chips.

To identify genes involved in the patterning of adult structures, Gal4 - UAS (upstream activating site) technology was used to visualize patterns of gene expression directly in living flies.

The trick is to run the tape of evolution over again: to intervene in the development of a chicken embryo, for instance, to reverse evolution, rolling back the clock to manifest earlier patterns of gene expression.

Research published this month in Nature Neuroscience identified a surprisingly small set of molecular patterns that dominate gene expression in the human brain and appear to be common to all individuals, providing key insights into the core of the genetic code that makes our brains distinctly human.

Although a bad outcome was possible without the gene expression pattern, patients with the genetic signature were found to survive for less time than those who didn't have it, they wrote in the 9 December online edition of Nature Genetics.

«We discovered that beta blockers largely reverse the pathological pattern of gene expression observed in heart failure,» said Faculty of Science Professor John McDermott, who led the research, along with York U collaborators Professor Gary Sweeney and Professor Jorg Grigull.

Indeed, the group found that the affected gene, named left - right dynein (lrd), comes on in the «node» — a key source of patterning signals — just before the appearance in the mouse embryo of the first known left - right asymmetries, the left - sided expression of two genes called nodal and lefty.

They found that gene expression is different at 209 sites in chronically lonely people and that many of those changes fit a pattern of elevated immune activation, inflammation, and depressed response to infection.

They compared the resulting gene expression patterns in all the parrot brains with neural tracing experiments in budgerigars.

These areas in parrots also show some special patterns of gene expression, which the scientists speculate might explain why some parrots are also able to learn to dance to music.

Sure enough, salmon with a certain pattern of gene expression in their gill tissue were 13.5 times more likely to die than those that didn't carry the «you've not got long to live» signature, as co-author and University of British Columbia (U.B.C.) fish physiologist Tony Farrell puts it.

Another version, the CTC - iChip, rapidly isolates CTCs in a way that does not rely on preidentified tumor antigens, allowing capture of cells with gene expression patterns that may be missed by the antibodies used in the HBCTC - Chip.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

In a related paper published online today in Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipIn a related paper published online today in Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipin Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipin Cambridge and his colleagues compared the gene expression patterns in mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tipin mouse iPS cells derived from white blood cells, muscle precursor cells, immune system cells called B cells, and fibroblasts taken from tail tips.

Researchers have videotaped cultures in which embryos develop but found no visual pattern that hints at which cells are about to sprout, and staining for certain patterns of gene expression has been inconclusive.

It isn't clear exactly why the differences fade, Hochedlinger says, but it may be that the expression of embryonic genes is strengthened as the cells grow in culture, gradually overwriting the cells» old gene - expression patterns.

The scientists then studied the patterns of gene expression in these mice.

In collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changeIn collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changein skin cells differed among the Esrp knockouts and found hundreds of significant changes.

This pattern of gene expression is likely a reaction to reduced glucose availability, supporting the model of reduced movement of molecules in the bacteria's extracellular environment.

A distinctive pattern of changes in gene expression occurs in those RA patients who have a good - response to a TNF inhibitor at three months, but not in non-responders

Horvath and Tell's research is the first reported study to compare breast cancer subtypes and gene expression patterns associated with STAT3 in the tumors of human patients.

The significance of the new model, according to Grange, is that «it enables us to now have a biological understanding of the patterns, the co-expression profiles, seen in the Allen Gene Expression Atlas of the Mouse Brain.»

Using breast cancer patient data taken from The Cancer Genome Atlas, molecular biologists Curt M. Horvath and Robert W. Tell used powerful computational and bioinformatics techniques to detect patterns of gene expression in two cancer subtypes.

The title of the paper is «Bioinformatic analysis reveals a pattern of STAT3 - associated gene expression specific to basal - like breast cancers in human tumors.»

Horvath and Tell observed that there are many clearly visible patterns of common gene expression — where certain genes are turned on and certain genes are turned off — in the basal - like cancers.

In cells grown on flat culture dishes, the expression of thousands of genes didn't match up with their normal patterns, explaining why the cells from those dishes had been unable to generate new hair follicles.

Consequently, the unique gene expression patterns in every tissue dictate its structure and function.

Results show that one night of partial sleep deprivation activates gene expression patterns in peripheral blood mononuclear cells (PBMCs) consistent with increasing accumulation of damage that initiates cell cycle arrest and increases susceptibility to senescence.

When Bordenstein and Brucker compared gene expression patterns in normal and microbe - free offspring, they found significant changes in many of the genes involved in the immune response (Science, doi.org/m87).

Expression patterns of cryptochrome genes in avian retina suggest involvement of Cry4 in light - dependent magnetoreception (cryptochrome expression in zebraExpression patterns of cryptochrome genes in avian retina suggest involvement of Cry4 in light - dependent magnetoreception (cryptochrome expression in zebraexpression in zebra finches).

In collaboration with Prof. Ido Amit of Weizmann's Immunology Department, they analyzed the genomes of 1,500 individual liver cells, establishing patterns of expression for about 20,000 genes in each celIn collaboration with Prof. Ido Amit of Weizmann's Immunology Department, they analyzed the genomes of 1,500 individual liver cells, establishing patterns of expression for about 20,000 genes in each celin each cell.

«Gene analysis adds layers to understanding how our livers function: Tracking gene expression patterns for 20,000 gene in 1,500 cells revealed a mosaic of activities.&raGene analysis adds layers to understanding how our livers function: Tracking gene expression patterns for 20,000 gene in 1,500 cells revealed a mosaic of activities.&ragene expression patterns for 20,000 gene in 1,500 cells revealed a mosaic of activities.&ragene in 1,500 cells revealed a mosaic of activities.»

Understanding the best ways to work with RNA and the various RNA detection methods can help scientists advance our understanding of gene expression patterns and elucidate the roles of different genomic elements in cellular function and dysfunction.

In a 2015 study of 46 people, Bearden found that people with 22q11.2 deletion syndrome who have autism show different patterns of gene expression than do those with the syndrome who have schizophrenia3.

Then, they compared the patterns of gene expression in the resulting neurons with cells taken from autopsied brains.

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

In this project, the researchers used single cell technology to explore gene expression patterns in healthy and diseased heartIn this project, the researchers used single cell technology to explore gene expression patterns in healthy and diseased heartin healthy and diseased hearts.

MEGENA (for Multiscale Embedded Gene Co-expression Network Analysis) projects gene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and AlzheimeGene Co-expression Network Analysis) projects gene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and Alzheimegene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and Alzheimer's.

The gene expression patterns were so similar, in fact, that investigators were able to use them to match up the stages in worm and fly development.