Sentences with phrase «in gene expression studies»

Bloch's colleagues at the National Institute of Environmental Health Sciences tested the oils in gene expression studies on lab - grown human breast cancer cells and found that they could mimic estrogens, the primary female sex hormones, and inhibit androgens, the primary male sex hormones.

Not exact matches

Our study in an animal model found that influenza infection leads to an increase in the expression of muscle - degrading genes and a decrease in expression of muscle - building genes in skeletal muscles in the legs.

Because epigenetics is the real driver of your health status, and diet plays a major role in gene expression (aka epigenetics), at least in this post's animal study!

Neuroscientists have over the past decade uncovered evidence, both in rodent and human studies, that parental caregiving, especially in moments of stress, affects children's development not only on the level of hormones and brain chemicals, but even more deeply, on the level of gene expression.

A new study in Biological Psychiatry found that heroin use is associated with excessive histone acetylation, an epigenetic process that regulates gene expression.

This study built on previous research from the Sundrud lab, which showed that when TH17 cells entered the intestine in human tissue samples, they increased the expression of a gene called MDR1.

The shared patterns of gene expression in the limbs and phallus are generated in part by a common set of noncoding DNA, also called «elements» or «enhancers,» which act to control gene expression in both of these structures, argues a study published October 1 in Developmental Cell.

In one of her experiments she studied gene expression in nematodes subjected to 15 - G pressures, using Ames's human centrifugIn one of her experiments she studied gene expression in nematodes subjected to 15 - G pressures, using Ames's human centrifugin nematodes subjected to 15 - G pressures, using Ames's human centrifuge.

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

RNAScope ISH was developed by Advanced Cell Diagnostics (ACD) Inc., initially for studies of gene expression in animal (and especially human) tissues.

Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.

The study's 31 samples of dog tumors was compared to 40 normal canine tissues samples as a way of estimating the variance in gene expression.

In a new study published in Physiological Genomics, a team of U.S. researchers tracked in detail how this extreme makeover is controlled by changes in gene expressioIn a new study published in Physiological Genomics, a team of U.S. researchers tracked in detail how this extreme makeover is controlled by changes in gene expressioin Physiological Genomics, a team of U.S. researchers tracked in detail how this extreme makeover is controlled by changes in gene expressioin detail how this extreme makeover is controlled by changes in gene expressioin gene expression.

According to Izpisúa Belmonte, who is also a professor at the gene expression laboratories of the Salk Institute for Biological Studies in San Diego, California, CMRB aims to become «a research centre of excellence in south Europe in the line of world - recognized institutions such as the Salk or the Whitehead institutes, where both pre - and postdoctoral researchers receive multidisciplinary training of the highest quality» in stem cell biology and cell regeneration.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

The Epstein - Barr virus, which infects some 90 % of Americans, may cause changes in gene expression that dramatically increase a person's chance of getting lupus and six other autoimmune disorders, a new study by Harley, now a rheumatologist at the Cincinnati Children's Hospital Medical Center in Ohio, and colleagues shows.

To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in samples from six early - stage human tumors.

Prof. Khatri and his team studied the way the immune system responds to infection by looking at gene expression — which genes are active and which are not — and whether there are differences in patients with malaria compared to other infectious diseases.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

According to the researchers, this is the first study to link the extreme and rapid eating - induced changes of the Burmese python's intestines directly to changes in gene expression, and also the first to show how quickly gene expression changed.

This study could help us understand how changing messenger molecule tails could control gene expression in the context of regeneration.

This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.

Visel and his colleagues studied gene expression in a developing mouse embryo, and found 120 enhancers active in cells of the face.

This work provides a proof of principle for a new approach in the study and treatment of cancer: the aberrant expression in a tissue or organ of genes specific to other tissues could become a new tool for establishing a prognosis and personalizing therapeutic care.

Global gene expression studies found that the LPA - treated mice shared many similar molecular markers as those found in humans with schizophrenia.

Their study, in the journal Oncotarget, is the most extensive analysis to date of gene expression's role in ccRCC tumor growth and metastasis.

«Single - nucleus RNA sequencing, droplet by droplet: DroNc - Seq, technology that merges single - nucleus RNA sequencing with microfluidics, brings new scale to gene expression studies in complex tissues.»

Still, he says it would be «reassuring» to see the study repeated with more subjects, and he notes that the work leaves unanswered which comes first, the loneliness or the change in gene expression.

The scientists then studied the patterns of gene expression in these mice.

In this study, a team led by Panos N. Papapanou, DDS, PhD, professor and chair of oral, diagnostic and rehabilitation sciences at the College of Dental Medicine at CUMC, «reverse - engineered» the gene expression data to build a map of the genetic interactions that lead to periodontitis and identify individual genes that appear to have the most influence on the disease.

In a study exploring the molecules controlling osteoclast differentiation in the cancer setting, Ell et al. have identified miRNAs (microRNAs are small noncoding RNAs that regulate gene expression) whose levels were consistently down - or up - regulated in differentiating osteoclastIn a study exploring the molecules controlling osteoclast differentiation in the cancer setting, Ell et al. have identified miRNAs (microRNAs are small noncoding RNAs that regulate gene expression) whose levels were consistently down - or up - regulated in differentiating osteoclastin the cancer setting, Ell et al. have identified miRNAs (microRNAs are small noncoding RNAs that regulate gene expression) whose levels were consistently down - or up - regulated in differentiating osteoclastin differentiating osteoclasts.

Using an innovative crystallization technique for studying three - dimensional structures of gene transcription machinery, an international team of researchers, led by scientists at Penn State, has revealed new insights into the long debated action of the «magic spot» — a molecule that controls gene expression in Eschericahia coli and many other bacteria when the bacteria are stressed.

In previous studies, Chen - Yu Zhang's group has reported a striking finding that plant miRNAs are ingested from plant diets and pass through the gastrointestinal tract, enter into the blood, accumulate in tissues and regulate endogenous gene expression in animalIn previous studies, Chen - Yu Zhang's group has reported a striking finding that plant miRNAs are ingested from plant diets and pass through the gastrointestinal tract, enter into the blood, accumulate in tissues and regulate endogenous gene expression in animalin tissues and regulate endogenous gene expression in animalin animals.

The researchers investigated 16 groups of female and male mice offspring exposed to maternal diet - induced obesity and male hormone excess and studied how these environmental factors affected the mice's behaviour as well as gene expression in the brain.

Horvath and Tell's research is the first reported study to compare breast cancer subtypes and gene expression patterns associated with STAT3 in the tumors of human patients.

«This miRNA suppresses expression of HMGA1, a gene that was shown in previous studies to be associated with prostate cancer progression and recurrence,» says Leung.

The Epstein - Barr virus (EBV), which infects some 90 % of Americans, may cause changes in gene expression that dramatically increase a person's chance of getting lupus and six other autoimmune disorders, a new study by Harley and colleagues shows.

The study shows that even small, tissue - specific changes in the expression of genes can have noticeable morphological effects.

A molecule in cells that shuts down the expression of genes might be a promising target for new drugs designed to treat the most frequent and lethal form of brain cancer, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

Further study revealed that UPB1 regulates the expression of three genes, called peroxidases, which themselves control the distribution of two chemicals, hydrogen peroxide and superoxide, in the root.

Further studies discovered that the BRAF protein could turn on many itch genes, and they showed similar changes of gene expression in mice with chronic itch induced by dry skin and in mice with allergic contact dermatitis, two of the skin conditions that frequently cause people to scratch incessantly.

Animal studies have suggested that overactivation of TLR7 plays a role in lupus, and a gene variant that increases expression of the receptor has been associated with increased lupus risk in human patients.

«For the first time, our study identified detailed gene expression levels in these granules.

When that lab closed she went back to university, working in a biochemistry and molecular biology lab to study gene expression during wine making, but this contract, too, came to an end.

Several studies had already pinned some of the visible abnormalities in clones on the absence of vital molecules that turn gene expression on and off during fetal development.

While previous investigations into the protein's effects have used either mice in which gene expression was knocked out or transgenic animals that expressed human gene variants throughout their lifetimes, the MGH - MIND - led study used a different approach to investigate the effects of introducing the variant forms of the protein into brains in which plaque formation had already begun.

And more recently, molecular studies had suggested that caloric restriction — or compounds that mimicked it — might trigger a cascade of changes in gene expression that had the net effect of slowing ageing.

In the study published in Nucleic Acids Research, the researchers were able to induce and inhibit the expression of genes in mammalian cell cultures and were able to regulate intracellular protein levels using light signalIn the study published in Nucleic Acids Research, the researchers were able to induce and inhibit the expression of genes in mammalian cell cultures and were able to regulate intracellular protein levels using light signalin Nucleic Acids Research, the researchers were able to induce and inhibit the expression of genes in mammalian cell cultures and were able to regulate intracellular protein levels using light signalin mammalian cell cultures and were able to regulate intracellular protein levels using light signals.

We even did gene - expression studies in flies showing that genes in their brains change their level of activity in waking and in sleep.

The new research focused on just nine genes, those most strongly associated with autism in recent sequencing studies, and investigated their effects using precise maps of gene expression during human brain development.