Sentences with phrase «in gene expression with»

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This dataset contains millions of genomic sequences from a diverse set of rice varieties that, when combined with phenotyping observations, gene expression, and other information, provides an important step in establishing gene - trait associations, building predictive models, and applying these models to breeding.

Gene Expression in Cumulus Cells and Correlation with Pregnancy Outcome in Women.

Therefore, we questioned whether PTPRF gene expression might be elevated in Mature Group 2 samples, as PTPRF overexpression could be causing excessive downward modulation of the insulin signaling pathway in the women with lower insulin sensitivity.

They compared changes in gene expression in 37 of them who developed suicidal feelings with previously published work and with post-mortem samples of 26 men who had killed themselves.

A new study in Biological Psychiatry found that heroin use is associated with excessive histone acetylation, an epigenetic process that regulates gene expression.

In subsequent analyses, striking losses in gene expression were observed in genomic regions that had become increasingly methylated with age, whereas regions that had become less methylated showed increases in gene expressioIn subsequent analyses, striking losses in gene expression were observed in genomic regions that had become increasingly methylated with age, whereas regions that had become less methylated showed increases in gene expressioin gene expression were observed in genomic regions that had become increasingly methylated with age, whereas regions that had become less methylated showed increases in gene expressioin genomic regions that had become increasingly methylated with age, whereas regions that had become less methylated showed increases in gene expressioin gene expression.

In the new research, the UB scientists found they could reverse those social deficits with a very low dose of romidepsin, which, they found, restores gene expression and function using an epigenetic mechanism, where gene changes are caused by influences other than DNA sequences.

An international team led by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a new technique for identifying gene enhancers — sequences of DNA that act to amplify the expression of a specific gene — in the genomes of humans and other mammals.

We wanted to understand what types of differences are always there, what is causing them, and what they mean,» says Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and co-senior author, with Kelly Frazer of the University of California, San Diego, on the new paper, which was published in Cell Stem Cell in April 2017.

Cathy Allen of the Rotunda Hospital in Dublin, Ireland, and colleagues analysed the expression of thousands of genes in blood taken from eight women before they were implanted with an IVF embryo.

Scans showed remodeled DNA methylation patterns in the low - fat group, which changed gene expression associated with fat metabolism and inflammation in the liver; there was less fat accumulation and inflammation in the liver.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

First, they did a quantitative analysis of the anatomy of related fossils and extant animals to generate a hypothesis about the transition; next, they searched for possible shifts in gene expression that correlated with the transition.

The team also looked at gene expression before and after exposure and identified 335 genes whose variation in expression correlated with caspase activity.

When the team induced expression of the corresponding gene in the leaves of two other plant species (one closely related to S. lycopersicum and the other more distantly related), both plants reacted to presence of the C. reflexa peptide with increased production of ethylene, and exhibited increased resistance to C. reflexa infestation.

Objective: Research microbiologist with 3 years of postgraduate research in gene expression and metabolism of E. coli would like to apply knowledge within an industry setting.

Traditional strain - selection techniques are supplemented with strain screening, which can involve examining gene - expression patterns through PCR or understanding global gene expression in relation to environmental factors using gene chips.

Prof. Khatri and his team studied the way the immune system responds to infection by looking at gene expression — which genes are active and which are not — and whether there are differences in patients with malaria compared to other infectious diseases.

They did this by testing tissue concentrations of fatty acids in liver, muscle and brain tissue, along with the expression of genes involved in regulating EPA status and its physiological benefits.

At a 0.2 - millimolar sucralose dose similar to the concentration found in the blood of people with high consumption of low - calorie sweeteners — equal to four cans of diet soda per day — the researchers said they observed increased expression of genes that are markers of fat production and inflammation.

They found similar changes in gene expression in the same genes with increased activity of glucose transporters in both the stem cells and the fat cells, Sen noted.

Two distinctive handfuls of short molecules that regulate gene expression have been found in the eye fluid of patients with two distinct types of vision degenerating glaucoma.

Although a bad outcome was possible without the gene expression pattern, patients with the genetic signature were found to survive for less time than those who didn't have it, they wrote in the 9 December online edition of Nature Genetics.

«We discovered that beta blockers largely reverse the pathological pattern of gene expression observed in heart failure,» said Faculty of Science Professor John McDermott, who led the research, along with York U collaborators Professor Gary Sweeney and Professor Jorg Grigull.

They compared the resulting gene expression patterns in all the parrot brains with neural tracing experiments in budgerigars.

This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

Ronald Kahn and his colleagues at Harvard Medical School in Boston compared gene expression in brain samples from mice with type 1 or type 2 diabetes against those of healthy mice.

The tool acts with surgical precision to replace only abundances that have most likely dropped out and can be used in any type of single - cell gene - expression analysis.

The expression of all human genes was analyzed in these tumors and correlated with different clinical parameters.

But in the 1 September issue of the Journal of Clinical Investigation, cardiologist Michael Parmacek and his colleagues at the University of Chicago describe how they deleted two genes from the common cold virus to make it unable to cause any sniffling or fever, then replaced them with a marker gene that turns out an easily detected protein and the SM22 promoter, which turns on expression of genes in smooth muscle cells that surround arteries.

Sure enough, salmon with a certain pattern of gene expression in their gill tissue were 13.5 times more likely to die than those that didn't carry the «you've not got long to live» signature, as co-author and University of British Columbia (U.B.C.) fish physiologist Tony Farrell puts it.

For that reason, Sweeney and Khatri are working with other researchers on a way to engineer the gene expression test to provide results in under an hour.

Dr. Seibold and his colleagues showed that gene expression in the nasal passages overlaps 90 % with genes expressed in the lungs.

Another version, the CTC - iChip, rapidly isolates CTCs in a way that does not rely on preidentified tumor antigens, allowing capture of cells with gene expression patterns that may be missed by the antibodies used in the HBCTC - Chip.

Global gene expression studies found that the LPA - treated mice shared many similar molecular markers as those found in humans with schizophrenia.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

This program, resulting in shorter 3 ′ UTRs, is a characteristic of gene expression during immune cell activation and correlates with proliferation across diverse cell types and tissues.

The theory holds that histone proteins, which combine with DNA to form chromosomes, are more intimately involved in gene expression than their general role of facilitating or hindering gene activation suggests.

«Single - nucleus RNA sequencing, droplet by droplet: DroNc - Seq, technology that merges single - nucleus RNA sequencing with microfluidics, brings new scale to gene expression studies in complex tissues.»

While nicotine and non-nicotine products both produced changes, e-cigarette products without nicotine resulted in even more gene expression changes than products with nicotine, Zelikoff said.

Still, he says it would be «reassuring» to see the study repeated with more subjects, and he notes that the work leaves unanswered which comes first, the loneliness or the change in gene expression.

In a paper published in Nature Methods, postdoctoral fellows Naomi Habib, Inbal Avraham - Davidi, and Anindita Basu; core institute members Feng Zhang and Aviv Regev; and their colleagues reveal DroNc - Seq, a single - cell expression profiling technique that merges sNuc - Seq with microfluidics, allowing massively parallel measurement of gene expression in structurally - complicated tissueIn a paper published in Nature Methods, postdoctoral fellows Naomi Habib, Inbal Avraham - Davidi, and Anindita Basu; core institute members Feng Zhang and Aviv Regev; and their colleagues reveal DroNc - Seq, a single - cell expression profiling technique that merges sNuc - Seq with microfluidics, allowing massively parallel measurement of gene expression in structurally - complicated tissuein Nature Methods, postdoctoral fellows Naomi Habib, Inbal Avraham - Davidi, and Anindita Basu; core institute members Feng Zhang and Aviv Regev; and their colleagues reveal DroNc - Seq, a single - cell expression profiling technique that merges sNuc - Seq with microfluidics, allowing massively parallel measurement of gene expression in structurally - complicated tissuein structurally - complicated tissues.

In collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changeIn collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changein skin cells differed among the Esrp knockouts and found hundreds of significant changes.

Our data indicate that gene expression is coordinately regulated, such that states of increased proliferation are associated with widespread reductions in the 3 ′ UTR - based regulatory capacity of mRNAs.

Horvath and Tell's research is the first reported study to compare breast cancer subtypes and gene expression patterns associated with STAT3 in the tumors of human patients.

«These findings underscore the significance of Gcn5 - regulated gene expression coupled with the metabolic enzyme alpha - KGDH in tumor cell proliferation and formation.»

«This miRNA suppresses expression of HMGA1, a gene that was shown in previous studies to be associated with prostate cancer progression and recurrence,» says Leung.

Borrelli said they observed a remarkable decrease in expression levels of some 2,000 genes in this area, coupled with a widespread increase in modifications of basic DNA proteins called histones — particularly those associated with reduced gene activity.

Its appearance following starvation and other stresses is associated with changes in the expression of over 500 genes, most prominently genes for the structural RNAs that are components of the ribosome — the enzyme responsible for protein synthesis.