Sentences with phrase «in head and neck cancer»

My name is Stuart Hislop and I am a consultant oral and maxillofacial / head and neck surgeon specialising in head and neck cancer and its reconstruction.

This research is funded through Pitt's Specialized Program of Research Excellence grant in head and neck cancer from the National Cancer Institute.

Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial

«We can use viruses like HPV as an entry point to study mutations in head and neck cancer and cervical cancer,» said Krogan.

Through this process, the scientists were able to narrow their search and focus on the genes that were both mutated in head and neck cancer and hijacked by HPV.

A promising avenue of clinical research in head and neck cancer is the use of immune checkpoint inhibitors.

In back - to - back papers published online July 28 in Science, researchers from the Broad Institute, Dana - Farber Cancer Institute, Johns Hopkins Kimmel Cancer Center, the University of Pittsburgh, and the University of Texas MD Anderson Cancer Center have confirmed genetic abnormalities previously suspected in head and neck cancer, including defects in the tumor suppressor gene known as p53.

New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.

«Antacids linked to better survival in head and neck cancer.»

This research is funded through Pitt's Specialized Program of Research Excellence grant in head and neck cancer from the National Cancer Institute.

The effects of the pactamycin analogs, called TM - 025 and TM - 026, were characterized in head and neck cancer cell lines, which cause the eighth most common cancer in the world.

Last time I checked, Meredith Viera isn't a doctor and Nancy Snyderman specializes in head and neck cancer, not obstetrics (not that she writes the story, but you know what I mean).

Previous studies by the University of South Carolina's Lucia Pirisi - Kim Creek research group had reported the existence of an HPV - inactive class in head and neck cancers and raised the possibility that HPV - inactive cervical cancers might originate as virally driven cancers and subsequently act independent of HPV.

Not exact matches

He founded the organization in 2001 after his 21 - year - old daughter Abigail died from head and neck cancer.

She and other colleagues first noticed an odd shift in patient profiles in the late 1990s: younger men were showing up in her clinic, often with no significant history of smoking or heavy drinking, which are risk factors for head and neck cancers.

Even though this is a relatively rare cancer, we know HPV is important in a number of other tumors, including those of the head and neck.

The study, was reported Feb 13 to the 5th International Conference on Innovative Approaches in Head and Neck Oncology (ICHNO) will reduce significantly the number of HNSCC patients who currently undergo selective neck dissection (SND), a procedure which involves removing a group of lymph nodes from the neck in order to try to eradicate those which may have been reached by the cancer.

«New radiotracer helps avoid neck dissection in patients with early head and neck cancer.»

Immunotherapy doubles overall survival and improves quality of life, with fewer side effects, in a treatment - resistant and rapidly progressing form of head and neck carcinoma, reports a large, randomized international trial co-led by investigators at the University of Pittsburgh Cancer Institute (UPCI).

A similar virus, called H101, is already marketed in China to treat head and neck cancers.

Finally, a Calgary, Alberta — based company, Oncolytics Biotech, is testing a reovirus (an RNA virus often found in human lungs but thought to be nonpathogenic) against several types of cancer, including that of the lung and skin as well as head and neck malignancies.

Heeke says the study would be open to people whose tumors have evidence of HRD like those found in this study, which includes bladder, breast, cervix, liver and bile duct, colorectal, endometrial, gastric / esophageal, head & neck, kidney, neuroendocrine, lung, ovarian, pancreas, prostate, sarcoma, and thyroid cancers, as well as gastrointestinal stromal tumors, glioma, melanoma and unknown primary cancers.

In 2011 the National Toxicology Program at the Department of Health and Human Services declared formaldehyde a known human carcinogen, demonstrated by human and animal studies to cause cancer of the nose, head, neck and lymphatic system.

Dr. Islam saw this phenomenon occur in cell culture and in some samples from patients with head and neck cancers.

The man, identified in a medical journal case report only as «Mr. S,» had been on chemotherapy to keep his head and neck cancer in check.

Researchers at Oregon State University are pursuing a new concept in treatment of epithelial cancer, especially head and neck cancer, by using two promising «analogs» of an old compound that was once studied as a potent anti-tumor agent, but long ago abandoned because it was too toxic.

Yang et al. report on one such strategy: Taking the knowledge that an increase in type I interferons (IFNs) correlates positively with clinical outcome in several cancers and that type I IFNs can enhance antitumor immunity in some models, the authors tethered IFN - β to a monoclonal antibody targeting the epithelial growth factor receptor (EGFR), which is approved for use in treating metastatic colorectal cancer and head and neck cancer.

The vaccine may also prevent head and neck cancer, which has been on the rise in recent years.

And although the vaccine has not been proven to prevent head and neck cancers, which can also be caused by HPV, the recent rise in cases of these cancers likely factored into the panel's reasoning for the recommendation, Schaffner saAnd although the vaccine has not been proven to prevent head and neck cancers, which can also be caused by HPV, the recent rise in cases of these cancers likely factored into the panel's reasoning for the recommendation, Schaffner saand neck cancers, which can also be caused by HPV, the recent rise in cases of these cancers likely factored into the panel's reasoning for the recommendation, Schaffner said.

Men who had smoked were nearly twice as likely to die from cancer, especially lung cancer, but there was also an elevated risk of death from cancers of the head and neck, esophagus, stomach, colorectum, liver, pancreas and bladder — all diseases that have been linked to smoking in previous studies, according to the authors.

Specifically, data from the Cancer Genome Atlas showed signatures of APOBEC3 - mediated mutations in the PIK3CA gene of about 40 percent of HPV - positive head and neck cancers, but only about 10 percent of HPV - negative head and neck cancers.

To investigate why checkpoint inhibitors so often stop working, Velculescu; Valsamo Anagnostou, M.D., Ph.D., instructor of oncology at the Johns Hopkins University School of Medicine; Kellie N. Smith, Ph.D., a cancer immunology research associate at the Johns Hopkins University School of Medicine; and their colleagues at the Bloomberg ~ Kimmel Institute for Cancer Immunotherapy studied tumors of four patients with non-small cell lung cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-cancer immunology research associate at the Johns Hopkins University School of Medicine; and their colleagues at the Bloomberg ~ Kimmel Institute for Cancer Immunotherapy studied tumors of four patients with non-small cell lung cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-Cancer Immunotherapy studied tumors of four patients with non-small cell lung cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-CTLA4.

Having only people with head and neck cancers in the study eliminates the variability of a group suffering from different forms of the disease, but it also eliminates information about whether patients with other forms of cancer would show the same results.

The results of the mouse, human and lab studies have been so successful that Dr. Bauman has started a larger clinical trial in volunteers previously cured of head and neck cancer.

Prior research has found that almost all head and neck cancer cells display an over-abundance of the protein, and it had been suggested in the literature as a potential target.

Dr. Bauman also collaborated with senior author Daniel E. Johnson, Ph.D., professor of medicine at Pitt and a senior scientist in the UPCI Head and Neck Cancer Program, to see how the extract performed in mice predisposed to head and neck canHead and Neck Cancer Program, to see how the extract performed in mice predisposed to head and neck cCancer Program, to see how the extract performed in mice predisposed to head and neck canhead and neck cancercancer.

«People who are cured of head and neck cancer are still at very high risk for a second cancer in their mouth or throat, and, unfortunately, these second cancers are commonly fatal,» said lead author Julie Bauman, M.D., M.P.H., co-director of the UPMC Head and Neck Cancer Center of Excellehead and neck cancer are still at very high risk for a second cancer in their mouth or throat, and, unfortunately, these second cancers are commonly fatal,» said lead author Julie Bauman, M.D., M.P.H., co-director of the UPMC Head and Neck Cancer Center of Excelcancer are still at very high risk for a second cancer in their mouth or throat, and, unfortunately, these second cancers are commonly fatal,» said lead author Julie Bauman, M.D., M.P.H., co-director of the UPMC Head and Neck Cancer Center of Excelcancer in their mouth or throat, and, unfortunately, these second cancers are commonly fatal,» said lead author Julie Bauman, M.D., M.P.H., co-director of the UPMC Head and Neck Cancer Center of ExcelleHead and Neck Cancer Center of ExcelCancer Center of Excellence.

«Green chemoprevention requires less money and fewer resources than a traditional pharmaceutical study, and could be more easily disseminated in developing countries where head and neck cancer is a significant problem.»

«Compound in magnolia may combat head and neck cancers: Honokiol, from magnolia bark, shuts down cancer cells in lab.»

Dr. Bauman and her colleagues treated human head and neck cancer cells in the laboratory with varying doses of sulforaphane and a control, and compared them to normal, healthy cells that line the throat and mouth.

According to the National Cancer Institute, at least 3 in 4 head and neck cancers are caused by the use of tobacco and alcohol.

This study, «Final Results of Local - Regional Control and Late Toxicity of RTOG 9003: A Randomized Trial of Altered Fractionation Radiation for Locally Advanced Head and Neck Cancer,» is a multi-institutional, randomized Phase III trial of fractionation in locally advanced head and neck canHead and Neck Cancer,» is a multi-institutional, randomized Phase III trial of fractionation in locally advanced head and neck cCancer,» is a multi-institutional, randomized Phase III trial of fractionation in locally advanced head and neck canhead and neck cancercancer.

«The decrease in the rate of new cancers was unexpected; however, the large database and the long follow - up provided us with a window into information that had not previously been available about the long - term patterns of head and neck tumors and is particularly heartening.

«This study, one of only a few large studies to have follow - up beyond five years, demonstrates that patients who have head and neck cancers and who are being treated with radiation therapy alone have improved local - regional control and no increase in late toxicity when radiation therapy is delivered twice a day in two smaller doses which we call hyperfractionation,» said Jonathan J. Beitler, MD, MBA, FASTRO, lead author of the study and professor of radiation oncology, otolaryngology and hematology / medical oncology at the Winship Cancer Institute of Emory University School of Medicine in Atlanta.

Human papilloma virus (HPV), the culprit behind cervical cancer and some forms of head and neck cancer may hide in small pockets on the surface of tonsils in people not known to carry the virus.

A similar rearrangement of collagen has also been found in breast cancer, head, neck, esophageal and colorectal cancers.

While verified tests exist to detect HPV in people before they develop cervical cancer, the same is not true for HPV - related head and neck cancers, which are expected to outnumber cervical cancer cases by 2020.

It's also known to play a role in a form of leukemia, as well as liver cancer, squamous cell skin carcinomas, squamous cell cancers of the head and neck and other cancers.

A class of therapeutic drugs known as protein kinase inhibitors has in the past decade become a powerful weapon in the fight against various life - threatening diseases, including certain types of leukemia, lung cancer, kidney cancer and squamous cell cancer of the head and neck.

«Given the lack of universal HPV immunization and the potential for the virus to evade the immune system even in individuals with detectable HPV in their blood, our findings could have far - reaching implications for identifying people at risk of developing HPV - related head and neck cancers and ultimately preventing them,» Miller said.