Sentences with phrase «in hematopoietic»

Finally, within the fractionated cell populations, there was evidence for coexpression of lineage specific markers alongside of pluripotency genes, similar to lineage priming described first in hematopoietic stem cells [15].

Hunger SP, Loh KM, Baker KS, Schultz KR.: Controversies of and unique issues in hematopoietic cell transplantation for infant leukemia.

«Programmed cell death, or apoptosis, is very important, particularly in the hematopoietic (blood forming) system, where inhibition of cell death leads to leukemias,» says Whitehead Institute Founding Member Harvey Lodish, who is also a professor of biology and a professor of bioengineering at MIT.

Activating mutations in tyrosine kinases have been identified in hematopoietic and nonhematopoietic malignancies.

The role of conditioning in hematopoietic stem cell gene therapy.

It is well known that HDAC inhibitors are potent anticancer drugs in hematopoietic malignancies, including lymphoma.19 — 21 The aim of using HDAC inhibitors is to restore normal histone modification patterns through inhibition of various components of the epigenetic machinery.22, 23 In B - cell lymphoma, HDAC inhibitors can rescue deficits in histone acetylation induced by EP300 / CREBBP mutations, 24 rendering tumor cells more sensitive to suberoylanilide hydroxamic acid.25 This can explain why chidamide also has favorable efficacy on PTCL - NOS patients bearing EP300 / CREBBP mutations.

Title: Polycomb group proteins in hematopoietic stem cell aging and malignancies Authors: Klauke K, de Haan G Date: 2011 Publication Details: International Journal of Hematology 2011 Jul; 94 (1): 11 - 23

Brummendorf TH, Dragowska W, and Lansdorp PM, Asymmetric cell divisions in hematopoietic stem cells.

Investigators, clinicians, laboratory technicians, clinical research professionals, nurses, pharmacists, administrators, and allied health professional attendees benefit from the full scientific program that addresses the most timely issues in hematopoietic cell transplantation.

As an extension to genetics projects, we now aim to identify and characterize in greater depth genes implicated in hematopoietic development in the EU FP7 - funded BLUEPRINT project, which will generate reference genomes and epigenomes of at least 100 specific blood cell types.

Silencing mTOR expression using siRNA has not been studied previously in hematopoietic malignancies.

So mutations in the hematopoietic stem cells of healthy volunteers seemed to accumulate over time.

Modulating ECM assembly to alter tumor vascular barrier function Weilan Ye, Genentech Lymphangiogenesis and lymphatic endothelial barrier as targets in regenerative medicine Giorgia Jurisic, Novartis Wnt / beta - catenin signaling as a therapeutic target for blood - brain barrier repair in neurological disorders Dritan Agalliu, Columbia University Somatic mutations in hematopoietic cells contribute to cardiovascular disease: New mechanisms, new targets Kenneth Walsh, Boston University

Another modified peptide POL6326 is in phase II clinical trial in hematopoietic stem cell mobilization in multiple myeloma [128].

Rashim Pal Singh (Wielockx, TUD)-- «The Role of HIF - Prolyl hydroxylase 2 (PHD2) and Erythropoietin in the Hematopoietic System» (2013)

She is also an outstanding mentor for students and faculty who have an interest in hematopoietic cancers.

Tie2 expression and function has been established in hematopoietic stem cells13, macrophages14, muscle satellite cells15, neural cells16 and tumour cells17, 18.

Under normal physiological conditions, CXCR4 is mainly expressed in the hematopoietic and immune systems (Figure 1), where it carries out multiple functions.

Devine SM, Hoffman R. Role of mesenchymal stem cells in hematopoietic stem cell transplantation.

c - myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo.

Research Focus: Dr. Signer is a stem cell biologist whose trailblazing work on protein synthesis in hematopoietic stem cells opened the door to unchartered areas of cellular investigation.

CXCR4 is a G - protein - coupled receptor involved in a number of physiological processes in the hematopoietic and immune systems.

It is caused by mutations in the gene encoding the WAS protein (WASp) expressed in hematopoietic cells.

A research team led by cancer biologist Daniel Starczynowski, PhD, found that overexpression of a protein called TRAF6 in hematopoietic (blood) cells drives the onset of MDS.

«We used different groups of mice, in which either the oestrogen receptor or RANKL was inactivated in hematopoietic cells or in mesenchymal cells, to be able to identify the target cells of the hormone.

At the end of the project, the transduction efficiency of the newly made retroviral vectors was tested in hematopoietic cells, and here my «old» techniques came in handy.

Meanwhile, recent human studies indicate that aging is associated with an increase in somatic mutations in the hematopoietic system, which gives rise to blood cells; these mutations provide a competitive growth advantage to the mutant hematopoietic cells, allowing for their clonal expansion — a process that has been shown to be associated with a greater incidence of atherosclerosis, though specifically how remains unclear.

Not exact matches

Cesarean delivery and hematopoietic stem cell epigenetics in the newborn infant: implications for future health?

It's blood in a newborn baby's umbilical cord that's rich in a type of stem cell called hematopoietic progenitor cells (HPCs).

I spent the next decade completing rigorous basic science research training: completing a high school summer internship, attending the University of Maryland, Baltimore County as a Meyerhoff Scholar, and completing my Ph.D. in the Stanford immunology program, where my work focused on the mechanisms regulating hematopoietic and leukemic stem cells.

Hematopoietic stem cells, that form mature blood cells, require a very precise amount of protein to function — and defective regulation of protein production is common in certain types of aggressive human blood cancers.

«Transplanted hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»

The results strengthen support for the hypothesis that hematopoietic mutations play a causal role in atherosclerosis.

In this reconstituted schematic, hematopoietic stem cells (HSC) transplanted in a mouse model of Friedreich's ataxia differentiate into microglial cells (red) and transfer mitochondrial protein (green) to neurons (blue), preventing neurodegeneratioIn this reconstituted schematic, hematopoietic stem cells (HSC) transplanted in a mouse model of Friedreich's ataxia differentiate into microglial cells (red) and transfer mitochondrial protein (green) to neurons (blue), preventing neurodegeneratioin a mouse model of Friedreich's ataxia differentiate into microglial cells (red) and transfer mitochondrial protein (green) to neurons (blue), preventing neurodegeneration.

UTSW co-authors include: Co-lead author Maria Winter, a research associate; Dr. Luisella Spiga, a postdoctoral researcher; visiting fellow Lisa Büttner; graduate students Elizabeth Hughes and Caroline Gillis, all of Microbiology; Dr. Breck Duerkop, Instructor, Immunology; Cassie Behrendt, a research technician, Immunology; Dr. Lora Hooper, Professor and Chair of Immunology with appointments in Microbiology and in the Center for the Genetics of Host Defense, a HHMI Investigator and holder of the Jonathan W. Uhr, M.D. Distinguished Chair in Immunology, and the Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research, in Honor of Dr. Bill S. Vowell; Dr. Luis Sifuentes - Dominguez, Instructor of Pediatrics; Dr. Kayci Huff - Hardy, clinical fellow, Internal Medicine in the Division of Digestive and Liver Diseases; Dr. Andrew Koh, Associate Professor of Pediatrics and Microbiology and in the Harold C. Simmons Comprehensive Cancer Center as well as Director of Pediatric Hematopoietic Stem Cell Transplantation at Children's Health; and Dr. Ezra Burstein, Professor of Internal Medicine and Molecular Biology and Chief of the Division of Digestive and Liver Diseases.

When Busch turned on the marker in adult animals, it became visible that at least one third (approximately 5000 cells) of a mouse's hematopoietic stem cells produce differentiated progenitor cells.

«The ability to control autoimmunity by autologous HSCT [hematopoietic stem cell transplantation] has been demonstrated in other treatment - refractory autoimmune conditions, including neurologic diseases.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

Omer, Tzannou and their colleagues conducted a clinical trial to determine the safety and effectiveness of pre-prepared virus - specific cells to treat five viral infections simultaneously in patients who had received a hematopoietic stem cells transplant.

The findings were published in an article, «Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells,» in the August 11, 2016 issue of the journal Cell.

In addition to suppressing the mature blood cells battling against the infection, malfunctioning of this signaling system results in permanent damage to the body's blood producing cells — called hematopoietic stem cells — that are located in the bone marroIn addition to suppressing the mature blood cells battling against the infection, malfunctioning of this signaling system results in permanent damage to the body's blood producing cells — called hematopoietic stem cells — that are located in the bone marroin permanent damage to the body's blood producing cells — called hematopoietic stem cells — that are located in the bone marroin the bone marrow.

Hematopoietic stem cells — bone marrow - derived adult stem cells that give rise to the wide variety of specialized blood cells — come in two flavors: the reserve force sits quietly waiting to be called upon while the active arm continually proliferates spawning billions of blood cells every day.

The findings, published today in Nature, demonstrate that these myeloproliferative neoplasias only appear after damage to the microenvironment that sustains and controls the hematopoietic stem cells — the cells that produce the cells of the blood and the immune system.

«Active HSCs (hematopoietic stem cells) form the daily supply line that continually replenishes worn - out blood and immune cells while the reserve pool serves as a backup system that replaces damaged active HSCs and steps in during times of increased need,» explains Li.

Journal reference: JAMA, C - Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

«In normal conditions, the microenvironment is able to control the proliferation, differentiation and migration of the hematopoietic stem cell.

She then followed up with a closer look at role of the Igf2 signaling pathway in coaxing quiescent hematopoietic stem cells to start dividing and maturing into multi-lineage progenitors that ultimately give rise to specialized blood cells.

To gauge the effect off the loss of imprinting control on the maintenance of the quiescent hematopoietic stem cell pool, Venkatraman analyzed the numbers of quiescent, active and differentiated hematopoietic stem cells in mouse bone marrow.

Our blood is generated by blood - forming (hematopoietic) stem cells (HSCs) in the bone marrow.

In the case of blood stem cells (also called hematopoietic stem cells or HSCs), this can lead to blood cancers, a loss of blood cells and an impaired ability to fight disease.