Sentences with phrase «in human and mouse»

Meisler MH, Ottman KJ, and Escayg A. Identification of epilepsy genes in human and mouse.

The immunopurification (IP) of Argonaute (Ago), a central component of the RISC in the human and mouse, followed by microarray analyses (Ago IP / microarray method) makes it possible to isolate any Ago - associated miRNAs and mRNAs without relying on the mechanism of regulation (i.e. mRNA decay or translational suppression), or sequence conservation, enabling a comprehensive identification of the miRNA - target genes in an unbiased manner.

While there are only a few hundred ultraconserved sites in the human and mouse genomes, there are also approximately 100,000 other, less well - conserved enhancers.

It can efficiently introduce DNA into a cell to be incorporated into its genetic make - up, i.e. induce high gene expression level, especially in both human and mouse breast cancer cell lines, and mouse breast cancer model.

Furthermore, sgRNA targeting GPI anchor protein pathway genes induced loss of function mutations in human and mouse cell lines measured by FLAER labelling.

2017-08-21 - New publication An integrated expression atlas of miRNAs and their promoters in human and mouse.

In 1999, he was named an Alexander Hollaender Distinguished Fellow where he identified a novel apolipoprotein (ApoA5) involved in human and mouse triglyceride metabolism.

Reference: Norah M.E. Fogarty et al. «Genome editing of OCT4 reveals distinct mechanisms of lineage specification in human and mouse embryos.»

«What we found is that the majority of the gene expression patterns are very similar in human and mouse,» Yue said.

Oocyte activation ability correlates with head flatness and presence of perinuclear theca substance in human and mouse sperm.

They used a set of lineage - specific transposons in human and mouse to identify regions of DNA gain.

To identify false - positives and estimate the type 1 error rate, we used the genomic positions of a set of known lineage - specific repeat families in human and mouse, since lineage - specific repeat insertions should not overlap ancestral elements.

In a study published online in Genome Research, researchers devised a strategy for genome - wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse, and shedding light on mechanisms of regulation of microRNA gene expression.

-- 90 percent of genes associated with disease are identical in the human and the mouse, supporting the use of mice as model organisms.

He found that each of the probes fastened to hundreds of distinct proteins in human and mouse cells.

Our side by side analysis uncovers the dynamics of epigenetic programming occurring in germ cell development at single base resolution in human and mouse cells.»

Professor Wolf Reik, Head of the Epigenetics research programme, said: «Charting the different developmental timings in the early reprogramming events observed in the human and mouse - derived cells gives the first mechanistic insight into how these events are regulated which is tremendously exciting.

Once the vector is ready, the Baylor team wanted to be able to guide it to a certain part of the genome every time, so they turned to a technique called ΦC31, which was known to work in human and mouse cells.

The FANTOM project has drawn up a list of all the promoters in human and mouse genomes.

The research, conducted in human and mouse immune cells, appears online in the journal Proceedings of the National Academy of Sciences.

Yesterday's ruling effectively said that Feng Zhang's adoption of the technique in human and mouse cells was, in fact, a new and patentable invention rather than an «obvious» extension of Doudna's and Charpentier's work.

Infant calming responses during maternal carrying in humans and mice.

Infant Calming Responses during Maternal Carrying in Humans and Mice.

The study examined specific immune pathways known to be activated during flu infections in both humans and mice, which makes the findings relevant to children.

Since then, he and his colleagues have modified the sequences of influenza viruses to bind to a natural microRNA expressed in humans and mice, in essence developing a virus that's knocked down by the body's natural microRNA.

«Both in humans and mice there is a correlation between altered gut microbiota composition and inflammaging, but the link between the two remains to be proven in humans» concludes Fransen.

In humans and mice, the gene is associated with height, face development and other traits.

«We identified that the peculiar look of these naked lizards is due to the disruption of the ectodysplasin - A (EDA), a gene whose mutations in humans and mice are known to generate substantial abnormalities in the development of teeth, glands, nails and hairs», says Michel Milinkovitch.

The researchers published their views of nine cell types, including cancer cells in both humans and mice, in the December 18, 2014, issue of Cell.

After conducting studies in both humans and mice, the researchers said this new schizophrenia risk gene, called C4, appears to be involved in eliminating the connections between neurons — a process called «synaptic pruning,» which, in humans, happens naturally in the teen years.

Additional research will need to be done to determine whether plasticity in humans and mice is regulated in the same way.

Using a model of Parkinson's disease in which the toxin MPTP, made famous in book «The Case of the Frozen Addicts,» induces Parkinson's - like symptoms in humans and mice, Dr. Smeyne showed that mice infected with H1N1, even long after the initial infection, had more severe Parkinson's symptoms than those who had not been infected with the flu.

Galatzer - Levy analyzed data from large studies in humans and mice that involved «fear conditioning» and «fear extinction,» during which subjects receive a mild aversive stimulus when exposed to a sound or light, and «fear extinction learning,» during which conditioning is reversed by applying sound or light without the stimulus.

A total of 24 genes including a gene called Aipl1 — standing for aryl hydrocarbon receptor interacting protein like 1 — have been linked to LCA in humans and mice.

Body temperature differences of 1 °C to 3 °C found between the morning and the evening in humans and mice have therefore important implications.

University of Bonn researchers have discovered a new method to measure the activity of brown fat cells in humans and mice.

Our data in humans and mice show that adipocyte size is a strong predictor of the percentage of macrophages in adipose tissue (Figure 3e).

Mice lacking the organic cation transporter OCT1 provide molecular insights into how levels of thiamine (vitamin B1) and OCT1 influence metabolic traits observed in humans and mice.

A total of 24 genes including a gene called Aipl1 — standing for aryl hydrocarbon receptor interacting protein like 1 - have been linked to LCA in humans and mice.

MAIT cells migrate to the site of bacterial infection both in humans and mice.

To Wright, the signals in both humans and mice mean that there's more similarity between humans and animals than might meet the eye.

The genes in humans and mice are essentially the same genes — they were inherited from a common mammalian ancestor millions of years ago.

Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice.

His plans for research in his own lab involve «continuing to look at the mechanisms of T cell dysfunction in human and mice.

Studying cells from the stomach and pancreas in humans and mice, as well as mouse kidney and liver cells, and cells from more than 800 tumor and precancerous lesions in people, the researchers found when tissue is injured by infections or trauma, mature cells can revert back to a stem - cell state in which they divide repeatedly.

Mutations occurring in this gene cause polycystic kidney disease and type II diabetes both in human and mice

Dr. Berghout received her PhD in Biochemistry from McGill University in Montreal, QC where she researched the genetics of complex traits and susceptibility to infectious disease in humans and mouse models.

«We are encouraged in this regard by the strong similarities we found between klotho's effects in humans and mice in our earlier study.

Chong Wee Liew, Ph.D., lead author and a postdoctoral researcher in the Kulkarni lab, first examined the expression of the tribbles protein in pancreatic islets (which house beta cells and other hormone - producing cells) in both humans and mice.

By understanding multiple different components of fear memory formation and modulation in humans and mice, a number of novel, powerful, and targeted treatment and intervention approaches may become possible.