Sentences with phrase «in human asthma»

Considerably more research has been done by physicians on the underlying changes occurring in human asthma than veterinary research studies of cats with asthma.

In 2007, he was awarded a prestigious National Career Development Fellowship to undertake translational studies in the epigenetic regulation of the immune cell signaling molecules in human asthma under the mentorship of K. Mark Ansel, Ph.D., at UC San Francisco, where he was appointed adjunct assistant professor in the Department of Medicine in 2009.

Additionally, we clarified the role of iNKT cells in human asthma by carefully enumerating cell numbers in airway samples from asthma and COPD patients.

In 2008, he obtained his Ph.D. from the University of Southampton, United Kingdom, where he studied the mechanisms of accumulation and activation of T cells in human asthma.

We show here that acidic mammalian chitinase (AMCase) is induced via a T helper - 2 (Th2)-- specific, interleukin - 13 (IL - 13)-- mediated pathway in epithelial cells and macrophages in an aeroallergen asthma model and expressed in exaggerated quantities in human asthma.

Not exact matches

The 36 - year - old told the Times that his own asthma and food allergies triggered his interest in the ability of the human body's immune system to fight diseases.

Working with human immune cells in the laboratory, Johns Hopkins researchers report they have identified a critical cellular «off» switch for the inflammatory immune response that contributes to lung - constricting asthma attacks.

The research team then infected specially bred mice carrying G protein - coupled receptors and those without the receptor with an influenza virus — which is known to trigger asthma attacks in humans.

It remains unclear whether a similar pathway operates in humans, but the results «complement what we see in epidemiology», says Erika Von Mutius, head of the Asthma and Allergy Department at Munich University Children's Hospital in Germany.

Dupilumab, a fully human monoclonal antibody discovered by Regeneron Pharmaceuticals and being developed by Regeneron and Sanofi, thwarts activation of the Th2 immune response implicated in asthma by blocking two cytokines, interleukin - 4 and interleukin - 13.

A human enzyme that can degrade the chitin of insect exoskeletons also regulates allergic inflammation in asthma, reinforcing the similarities between immune responses to parasitic and allergic stimuli.

When the team turned to human lung cells, they found that A20 was also less active in adults with asthma.

The chemicals, considered hormone disruptors, have been linked to health effects in animal tests and some human studies, including altered male genitalia, attention and learning problems and asthma.

In a new research report published in the June 2014 issue of the Journal of Leukocyte Biology, researchers show that in individuals with asthma, statins significantly reduce the in vitro inflammatory response of human monocytes to rhinovirus (RV), the cause of the common colIn a new research report published in the June 2014 issue of the Journal of Leukocyte Biology, researchers show that in individuals with asthma, statins significantly reduce the in vitro inflammatory response of human monocytes to rhinovirus (RV), the cause of the common colin the June 2014 issue of the Journal of Leukocyte Biology, researchers show that in individuals with asthma, statins significantly reduce the in vitro inflammatory response of human monocytes to rhinovirus (RV), the cause of the common colin individuals with asthma, statins significantly reduce the in vitro inflammatory response of human monocytes to rhinovirus (RV), the cause of the common colin vitro inflammatory response of human monocytes to rhinovirus (RV), the cause of the common cold.

This study, for the first time, proved that these cells continually produce this protein in humans with asthma,» states O'Byrne.

Because mice with intact immune systems are resistant to S. stercoralis infection, the researchers began with an immunocompromised strain of mice, and then exposed some to a synthetic steroid called methylprednisolone (MPA) that is commonly used to treat asthma in humans.

Ground - level ozone, which is distinct from the ozone in the upper atmosphere that protects the planet from ultraviolet radiation, is harmful to human health, exacerbating asthma attacks and causing difficulty breathing.

If this type of therapy proves safe in humans, a syringe full of oxygen microbubbles could help avert brain damage and death for the victims of cardiac arrest, asthma attacks, strokes, and injuries to the lungs, airway, or face.

In humans, Newcomb and her colleagues measured the number of group 2 innate lymphoid cells circulating in the blood of adults with moderate to severe asthmIn humans, Newcomb and her colleagues measured the number of group 2 innate lymphoid cells circulating in the blood of adults with moderate to severe asthmin the blood of adults with moderate to severe asthma.

Asthma is a disease of the human respiratory system in which the airways narrow, often in response to a «trigger» such as exposure to an allergen, cold air, exercise, or emotional stress.

To examine the allergy - asthma link, molecular geneticist Tim Howard and colleagues at the Center for Human Genomics at Wake Forest University in Winston - Salem, North Carolina, took a close look at two genes associated with asthma in previous studies.

The research team then tested RMC - 1 in cultured human airway epithelial cells and mouse models of asthma (via injection into the animals» peritoneal cavities).

He thinks targeting nerve cells could be a feasible therapeutic approach for asthma in humans.

«Recent increases in chronic diseases like childhood asthma and autism can not be due to major shifts in the human gene pool,» says physician and geneticist Francis Collins, former director of the National Human Genome Research Instihuman gene pool,» says physician and geneticist Francis Collins, former director of the National Human Genome Research InstiHuman Genome Research Institute.

In humans, the incidence or severity of many diseases, such as asthma, myocardial infarction, stroke, and depression exhibit diurnal variation.

OVER THE PAST FEW YEARS, researchers have come to realize the importance of the human microbiome — the roughly 100 trillion microorganisms that live in our gut — in everything from health and digestion to asthma and brain development.

Dysfunctional microbiomes are associated with issues including human chronic diseases such as obesity, diabetes, and asthma; local ecological disruptions such as the hypoxic zone in the Gulf of Mexico; and reductions in agricultural productivity.

Emulate's Lung - Chip Demonstrates New Capabilities to Predict Human Lung Inflammation and Drug Responses in Asthma and COPD

This micro-engineered Airway Lung - Chip recapitulates key features of viral - induced human asthma exacerbation and provides unique opportunities to explore the complex mechanisms underlying asthma exacerbation in a human - relevant model.

Infection with human rhinovirus, the most common cause of asthma exacerbation in adults and children, was restricted to ciliated cells and resulted in ciliated cell apical sloughing and goblet cell hyperplasia, replicating hallmarks of cytopathology observed in vivo.

For many human diseases, large - scale genomic studies have identified common genetic variants that occur more frequently in people with cardiovascular, autoimmune, inflammatory and infectious diseases, diabetes and asthma than in those without these diseases.

«In humans MAIT cells are unique in that they are borne to make gamma interferon, which could help skew the immune system toward an asthma - protective Th1 immune responsIn humans MAIT cells are unique in that they are borne to make gamma interferon, which could help skew the immune system toward an asthma - protective Th1 immune responsin that they are borne to make gamma interferon, which could help skew the immune system toward an asthma - protective Th1 immune response.

Human respiratory microbiome Review: Lung epithelium: barrier immunity to inhaled fungi and driver of fungal - associated allergic asthma — Darin L Wiesner — Current Opinion in Microbiology

Dr. Nobrega has modeled the impact of mutations implicated in various human diseases, such as congenital heart defects, heart failure, cancer, type 2 diabetes, obesity, and asthma.

A paper describing the discovery, entitled «A major susceptibility gene for asthma maps to chromosome 14q24,» has been published in the online edition of the American Journal of Human Genetics at www.ajhg.org.

IMAGE: Human airways already demonstrate gender - based differences in DNA methylation signatures at birth, providing an early hint of which infants may be predisposed to develop respiratory disorders like asthma later in...

WASHINGTON - Human airways already demonstrate gender - based differences in DNA methylation signatures at birth, providing an early hint of which infants may be predisposed to develop respiratory disorders like asthma later in life, a research team reports in a paper published online April 3, 2018, in Scientific Reports.

The World Health Organization and United Nations this year concluded: «Exposure to E.D.C.s during fetal development and puberty plays a role in the increased incidences of reproductive diseases, endocrine - related cancers, behavioral and learning problems, including A.D.H.D., infections, asthma, and perhaps obesity and diabetes in humans.»

Bloodroot has been used for emphysema, laryngitis, colds, sinus infections, bronchitis and asthma It has been used as a remedy for skin cancers in humans and animals and relieves skin ulcers, eczema, nasal polyps, ringworm, fungal growths and sores.

There is INSUFFICIENT EVIDENCE [1,4,5] about the effectiveness of lycopene supplements in the prevention or treatment of age - related macular degeneration (AMD), asthma, atherosclerosis, benign prostate hyperplasia, cancer (brain, breast, cervical, lung, ovarian, pancreatic, prostate), cataracts, coronary heart disease, diabetes type 2, gingivitis, high blood pressure, hot flashes in menopausal women, human papilloma virus (HPV) infection, inflammation, infertility, kidney disease, mouth sores (oral leukoplakia), or as an anticoagulant (blood thinner) or antioxidant or as sun protection.

Similar to asthma in humans, these airways can become inflamed and make it difficult for your cat to breathe.

But what causes human discomfort in the form of inflammation of the nose, asthma attacks, rashes and wheezing isn't the fault of the innocent dog.

Sometimes elderly people need to live in nursing homes that don't allow cats, human ailments such as asthma or allergies make it difficult to care for a cat, or the previous owners simply couldn't afford to care for a pet.

Natural litters are virtually dust - free and don't contain any chemical odor - masking agents and fragrances that are often found in clay products and believed to trigger or irritate asthma and other respiratory issues in both cats and humans.

Feline Asthma shares some characteristics with asthma in humans, including symAsthma shares some characteristics with asthma in humans, including symasthma in humans, including symptoms.

Feline asthma shares many characteristics with asthma in humans.

Treatment As in humans, asthma is a condition that is treated but not truly cured.

For example, in humans we know that while actual symptoms of asthma occur in episodes, the airways of the lung are diseased all the time.

Corticosteroid medications and bronchodilators used to treat asthma in humans are also helpful in pets, although the dosages are much lower.

Feline asthma is similar to human asthma, in that it is a chronic inflammation of the airways inside the lungs.