Additionally, cells expressing MSC markers were found to localize to blood vessel walls
in human bone marrow and dental pulp.
Clough BH, Zeitouni S, Krause U, et al., Rapid Osteogenic Enhancement of Stem Cells
in Human Bone Marrow Using a Glycogen ‐ Synthease ‐ Kinase ‐ 3 ‐ Beta Inhibitor Improves Osteogenic Efficacy In Vitro and In Vivo.
Not exact matches
While scientists have previously had success
in 3D printing a range of
human stem cell cultures developed from
bone marrow or skin cells, a team from Scotland's Heriot - Watt University claims to be the first to print the more delicate, yet more flexible,
human embryonic stem cells (hESCs).
Then, to boost the number of cells, which is another hurdle
in tissue engineering, the researchers mixed the chondrocytes with
human mesenchymal stem cells from
bone marrow.
Adding stem cells from
human bone marrow to a broken diabetic
bone enhances the repair process, increasing the strength of the newly formed
bone, according to a laboratory - based study presented at the European Congress of Endocrinology
in Dublin.
The researchers added
human bone marrow stem cells from a non-diabetic donor to a
bone fracture
in laboratory pre-clinical studies.
Dr. Zubair, medical and scientific director of the Cell Therapy Laboratory at Mayo Clinic
in Florida, says the experiment will be the first one Mayo Clinic has conducted
in space and the first to use these
human stem cells, which are found
in bone marrow.
In humans, a comparison of bone marrow from 14 normal bone marrow donors, 35 multiple myeloma patients and 11 patients with a noncancerous condition called monoclonal gammopathy of undetermined significance (MGUS) showed that Runx2 levels were significantly higher in the multiple myeloma cell
In humans, a comparison of
bone marrow from 14 normal
bone marrow donors, 35 multiple myeloma patients and 11 patients with a noncancerous condition called monoclonal gammopathy of undetermined significance (MGUS) showed that Runx2 levels were significantly higher
in the multiple myeloma cell
in the multiple myeloma cells.
He points to recent success of partially matched
bone marrow transplants
in humans, shown to be equally as effective as fully matched transplants.
In a first step towards creating artificial sperm cells, researchers have turned
human bone marrow tissue into primitive sperm cells.
Once Katlyn arrived
in May 2007, Candotti and his team removed stem cells from her
bone marrow and exposed them to the engineered retrovirus, creating a
human - virus hybrid.
In experiments in mice and human cells, researchers found that blocking CXCR4 — a so - called homing receptor protein molecule that helps T cells mature and attracts blood cells to the bone marrow — halted disease progression in bone marrow and spleen tissue within two week
In experiments
in mice and human cells, researchers found that blocking CXCR4 — a so - called homing receptor protein molecule that helps T cells mature and attracts blood cells to the bone marrow — halted disease progression in bone marrow and spleen tissue within two week
in mice and
human cells, researchers found that blocking CXCR4 — a so - called homing receptor protein molecule that helps T cells mature and attracts blood cells to the
bone marrow — halted disease progression
in bone marrow and spleen tissue within two week
in bone marrow and spleen tissue within two weeks.
• A Columbia University team headed by Silviu Itescu used
human bone marrow to build new blood vessels
in the hearts of rats.
The study developed a new
in vitro system made from
bone marrow stem cells and studied what would happen if its ambient temperature fell below 37 °C (the natural temperature of the
human body).
• Piero Anversa at New York Medical College
in Valhalla, New York, and Donald Orlic at the National
Human Genome Research Institute
in Bethesda, Maryland, used mouse
bone marrow to repair damaged mouse hearts.
The use of
bone marrow - derived stem cells is well established
in the treatment of
human cancer patients, and veterinary applications for
bone marrow - and adipose - derived stem cells are being evaluated.
Prior research with cultured tissue had shown that a mix of chemicals could change
bone marrow stem cells from mice to those resembling brain cells, but when a team led by neurologist Lorraine Iacovitti of Thomas Jefferson University
in Philadelphia tried the same brew on
human cells, the number altered was modest.
BMT was effective
in mice, but
in humans resulted
in death before the new
bone marrow grew and expanded (called engraftment)
in treated patients.
She ultimately chose to study leukemia patients» immune responses to
bone marrow transplants, an area conducive to translational research
in part because the work involves treating patients with
human cells, which can be prepared at academic health centers.
Future research Because there are few salivary gland stem cells
in the
human mouth, the scientists plan to continue using rat salivary glands to refine the process, but eventually hope to use stem cells derived from
human bone marrow or umbilical cord blood to regenerate salivary glands for
humans.
Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on
human T reg cells, suggesting that the approach could also prevent GvHD
in leukemia and lymphoma patients after
bone marrow or hematopoietic stem cell transplants.
The first
human bone marrow transplant was performed
in 1956 by E. Donnall Thomas.
Pathologist Hinh Ly's research has made a connection between genetic defects
in telomere maintenance and
bone marrow failure syndrome
in human patients.
Comparison of
human adult stem cells from adipose tissue and
bone marrow in the treatment of experimental autoimmune encephalomyelitis.
Human immunodeficiency virus (HIV) can infect
bone marrow cells — including, possibly, hematopoietic stem cells, according to a study published online today (March 7)
in Nature Medicine.
In close collaboration with universities and physicians world - wide, our comprehensive investigational stem cell treatments employ well - targeted combinations of allogeneic
human umbilical cord stem cells, autologous
bone marrow stem cells, and autologous adipose stem cells for the diseases listed below.
In separate experiments reported in Nature — one with mice, the other transplanting human stem cells into mouse bone marrow — researchers demonstrated techniques with the potential to produce all types of blood cell
In separate experiments reported
in Nature — one with mice, the other transplanting human stem cells into mouse bone marrow — researchers demonstrated techniques with the potential to produce all types of blood cell
in Nature — one with mice, the other transplanting
human stem cells into mouse
bone marrow — researchers demonstrated techniques with the potential to produce all types of blood cells.
Cytokinesis failure occurs
in Fanconi anemia pathway — deficient murine and
human bone marrow hematopoietic cells.
Osteogenic induction of
human bone marrow - derived mesenchymal progenitor cells
in novel synthetic polymer - hydrogel matrices.
Blood formation
in the
human embryo begins
in the liver at about week 5 and at week 12
in the spleen, red
bone marrow, and thymus.
Quantification of lipids
in human lower limbs using yellow
bone marrow as the internal reference: gender - related effects
Notch signaling enhances osteogenic differentiation while inhibiting adipogenesis
in primary
human bone marrow stromal cells.
The study assessed safety and efficacy of intracoronary autologous transplantation of
bone marrow - derived
human MSCs
in patients with acute myocardial infarction.
By studying how the rat body accepts or rejects transplanted pancreas, skin, heart, kidney, or
bone marrow, scientists have helped medical doctors successfully perform life - saving transplants
in human adults and children.
This groundbreaking work influenced many scientists investigating
bone marrow transplant for
humans, including the winner of the 1990 Nobel Prize
in Physiology or Medicine.
Patients receive one of two types of stem cell - based transplants: autologous,
in which a patient donates and receives back his / her own stem cells; or allogeneic,
in which
bone marrow - derived stem cells come from a related or unrelated donor whose
human leukocyte antigens (HLA) are genetically matched with those of a patient.
In the recent study, the researchers used CRISPR snipped out the sickle cell mutation from donated
human bone marrow cells, and replaced it with non-mutated DNA.
If successful, this may lead to therapies for
humans in which a patient's stem cells will be reverted into iPSCs, then genetically repaired and transplanted back into the
bone marrow of the same patient.
Human embryonic stem cells grown at the University of Wisconsin - Madison randomly changed into cell types found
in the A) gut B) brain C)
bone marrow D) cartilage E) muscle F) kidney Scientists haven't learned to control the development.
A quantitative assessment of the content of hematopoietic stem cells
in mouse and
human endosteal -
bone marrow: a simple and rapid method for the isolation of mouse central
bone marrow.
Another is to monitor the effects of transplanting telomerase - deficient but ex vivo telomere - extended
bone marrow into late - generation, TMM - disabled mice, so as to be certain that the niche of such animals (or, by implication, aging
humans) will support the homing, engraftment, and initial development and differentiation of such cells; the necessary research is underway now thanks to a SENS Foundation grant to Dr. Zhenyu Ju of the Institute of Laboratory Animal Sciences and Max - Planck - Partner - Group on Stem Cell Aging
in the Chinese Academy of Medical Sciences, and research partner of prominent telomere biologist Dr. K. Lenhard Rudolph.
Rapamycin is a drug currently approved for immunosuppression during preparatory and maintenance regimens for organ and
bone marrow transplant
in human patients.
Well known for causing idiosyncratic (non-dose-dependent) anemia
in people and dose - dependent
bone marrow suppression
in animals, its use
in both
human and veterinary medicine is increasing because of resistance to other antimicrobial drugs.
Bone marrow transplants for dogs is a relatively new procedure that involves the use of Leukophoresis machines — the same equipment used
in human medicine — that are designed to harvest healthy stem cells from the peripheral blood.