Ab7291 staining alpha tubulin
in human breast cancer cell line by ICC / IF (Immunocytochemistry / Immunofluorescence).
He is researching the functions and properties of human sulfotransferase (EST) enzymes
in human breast cancer cell lines.
The analysis of doxorubicin resistance
in human breast cancer cells using antibody microarrays.
Multiple effects of a novel epothilone analog on cellular processes and signaling pathways regulated by Rac1 GTPase
in the human breast cancer cells.
TGF -[beta] induces formation of F - actin cores and matrix degradation
in human breast cancer cells via distinct signaling pathways.
Zhu Q, Jin L, Casero RA, Davidson NE, Huang Y. Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth
in human breast cancer cells.
«We have found that the same genes responsible for tamoxifen resistance in our animals are also turned off
in human breast cancer cells that do not respond to the drug,» she says «Because these genes were epigenetically silenced — meaning they were not irreversibly altered, just switched off — it was possible to turn them back on.
Using RNA interference (RNAi), first author Richard Possemato targeted these genes
in human breast cancer cells implanted in mice.
And we confirmed that the growth of the tumors formed by the human BCSCs transfected with the anti-miR-142-expressing lentivirus was significantly slower than those of the control tumors formed by the control lentivirus transfected BCSCs (Major points raised by the editors and the reviewers # 3) These data suggest that the regulation of APC and the Wnt signaling is at least one of the important pathways targeted by miR - 142
in human breast cancer cells and BCSCs.
1) The results of the inhibition of miR -142-3p in the human breast cancer xenograft cells and the Wnt signaling pathway inhibition
in human breast cancer cells have confirmed that our finding that miR - 142 targets APC, activates the Wnt signaling pathway and upregulates miR - 150 is applicable to human breast cancers.
Scientists have found that sulforaphane causes apoptosis — or programmed suicide —
in human breast cancer cells.
Not exact matches
In November 2010 Japanese researchers announced online in Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and breast cancer cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cell
In November 2010 Japanese researchers announced online
in Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and breast cancer cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cell
in Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and
breast cancer cells respond to
cancer drugs, and
in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cell
in February 2010 scientists publishing
in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cell
in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the
human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe
in cultured cell
in cultured
cells.
Recent collaborative work between UCR and Cedars - Sinai Medical Center
in Los Angeles demonstrated that
in animal models of
human breast cancer, mice treated with 123B9 that was conjugated with paclitaxel had significantly fewer circulating
cancer cells in the blood compared to mice that were not treated or even treated with paclitaxel alone.
In their latest study, they tested compounds against
cells from nine different types of
human cancer, including common types affecting blood, colon,
breast, prostate, ovaries, kidneys, and lungs.
Bloch's colleagues at the National Institute of Environmental Health Sciences tested the oils
in gene expression studies on lab - grown
human breast cancer cells and found that they could mimic estrogens, the primary female sex hormones, and inhibit androgens, the primary male sex hormones.
Lab testing showed that the plant - made virus particles, which naturally bind to receptors on
cancer cells, were taken
in by
human breast cancer cells.
Using this biosensor
in highly invasive
breast cancer cells taken from rodents and
humans, the Einstein team discovered that when an individual invadopodium forms and is actively degrading the ECM, its Rac1 levels are low; on the other hand, elevated Rac1 levels coincide with the invadopodium's disappearance.
If further research confirms the findings
in human cells, limiting the amount of asparagine
cancer patients ingest could be a potential strategy to augment existing therapies and to prevent the spread of
breast cancer, Knott added.
Pre-clinical studies have shown it to be effective
in eliminating a number of different kinds of
cancers cells, including
cancer stem
cells from
human breast cancer patient biopsies.
The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model
human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part
in the process of the division of
cancer cells, and therefore inhibited the proliferation of the
cells.
Moreover, epalrestat, a drug that inhibits AKR1B1 and is approved
in Japan to treat peripheral neuropathies associated with diabetes, was similarly able to block the growth and metastasis of
human basal - like
breast cancer cells.
Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads)
in the lungs of mice injected with
human basal - like
breast cancer cells.
Beyond lung
cancer, TiY is able to target TICs
in 28 types of
human cell lines derived from the central nervous system, melanoma,
breast, renal, ovarian, colon, and prostate
cancer.
Working with
human breast cancer cells and mouse models of
breast cancer, scientists identified a new protein that plays a key role
in reprogramming
cancer cells to migrate and invade other organs.
Working with
human breast cancer cells and mice, scientists at The Johns Hopkins University say new experiments explain how certain
cancer stem
cells thrive
in low oxygen conditions.
«There are still many questions left to answer but we now know that oxygen poor environments, like those often found
in advanced
human breast cancers serve as nurseries for the birth of
cancer stem cells,» says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine and a member of the Johns Hopkins Kimmel Cancer C
cancer stem
cells,» says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine and a member of the Johns Hopkins Kimmel
Cancer C
Cancer Center.
Through these effects, the PERY peptide reduced the proliferation of several (but not all)
cancer cell lines
in culture and inhibited the growth of a
human breast cancer xenograft
in mice.
In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to sprea
In earlier studies involving animal models and
human cancer cell lines, researchers found that
breast cancer spreads when three specific
cells are
in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to sprea
in direct contact: an endothelial
cell (a type of
cell that lines the blood vessels), a perivascular macrophage (a type of immune
cell found near blood vessels), and a tumor
cell that produces high levels of Mena, a protein that enhances a
cancer cell's ability to spread.
Lead author Moustafa Abdalla writes: «Almost all genomic studies of
breast cancer have focused on well - established tumours because it is technically challenging to study the earliest mutational events occurring
in human breast epithelial
cells.»
One of these, UJ3, is as effective as the industry - standard drug Cisplatin
in killing
cancer cells in laboratory tests done on
human esophageal
cancer,
breast cancer and melanoma.
In tumors formed by
human breast cancer cells, DNA damage (brown staining) is increased by simultaneous Olaparib treatment and PGAM1 suppression (right) when compared to either Olaparib treatment (left) or PGAM1 suppression (center) alone.
In this study, the researchers tested the effects of Olaparib on the tumors formed by
human breast cancer cells injected into mice.
Their study, published
in the ACS journal Chemical Research
in Toxicology, found that triclosan, as well as another commercial substance called octylphenol, promoted the growth of
human breast cancer cells in lab dishes and
breast cancer tumors
in mice.
In tests on human breast cancer cells and in special immunodeficient mice with tissue grafts, the scientists found that both agents interfered with genes involved with breast cancer cell growth, resulting in more cancer cell
In tests on
human breast cancer cells and
in special immunodeficient mice with tissue grafts, the scientists found that both agents interfered with genes involved with breast cancer cell growth, resulting in more cancer cell
in special immunodeficient mice with tissue grafts, the scientists found that both agents interfered with genes involved with
breast cancer cell growth, resulting
in more cancer cell
in more
cancer cells.
In the lab, the scientific team used an approach that combined functional RNAi analysis with gene expression analysis in breast cancer - derived cell lines and in human breast cancers replicated in mic
In the lab, the scientific team used an approach that combined functional RNAi analysis with gene expression analysis
in breast cancer - derived cell lines and in human breast cancers replicated in mic
in breast cancer - derived
cell lines and
in human breast cancers replicated in mic
in human breast cancers replicated
in mic
in mice.
«If further studies validate that these processes are critical
in human breast cancers,» Koshy notes, «the possibility exists that agents that favorably modify the biophysical properties of the extracellular matrix, or that target the receptors and signaling molecules associated with how
cells sense this matrix, could be used as a new avenue for the prevention or treatment of
breast cancers.»
However, scientists at SFU, the University of British Columbia and the B.C.
Cancer Agency have discovered that many non-coding RNAs are perturbed
in cancerous
human cells, including
breast and lung,
in a specific way.
Singletary added sulforaphane, a chemical
in broccoli, kale, brussels sprouts, and other cruciferous vegetables, to cultures of
human breast cancer cells.
Their preliminary findings indicate that MUS81 - induced movement of DNA to the cytosol also occurs
in human cancer cells, including prostate
cancer,
breast cancer, colorectal
cancer, uterine
cancer, leukemia, and melanoma
cells.
Previous evidence for a
breast cancer link has been mixed — one study found increased risk
in women exposed before age 14, whereas others found no association — but
in a lab dish, DDT has been shown to activate the HER2 gene
in human breast cells, which is expressed
in some
breast cancers.
After confirming
in mouse models that
cells from HER2 - positive
breast cancers became resistant to anti-HER2 treatment when implanted into the brain but not into other tissues, the investigators found that HER3 is overexpressed
in brain metastases of HER2 - positive
breast cancers from both mice and
human patients.
Now, University of Pennsylvania researchers have revealed how a reduction
in mitochondrial DNA content leads
human breast cancer cells to take on aggressive, metastatic properties.
The ability of the ITAM sequence to make
cells cancerous represents a potential new trigger for
breast cancer in humans, say the researchers, and gives further credence to the idea that viruses can cause
human breast cancer.
The researchers inserted between 10,000 and 40,000 of these small RNAs at once into
breast cancer, colon
cancer, and normal
human cells in the lab.
Recent studies with
human breast cancer cell lines have also shown that Shp2 mediates survival signals
in cancer cells.
Additionally, overexpression of POSTN
in human mammary epithelial and
breast cancer cells resulted
in enhanced tumor growth and metastasis (Wang et al., 2013), which is similar to a colon
cancer cell model where overexpression of POSTN resulted
in an increase
in the number and size of liver metastases (Bao et al., 2004).
In the test tube, the nanogenerators killed leukaemia, lymphoma,
breast, ovarian, neuroblastoma, and prostate
human cancer cells.
Regulation of the inflammatory profile of stromal
cells in human breast cancer: prominent roles for TNF - a and the NF -?
The example shown reveals that these estrogen agonists show the strongest connectivity to each other
in MCF7, a
human breast cancer cell line that expresses the estrogen receptor.
Mutations
in the gene increase rat susceptibility to mammary
cancer and FRY reduced the growth of highly aggressive
human breast cancer cells.