Sentences with phrase «in human breast tumors»

The technology has been demonstrated in animal models and also in human breast tumors.

They identified an alkylphenol leaching from the plastic as the culprit, having «estrogen - like properties when tested in the human breast tumor cells.»

Not exact matches

The researchers «deserve a lot of credit» for testing the approach in the mice that spontaneously develop breast tumors, he says, which more closely mimic how cancer arises in humans.

Oncologists William Hahn, Robert Weinberg, and colleagues at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, mutated the gene for one part of the enzyme and inserted it into cultured human cells from colon, ovary, and breast tumors.

Researchers have isolated exosomes from tumors and from blood of patients with breast cancer, and from blood of mice with human tumors grown after breast implantation in mice, called ortoxenogratfs.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

«We knew ZMYND11 was a candidate tumor - suppressor because it's down - regulated in a number of human cancers, including breast cancer,» Shi said.

Aiding their new research, Semenza says, was the knowledge that whereas the air we breathe is 21 percent oxygen, oxygen levels average around 9 percent in healthy human breast tissue but only 1.4 percent in breast tumors.

Horvath and Tell's research is the first reported study to compare breast cancer subtypes and gene expression patterns associated with STAT3 in the tumors of human patients.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spreaIn earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spreain direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

The title of the paper is «Bioinformatic analysis reveals a pattern of STAT3 - associated gene expression specific to basal - like breast cancers in human tumors.»

In tumors formed by human breast cancer cells, DNA damage (brown staining) is increased by simultaneous Olaparib treatment and PGAM1 suppression (right) when compared to either Olaparib treatment (left) or PGAM1 suppression (center) alone.

In this study, the researchers tested the effects of Olaparib on the tumors formed by human breast cancer cells injected into mice.

Their study, published in the ACS journal Chemical Research in Toxicology, found that triclosan, as well as another commercial substance called octylphenol, promoted the growth of human breast cancer cells in lab dishes and breast cancer tumors in mice.

Human breast tumors transplanted into mice are excellent models of metastatic cancer and are providing insights into how to attack breast cancers that no longer respond to the drugs used to treat them, according to research from Washington University School of Medicine in St. Louis.

Using cultured cells derived from human tumors of the breast and prostate gland, they confirmed that the IL6R / STAT3 / miR -34 a feedback loop is also activated in other tumor types.

The researchers grafted breast or lung tumors in mice, allowed the tumors to grow to small size and removed these tumors surgically — essentially mimicking the situation in a human tumor patient in which the tumor is surgically removed as soon as possible after diagnosis.

As a next step, Guha, Avadhani and colleagues plan to extend this study to in vivo mouse models and will also investigate these mechanisms in tumor samples from human breast cancer patients.

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

Additionally, overexpression of POSTN in human mammary epithelial and breast cancer cells resulted in enhanced tumor growth and metastasis (Wang et al., 2013), which is similar to a colon cancer cell model where overexpression of POSTN resulted in an increase in the number and size of liver metastases (Bao et al., 2004).

Further research uncovered a broad spectrum of cell surface stem cell markers (e.g., CD133, CD44, and CD24) that allow the identification of CSCs in human solid tumors, including brain, breast, prostate, pancreas, liver, ovary, skin, colon cancers, and melanoma (3 - 6)(Figure 1 based on 7).

Now, in Stem Cells Translation Medicine, the group of Shu Wang at the National University of Singapore describe the derivation of EPCs from human iPSCs, their therapeutic modification, and their ability to inhibit tumor growth in a mouse breast cancer model [4].

Unlike previous MRI studies of tumors in mice, the researchers were able to detect very small naturally occurring cancers, which were excellent models for human breast cancer; the tumors the mice developed were «realistic models of the most frequently detected human cancers,» the authors wrote.

The researchers then injected AAV2 into human breast cancer cell line - derived tumors in mice without functioning immune systems.

It has been reported that human breast CSCs and normal human mammary stem / progenitor cells showed decreased expression of miR200c and other miR200 members and that restoring miR200c in breast CSCs inhibits their ability to expand clonally and form tumors in vivo [38].

Rudensky's team compared Tregs in normal human breast tissues with those found in untreated breast tumors, and found that Tregs in tumors were capable of more potent and aggressive immunosuppressive action.

[i] Gutterman JU, Blumenschein GR, Alexanian R, Yap HY, Buzdar AU, Cabanillas F, Hortobagyi GN, Hersh EM, Rasmussen SL, Harmon M, Kramer M, Pestka S. Leukocyte interferon - induced tumor regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma.

Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous human tumor cell lines and xenograft models (including human breast, prostate, and lung carcinoma) at clinically achievable concentrations.

: This study evaluated the effects of an antagonistic analog of growth hormone - releasing hormone, MIA - 602, on tumor growth, response to doxorubicin, expression of drug resistance genes, and efflux pump function in human triple negative breast cancers.

Introduction: This study evaluated the effects of an antagonistic analog of growth hormone - releasing hormone, MIA - 602, on tumor growth, response to doxorubicin, expression of drug resistance genes, and efflux pump function in human triple negative breast cancers.

We also demonstrate that immunoglobulin - secreting NSCs exhibit preferential tropism to tumor cells in vivo, and can deliver antibodies to human breast cancer xenografts in mice.

Dr. Mack's research has focused primarily on the use of novel antitumor agents in human estrogen receptor negative breast tumor cells, and more recently, on the use of bioflavonoids in the regulation of estrogen receptor positive (ER +) and estrogen receptor negative (ER --RRB- breast tumor cell proliferation.

These kind of mice are an extraordinary resource for modeling human disease; for instance, research has found that mice that are genetically mutated to carry the BRCA1 gene (a human breast cancer gene) behave more similarly to human cancer patients than those mice who have had a tumor physically transplanted in.

Last year, Mandriota and collaborators demonstrated that in a cancer mouse model, concentrations of aluminum in the amount of those measured in the human breast are able to transform cultured mammary epithelial cells, allowing them to form tumors and to metastasize.

And we confirmed that the growth of the tumors formed by the human BCSCs transfected with the anti-miR-142-expressing lentivirus was significantly slower than those of the control tumors formed by the control lentivirus transfected BCSCs (Major points raised by the editors and the reviewers # 3) These data suggest that the regulation of APC and the Wnt signaling is at least one of the important pathways targeted by miR - 142 in human breast cancer cells and BCSCs.

Considering that miR - 142 is highly expressed in human BCSCs, but weakly expressed or undetectable in the stem / progenitor population of the mammary epithelial cells, our result suggest that the upregulation of miR - 142 and its enhancement of the miR - 150 expression seem to be especially relevant in the breast tumor progression in vivo.

The most frequent tumors in human — cancer of the colon, breast, lung, and prostate — all involve mutations in tumor suppressor genes.

These molecular subtypes have recently been confirmed in a comprehensive characterization of human breast tumors at the genomic, epigenetic, transcriptomic, and proteomic levels (Cancer Genome Atlas Network, 2012).

Many women are «triple negative» No one yet knows precisely why, but African - American women are roughly twice as likely as white women to have triple - negative breast cancer — so called because tumor cells in this particularly aggressive form of the disease test negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER - 2).

We know that the lemony aura of limonene is more than just a scent, as it can be found in our blood after exposure.8 Furthermore, several anticancer cellular pathways appear to be affected by the terpene limonene, leading some to suggest it has anticancer, or chemopreventative, benefits.9 While feeding it to rats in studies has revealed some efficacy against breast tumors, 10 we have a ways to go before we can make such bold claims in humans.

Studies of Gluts in human tumors have shown a significant increase in the abundance of Glut1 and Glut3 mRNA in cancers of the esophagus, colon, and pancreas, overexpression of Glut1 and Glut3 mRNA and Glut1 protein expression in head and neck tumors and Glut1 protein overexpression in breast and renal cell carcinomas

As a result, breast cancer cell growth is blocked One study in mice concluded that flaxseed inhibited the growth of human estrogen - dependent breast cancer, and strengthened the tumor - inhibitory effect of tamoxifen.

According to another study on mice, the human equivalent of just two handfuls of walnuts a day cut breast cancer risk in half, and slowed tumor growth by 50 percent as well.

According to Lise Alschuler, author of the Definitive Guide To Cancer: An Integrative Approach to Prevention, Treatment, and Healing, studies on flax lignans demonstrate safety and efficacy in their use against breast cancer, «inhibiting the growth of human estrogen - dependent breast cancer cells in mice and strengthening the tumor - inhibitory effect of tamoxifen».

They help block the ability of cancer cells to produce the tumor invasion enzyme in the first place, in both human colon cancer cells, and human breast cancer.

Veterinary oncologists working with a program at the University of Pennsylvania are treating mammary tumors in shelter dogs with the hope of learning about the progression of breast cancer in humans.

There are many differences between mammary tumors in animals and breast cancer in humans, including tumor type, malignancy, and treatment options