Sentences with phrase «in human cancer cells»

However, he adds that he remains totally committed to this general approach of using human gene editing to study human cancer genes in human cancer cells themselves.

Using CRISPR, I was able to knockout BRAF in a human cancer cell line in about 1 month, which I'd say is pretty amazing.

They tested these drugs one at a time for lethal interaction with 112 different tumor - suppressor gene mutations in human cancer cells growing in the lab.

To validate their computer modeling predictions, researchers performed experiments in human cancer cell lines, mouse liver samples and primary human hepatocytes.

The study, which appears in Science, offers a novel opportunity to develop drugs that could potentially inhibit this pathway in human cancer cells and help control their growth.

Their preliminary findings indicate that MUS81 - induced movement of DNA to the cytosol also occurs in human cancer cells, including prostate cancer, breast cancer, colorectal cancer, uterine cancer, leukemia, and melanoma cells.

With molecular biologist Gregory Hannon of Cold Spring Harbor Laboratory in New York state, Elledge developed genetic tools that examine how genes function in human cancer cells.

In one study, she discovered that inhibiting Aurora - A kinase, an enzyme involved in healthy cell proliferation that is often overexpressed in tumors, could decrease the spread of ovarian cancer in vitro.2 In another project, she found that the transcription factor TWIST1, which regulates aspects of embryonic development, is constitutively degraded in human cancer cells.3

For those in the field, the title of the November 15, 1995 study — «p21 Is Necessary for the p53 - Mediated G1 Arrest in Human Cancer Cells» — says it all.

Azacytidine and Decitabine induce gene - specific and non-random DNA demethylation in human cancer cell lines

But every once in a while, data crop up that don't make sense; for example, a gene called multidrug resistance - 1 (MDR - 1) has been found to frequently have a particular silent mutation in human cancer cells.

Although Waldman now uses newer techniques, he remains committed to using human gene editing to study human cancer genes in human cancer cells themselves.

The most promising silver thiocyanate phosphine complex among these, called UJ3 for short, has been successfully tested in rats and in human cancer cells in the laboratory.

Telomerase activity has been observed in cells made immortal in the laboratory and in human cancer cells.

They also found that drugs that target this newly identified cancer pathway can prevent tumor growth, both in human cancer cells and mice with a form of brain cancer.

On a darker note, the group also has found that Hsp90 enables mutations in human cancer cells to promote cancer growth.

Waldman was beginning his PhD research in Vogelstein's lab at Johns Hopkins when he asked if he could try to «edit» genes in human cancer cells.