Sentences with phrase «in human cancer treatment»

This conditionally licensed MAb technology was inspired by advances in human cancer treatment, and has been «caninized» specifically for use in dogs.

While it is difficult to say at this point what types of cancer might be amenable to such an approach, this new concept could lead to an improvement in human cancer treatment in the long term, the researchers say.

Not exact matches

These nanobots are built to detect cancer cells in the human body and apply treatment directly to them.

Sir John Bell, professor of medical sciences at Oxford University and government advisor on human genomics believes this will transform cancer treatment in the UK.

That's how Charles Sawyers, a 2009 Lasker Award winner and chair of human oncology and pathogenesis at Memorial Sloan - Kettering Cancer Center in New York City, made the connection with Bristol Myers Squibb (BMS) that led to second - generation treatments for chronic myeloid leukemia (CML).

Pseudomonas aeruginosa is usually harmless to humans, but in people with cystic fibrosis (CF) or who have weakened immune systems — such as those who have had an operation or treatment for cancer — it can cause infections that are resistant to antibiotics.

A dozen human studies of MDMA, LSD, a powerful African drug called ibogaine and psilocybin, from so - called «magic mushrooms,» are now under way, testing the once - stigmatized drugs as treatments for not only PTSD, but also cluster headaches and addiction, as well as anxiety and depression in cancer patients.

The findings, in mice and in human stomach cells, also raise questions about how cancer cells may evade treatment.

«Everything we talked about was about research directly on the embryo,» for example, to improve on infertility treatment or better understand cancer biology, says R. Alta Charo, a law professor and bioethicist at the University of Wisconsin Law School who was a member of the NIH Human Embryo Research Panel in the mid-1990s, which considered how embryos might be used in research.

By promoting DNA demethylation, high - dose vitamin C treatment induced stem cells to mature, and also suppressed the growth of leukemia cancer stem cells from human patients implanted in mice.

The research will also enhance understanding of how cancers avoid the immune system, which could have implications for cancer treatment in humans.

The researchers hope that ultimately human trials will prove the efficacy of the OH14 compound in sensitising tumour cells and cancer stem cells to existing drug - based therapies thus disabling tumours from seeding new growth after treatment.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

However, some human tumor cells may also be hard to infect with viral therapies, Dr. Cripe reasoned, and knowing how cells respond in those situations could also be important to improving cancer treatments.

To that end, in collaboration with the University of Zurich and MD Anderson Cancer Center, the researchers tested melanoma tumor samples from human patients undergoing treatment with the same targeted therapies.

Notch is under investigation as a target in the treatment of various cancers and some drugs that target Notch have been well - tolerated by humans.

Someday, targeted inhibition of Hh signaling may be effective in the treatment and prevention of many types of human cancers.

Another is that the transplanted bits of tumor act nothing like cancers in actual human brains, Fine and colleagues reported in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.

The researchers showed that cabazitaxel worked better than docetaxel in human prostate cancer cells lines that were resistant hormone treatment, both in terms of slowing cancer - cell growth and in its ability to kill cancer cells.

This discovery is in line with the recent advances in cancer immunotherapy, a field that focuses on the design of treatments based on the human immune system.

Additional experiments using a combination of maraviroc and a drug that blocks the VEGF protein suggest that the treatment duo could be an effective way to prevent metastatic disease in human breast cancer patients, according to the researchers.

The MasSpec Pen rapidly and accurately detects cancer in humans during surgery, helping improve treatment and reduce the chances of cancer recurrence.

The first child to receive the KTP laser cancer treatment, he was referred to Zeitels after cancer was discovered in a biopsy of what were originally believed to be benign human papilloma virus (HPV) warts.

The use of bone marrow - derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow - and adipose - derived stem cells are being evaluated.

In tumors formed by human breast cancer cells, DNA damage (brown staining) is increased by simultaneous Olaparib treatment and PGAM1 suppression (right) when compared to either Olaparib treatment (left) or PGAM1 suppression (center) alone.

Her research is both translational and clinical in nature and centers on the human genetics of healthy skin aging and diseases related to aging skin, including new treatments for advanced basal cell skin cancers.

«If further studies validate that these processes are critical in human breast cancers,» Koshy notes, «the possibility exists that agents that favorably modify the biophysical properties of the extracellular matrix, or that target the receptors and signaling molecules associated with how cells sense this matrix, could be used as a new avenue for the prevention or treatment of breast cancers.»

The transplantation of isolated human hematopoietic stem cells is used in the treatment of anemia, immune deficiencies and other diseases, including cancer.

So - called cancer immunotherapy — which is the treatment of tumors by the use of antibodies — has been established and used very successfully in human medicine for about 20 years.

The first anti-EGFR antibody (cetuximab) for cancer treatment in human medicine was developed by the company Merck.

And because their signal blocker is an antibody already in phase I clinical trials for cancer treatment, they're hoping to make a quick jump into human testing for cardiovascular disease.

Richard Lindsay, a PhD student who worked on the research team, added: «Our findings are of central importance in understanding how microbial infections evolve, but also have wider significance for the treatment of cancer and the therapeutic control of disease in humans, animals and plants.»

«We are at a point in our research where we have validated the efficacy of this combination treatment approach in preclinical animal models, and we now need to define its safety through toxicology and pharmacology studies,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Medicine.

Buoyed by these results, Dana - Farber researchers are working to create a derivative of dBET1 that can be used as a drug in human patients — and to extend the conjugate strategy for the treatment of other cancers and other genetically - caused diseases.

After confirming in mouse models that cells from HER2 - positive breast cancers became resistant to anti-HER2 treatment when implanted into the brain but not into other tissues, the investigators found that HER3 is overexpressed in brain metastases of HER2 - positive breast cancers from both mice and human patients.

To test this in a treatment situation, Peter collaborated with Dr. Shad Thaxton, associate professor of urology at Feinberg, to deliver the assassin molecules via nanoparticles to mice bearing human ovarian cancer.

«Based on this research, we are now conducting a first - in - human study combining the PARP inhibitor with radiation and chemotherapy in patients with locally advanced pancreatic cancer, with an ultimate goal of improving survival rates and treatment outcomes,» said Tuli.

This study provides one of the first animal models to demonstrate the long - term cognitive deficits resulting from a chemotherapeutic treatment used in treating humans for breast cancer.

In fact, large human liver cancer tumors on comparatively small mice started regressing about 20 days after treatment, and were eradicated by day 41 with the help of one of the targeted receptors.

The accumulation of mutations in the human genome is at the origin of cancers, as well as the development of resistance to treatments.

Pet dogs may be humans» best friends in a new arena of life: cancer treatment, said University of Illinois veterinary clinical medicine professor Timothy Fan.

To determine whether the reactivation of methylation - silenced genes by EGCG is a general phenomenon that also occurs in other cell lines, we studied the effects of EGCG treatment on the methylation status and mRNA levels of p16INK4a or RARβ in three other human cancer cell lines (Fig. 3C) ⇓.

In a 1988 paper summarizing his findings, Fiebig concluded that xenograft mice were wonderful models for broadly testing new drugs against human tumors, but they «can not be used as a clinical routine method» for predicting patient treatment.1 The idea of using xenograft mice as personal avatars for cancer patients was discarded.

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have discovered a peripheral biomarker in human blood serum that can be used to detect the presence and progress of glioblastoma brain tumors before and after treatment.

Sipuleucel - T is the first human cancer treatment vaccine to be approved in the United States.

This center fosters collaborations among researchers at MD Anderson Smithville, in Houston and with other instutions in central Texas to reach the goal of understanding how environmental exposures influence cancer outcomes in the human population by identifying new targets and strategies for cancer prevention and treatment.

LA JOLLA, CA — Discovering that mouse hair has a circadian clock — a 24 - hour cycle of growth followed by restorative repair — researchers suspect that hair loss in humans from toxic cancer radiotherapy and chemotherapy might be minimized if these treatments are given late in the day.

«In particular, his approach can be thought of as a very advanced biological therapy for the treatment of breast cancer; one that uses viruses, which are better recognized to cause disease, to treat human breast cancers.»

Other HDAC inhibitors are in development for cancer treatment, and these, rather than trichostatin A, are more likely candidates for human SMA trials in the future.

MD Anderson is working closely with Guardant to expand a highly specialized CLIA - accredited lab (CLIA labs comply with federal standards known as the Clinical Laboratory Improvement Amendments that regulate all clinical laboratory testing on humans), and pre-CLIA labs, where Guardant's digital sequencing technology will be used to create disease - specific assays that will be transferred for use in the CLIA - accredited lab to help detect cancers early and guide treatment.