«Given the long and established history of curcumin as a spice and herbal medicine, its demonstrated chemopreventive and therapeutic potential, and its pharmacological safety in model system, curcumin, the bioactive extract of curcumin, promises a great future
in human clinical studies designed to prevent and / or delay age - related diseases,» explained the authors of a review on these and other animal studies involving curcumin.
* VitaMK7 ® is shown
in human clinical studies to increase osteocalcin (calcium - binding protein) levels, enhancing the body's ability to utilize calcium in the bloodstream.
Even
in human clinical studies, a variety of variables between different people muddy the waters too much for a clear picture.
Among this class of derivatives, compound 2 (AMD070, AnorMED) is particularly notable due to its significant anti-HIV efficacy
in human clinical studies [86].
Therefore, PRP has the potential to aid in the healing of multiple acute and chronic injuries; however, the benefit of PRP
in human clinical studies has not been proven;
Not exact matches
The striking example I focused on then was the cancer drug Avastin, developed by Genentech (now Roche)-- which, at the time, had been
studied in at least 400 completed
human clinical trials for various cancers.
Strikingly for Agios and partner Celgene, the therapy was
in human clinical testing not so long ago (there was just a three year gap between the first
human studies and Agios» regulatory submission to the FDA).
Dr. Eastwood has an undergraduate degree
in Human Biology from Stanford University, and a doctorate
in clinical psychology from the California Institute of Integral
Studies.
In addition to publishing a number of book chapters and journal articles, Mr. Trout has produced 14 clinical training videos that are used by universities and clinics around the world, including the six - hour video training series, The Awakening and Growth of the Human: Studies in Infant Mental Healt
In addition to publishing a number of book chapters and journal articles, Mr. Trout has produced 14
clinical training videos that are used by universities and clinics around the world, including the six - hour video training series, The Awakening and Growth of the
Human:
Studies in Infant Mental Healt
in Infant Mental Health.
Except for the
study cited above, there have been no other reports of
clinical problems
in infants of mothers with silicone breast implants.21 It is unlikely that elemental silicon causes difficulty, because silicon is present
in higher concentrations
in cow milk and formula than
in milk of
humans with implants.22 The anticolic compound simethicone is a silicone and has a structure very similar to the methyl polydimethylsiloxane
in breast implants.
The PhD course focuses on various aspects of
human (donor) milk, with as main
study a randomized clinical trial towards the effects of human donor milk in very low birth weight infants (the Early Nutrition St
study a randomized
clinical trial towards the effects of
human donor milk
in very low birth weight infants (the Early Nutrition
StudyStudy).
She received her undergraduate degree
in Human Development and Family
Studies from Indiana University
in Bloomington, Indiana and her graduate degree
in Clinical Mental Health Counseling from Indiana University of Pennsylvania.
The
clinical trial
in humans was based on positive results of a
study in mice published
in Nature Communications
in Sept. 2015.
Mitchell guesses that there will probably be 10 more years of rigorous testing
in animals before moving on to
human clinical studies.
The
study may lead to
clinical trials
in humans.
This
clinical study, published
in the Proceedings of the National Academy of Sciences, tested the possibility of imaging inflammation
in the pancreas of
human volunteers using ferumoxytol, a coated iron nanoparticle approved by the FDA as an iron replacement therapy, and MRI.
This
study represents a significant step towards the development of
clinical trials
in gene therapy for the curative treatment of hereditary deafness and balance loss
in humans.
But given its low cost, availability and safety history further
study in a
clinical trial to test its effectiveness against Zika virus
in humans is merited.»
«We have now found a potential mechanism, and at this point
in our research, we need to test
human participants
in a blinded, placebo controlled
clinical study — the same technique we used to
study the behavioral effects of acupuncture
in rats,» says Eshkevari, a nurse anesthetist and licensed acupuncturist.
«The
study results elucidate the molecular mechanisms underlying disease progression
in multiple sclerosis models, providing a basis for future
clinical trials to determine safety and efficacy of these chemical agents
in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the
study.
This proof - of - principle
study shows «for the first time... that
human iPS cells can be used to model a diverse range of inherited diseases
in adult cells,» the authors wrote
in their paper, published online
in The Journal of
Clinical Investigation August 25.
Researchers who conduct animal
studies often don't use simple safeguards against biases that have become standard
in human clinical trials — or at least they don't report doing so
in their scientific papers, making it impossible for readers to ascertain the quality of the work, an analysis of more than 2500 journal articles shows.
«These results provide the basis for the potential implementation of 5 - LO - inhibitors as stem cell therapeutic agents for a sustained AML cure, although this must be investigated further
in preclinical and
clinical studies in humans,» explains Dr. Ruthardt.
These techniques include:
human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient
in a dish»); «body on a chip» devices, where
human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual
clinical trials; and microdosing
studies, where tiny doses of drugs given to volunteers allow scientists to
study their metabolism
in humans, safely and with unsurpassed accuracy.
Although we can not determine what the effects of AF267B will be
in humans until
clinical trials are complete, we are very excited by the results our
study has yielded.»
The IU team is now planning
studies in animals and, ultimately, will look to others to partner on
clinical trials that implement the new treatment
in humans.
Next, researchers would like to
study how the two - drug approach works
in humans, although no
clinical trials have yet been designed or scheduled.
Often, those smaller animals express the genetic abnormality very differently from
humans, says
clinical scientist and pediatric neurologist James Dowling at the University of Michigan, Ann Arbor, who
studies the myopathies and their genetic causes
in both children and zebrafish.
Regulatory issues must be addressed before moving to
human studies, Davies said, but the findings published
in the August issue of the Journal of
Clinical Investigation suggest that it may be possible to manipulate the bacterial residents of the gut — the gut microbiota — to treat obesity and other chronic diseases.
The team behind the new
study looked specifically at the information researchers prepare to justify
clinical trials
in humans, which can cost millions of dollars.
Once we have demonstrated the proof of concept
in animal
studies, the next goal will be to work towards the first
human clinical trial with graphene devices during intraoperative mapping of the brain.
«These pet - animal
studies have been extremely helpful
in making decisions on whether to go into
human clinical trials.»
«Our partnership with families who have a child with Down syndrome and our investment
in a comprehensive
clinical data and biorepository will continue to provide resources to
study not only heart defects, but also other Down - syndrome associated medical conditions such as cognitive function, leukemia, and dementia,» says co-author Stephanie Sherman, PhD, professor of
human genetics at Emory University School of Medicine.
«While this
study took place
in mice, the work sets the scene to do early
clinical trials
in humans.
With a view to
clinical studies (tests on
humans) it is important to note that the effects on the tumor vasculature were even observed at chloroquine concentrations that had little effect on autophagy
in the cancer cells.
Aucott will feature the joint
study as an example
in his 2016 AAAS Annual Meeting presentation, Big Data
Clinical Realities and the
Human Dimensions of Interoperable Data.
«Nevertheless, this
study identified mechanisms suitable to explore damage and protection on the vasculature
in humans, paving the way for future
clinical studies.»
Although further work would be needed to validate the results
in humans, the
study suggests that a simple blood test along with other
clinical indicators could potentially be used to diagnose the disease, the researchers say.
The discovery of an unexpected biochemical link within tumor cells should lead to
clinical trials for experimental drug treatments that indirectly target myc and that already are being evaluated
in human studies, the researchers said.
Among those is canine compulsive disorder (CCD), the counterpart to
human obsessive compulsive disorder (OCD),» says the
study's first and corresponding author Nicholas Dodman, BVMS, DACVA, DACVB, professor
in clinical sciences and section head and program director of animal behavior at Cummings School of Veterinary Medicine at Tufts University.
Human epidemiology
studies in populations
in different geographic locations, as well as
clinical and molecular
studies, show that Merkel cell polyomavirus causes Merkel cell carcinoma.
Since CGP3466B has already been tested
in phase II
clinical trials to (unsuccessfully) treat Parkinson's disease and ALS, it is known to be safe for
humans, but the researchers caution that many more years of
studies are needed to definitively show whether it is effective for preventing cocaine damage, first
in mice, then
in humans.
AAV viral particles are
in clinical trials for other purposes, making the researchers optimistic that this CRISPR delivery method could be used
in humans, although more
studies are needed.
«The malfunction
in this protein has not been previously linked to
clinical disorders of the
human immune system,» said Ivona Aksentijevich, M.D., staff scientist
in NHGRI's Medical Genetics Branch and
study co-author.
Like 80 % of
humans infected with the Zika virus, most of the non-human primates used
in this
study lacked any apparent
clinical symptoms.
The Thorough QT
clinical assessment also has its limitations, as those
studies are done
in humans and typically require large numbers of patients.
«By helping us understand that lower levels of RNF125 confer resistance to BRAF inhibitors, we have a new strategy to stratify patients for currently approved therapy versus participation for
human clinical trials to investigate whether targeting JAK1 will be more effective
in patients whose tumors exhibit reduced RNF125,» said Keith T. Flaherty, M.D., associate professor, Harvard Medical School, and director of Developmental Therapeutics, Cancer Center, Massachusetts General Hospital, and co-author of the
study.
In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditio
In a novel animal
study design that mimicked
human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment
in a mouse model of the neurodegenerative conditio
in a mouse model of the neurodegenerative condition.
Published
in the Journal of
Clinical Investigation, the
study collected metabolic data directly from more than 120
human lung cancer patients.
Melina R. Kibbe, M.D., of the University of North Carolina at Chapel Hill (formerly of Northwestern University, Chicago), and Editor, JAMA Surgery, and colleagues conducted a
study to determine if sex bias exists
in human surgical
clinical research, if data are reported and analyzed using sex as an independent variable, and to identify specialties
in which the greatest and least sex biases exist.