Sentences with phrase «in human estrogen»

Dr. Mack's research has focused primarily on the use of novel antitumor agents in human estrogen receptor negative breast tumor cells, and more recently, on the use of bioflavonoids in the regulation of estrogen receptor positive (ER +) and estrogen receptor negative (ER --RRB- breast tumor cell proliferation.

Not exact matches

BPA, the synthetic estrogen, is used to soften the plastic that lines the can; colas contain caramel coloring shown to cause cancer in humans; and citrus - flavored sodas contain BVO, a flame retardant used in rocket fuel that may reduce fertility and negatively affect thyroid hormones.

Likewise, the phytoestrogens in soy have not only been shown to be metabolized differently than real estrogen (such as that in cows milk), in humans as opposed to rats, but have shown a wide array of anti-cancer effects, including cancers instigated by sex hormones such as estrogen!

More famously, though, soy contains phytoestrogens — chemicals that act like the hormone estrogen in the human body.

For one thing, the beans contain a substance that behaves very much like estrogen in the human body — which has the potential to increase cancer risks, as well as contribute to developmental problems in children.

Soy has also been found to be estrogenic — meaning that it can significantly raise estrogen levels in the human body.

Although they are produced by plants, these chemicals behave life estrogen in the human body, upsetting the natural hormonal balance.

Soy also contains chemicals known as phytoestrogens — substances that act like estrogen in the human body.

The causes for such nausea are not certain, but it is suspected that it is your body's reaction to the rapid changes in hormonal levels such as those of estrogen, progesterone, and hCG (human Chorionic Gonadotropin).

Second, the hormone cocktail of estrogen, human chorionic gonadotropin (hCG), progesterone, and prolactin, which helps to produce breast milk, is in full force, causing breast tissue to grow.

In the human body, BPA mimics the hormone estrogen.

The chemical mimics estrogen in the human body, scientists say.

The report from the American Academy of Pediatrics also referred to theories that some of the hormones in soy protein formulas can interfere with an infant's reproductive development because of their similarity to the human sex hormone estrogen.

These hormones include Estrogen and human Chorionic Gonadotropin (hCG) which help in maintaining the pregnancy.

High total and saturated fat intake were associated with greater risk of estrogen receptor - and progesterone receptor - positive (ER+PR +) breast cancer (BC), and human epidermal growth factor 2 receptor - negative (HER2 --RRB- disease, according to a new study published April 9 in the Journal of the National Cancer Institute.

Previous research had suggested that levels of BPA, which mimics the female hormone estrogen in the human body, declined by 50 percent every five hours after it was ingested in foods or water it had leached into from plastic containers.

Bloch's colleagues at the National Institute of Environmental Health Sciences tested the oils in gene expression studies on lab - grown human breast cancer cells and found that they could mimic estrogens, the primary female sex hormones, and inhibit androgens, the primary male sex hormones.

Scientists believe that it produces such a wide range of health effects in low doses because it mimics the hormone estrogen, disrupting human development and making it particularly potent for infants.

When BPA hits cell receptors, it is as powerful as estradiol, the most potent estrogen in humans.

In the study, human melanocytes — the cells that produce the skin pigment melanin — were exposed to estrogen levels usually seen during pregnancy.

Using in vitro, or test tube, experiments, the researchers applied these chemicals to human cancer cells to measure changes of estrogen receptor - and androgen receptor - target genes and transcriptional activity.

The sensor sends an electronic signal is the presence of estrogen and, with further development, could test estrogen levels in bodily fluids or test waterways for estrogen contamination that might pose a risk to humans and the environment.

The hormone estrogen plays an important role in the human body and has been linked to everything from tumor growth to neuron loss during Alzheimer's disease.

«Estrogens perform important biological functions not only in sexual development and reproduction, but also in modulating many other processes impacting health and diseases in human and animals,» Beinhauer said.

In the 1930s BPA was identified as a potent mimic of estrogen; it could bind to the same receptors throughout the human body as the natural female hormone.

The reason, according to the research published in the journal Human Reproduction (pdf): soy beans contain high amounts of phytoestrogens, organic compounds that mimic the female hormone estrogen in the human body and, in animal studies, have been shown to reduce testosterone leHuman Reproduction (pdf): soy beans contain high amounts of phytoestrogens, organic compounds that mimic the female hormone estrogen in the human body and, in animal studies, have been shown to reduce testosterone lehuman body and, in animal studies, have been shown to reduce testosterone levels.

«Our studies are beginning to corroborate the idea that environmental estrogen may be associated with endometriosis,» said Germaine Buck - Louis, director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development's epidemiology division in Maryland.

In humans, the ovaries stop releasing estrogen after they run out of eggs.

Since the worms survive on microbes that degrade the sewage, the treatment - plant starlings consumed natural human estrogen along with three estrogen mimics: DEHP, used to manufacture polyvinyl chloride; DBP, found in nail polish; and bisphenol A, common in hard plastic bottles.

When exposed to estrogen, an area in the brain's memory hub that is typically suppressed during such tasks instead activated in those with the uniquely human gene variant.

The example shown reveals that these estrogen agonists show the strongest connectivity to each other in MCF7, a human breast cancer cell line that expresses the estrogen receptor.

The effects of androgens and estrogens on preadipocyte proliferation in human adipose tissue: influence of gender and site

In humans, DHEA is produced in the adrenal gland, gonads and brain, and is a precursor for testosterone and estrogeIn humans, DHEA is produced in the adrenal gland, gonads and brain, and is a precursor for testosterone and estrogein the adrenal gland, gonads and brain, and is a precursor for testosterone and estrogen.

Zhu Q, Jin L, Casero RA, Davidson NE, Huang Y. Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tranEstrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) tranestrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

In the early 1970s, the tragic health impacts of diethylstilbestrol (DES), an estrogen - based drug that was thought to prevent miscarriage, introduced the possibility of hormone disruption as a threat to human health and development that sparked intensive study of estrogens in the environmenIn the early 1970s, the tragic health impacts of diethylstilbestrol (DES), an estrogen - based drug that was thought to prevent miscarriage, introduced the possibility of hormone disruption as a threat to human health and development that sparked intensive study of estrogens in the environmenin the environment.

In this report the American Council on Science and Health (ACSH) explores the endocrine disrupter hypothesis, which asserts that certain (primarily man - made) chemicals act as, or interfere with, human hormones (specifically estrogens) in the body and thus cause a range of defects and diseases related to the endocrine systeIn this report the American Council on Science and Health (ACSH) explores the endocrine disrupter hypothesis, which asserts that certain (primarily man - made) chemicals act as, or interfere with, human hormones (specifically estrogens) in the body and thus cause a range of defects and diseases related to the endocrine systein the body and thus cause a range of defects and diseases related to the endocrine system.

Humans are exposed through their diet to estrogenic substances (substances having an effect similar to that of the human hormone estrogen) found in many plants.

These results, also presented at the 2015 European Cancer Congress (ECC2015, abstract # 5BA) today, which involve the group of 1,626 patients with a Recurrence Score between 0 and 10, demonstrated that 99.3 percent of node - negative, estrogen receptor (ER)- positive, human epidermal growth factor receptor 2 (HER2)- negative patients who met accepted guidelines for recommending chemotherapy in addition to hormonal therapy, had no distant recurrence at five years after treatment with hormonal therapy alone.

We're going to focus on six hormones that have the profoundest effect in this respect: insulin, testosterone, estrogen, cortisol, human growth hormone and the thyroid hormones.

The lowdown: That plus sign on your pregnancy test means there is human chorionic gonadotropin (hCG), a hormone made by the placenta after conception, in your system — sending estrogen and progesterone levels surging.

Many women are «triple negative» No one yet knows precisely why, but African - American women are roughly twice as likely as white women to have triple - negative breast cancer — so called because tumor cells in this particularly aggressive form of the disease test negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER - 2).

This is partly due to reduction in the production of hormones such as testosterone, human growth hormone and estrogen and also because of lack of weight - bearing activity.

Conjugated linoleic acid (CLA) up - regulates the estrogen - regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells.

Oxybenzone — This substance has been shown in studies to be a potent hormone disruptor, mimicking estrogen within the human body and potentially leading to diseases such as breast cancer, endometriosis, decreased sperm count, and prostate and testicular cancers.

Hormones: estrogens and anabolic steroids used in bodybuilding like testosterone and human growth hormone.

This combination occurs mostly in women and men that are overweight and in people who were exposed to xenoestrogens, which are synthetic or natural substances (not produced by the body) that mimic human estrogen.

In a group of women 65 to 80 years of age who had never used hormone replacement therapy of any kind, blood levels of estradiol (one of the human estrogens) were measured.

Soybeans also contain phytoestrogens, which mimic the estrogen produced in the human body.

Phthalates act as powerful xenoestrogens, and have been linked to various estrogen - sensitive cancers and other conditions in humans.