Sentences with phrase «in human lung cancer»

RNA expression of LAG3 (red), CD274 (green) gene in human lung cancer tissue using RNAscope ® 2.5 HD Duplex Assay

23) Starczynowski DT, Lockwood WW, Delehouzee S, Chari R, Wegrzyn J, Fuller M, Tsao M, Lam S, Gazdar AF, Lam WL, Karsan A (2011) TRAF6 is an amplified oncogene bridging the RAS and NF - κB pathways in human lung cancer.

«For example, mouse mammary tumors shared a signaling pathway that is found in human lung cancer and controls how cells reproduce and move from one location to another.»

By using molecular genetic tools to reduce the amount of PC in human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and other cells), and a reduced rate of tumor growth in mice.

A high proportion (46 - 47 %) of C / A or G / T transversions, similar to the chemical - carcinogen signatures observed in human lung cancers.

38) Yamamoto H, Shigematsu H, Nomura M, Lockwood WW, Sato M, Okumura N, Soh J, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Date H, Lam WL, Minna JD, Gazdar AF (2008) PIK3CA mutations and gene copy number in human lung cancers.

Not exact matches

Granted, there are more benefits to reducing particulate and greenhouse gas emissions than just climate change, i.e. PM 2.5 which can be stuck in the human lung and cause cancer / respiratory issues, SO2 which contributes to acid rain (we've already eliminated the majority of this problem), as well as soot (nobody wants the surrounding area covered in ash).

There has never been a randomized, prospective, controlled study in humans on cigarette smoking, but we have still been able to determine that it causes lung cancer.

In human terms, the costs of lives and families damaged by heart disease, strokes, cancer and lung disease are incalculable.

Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory - grown, human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward lung cancer develoCancer Center say they have preliminary evidence in laboratory - grown, human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward lung cancer develocancer development.

Classified as a known human carcinogen, it is linked to lung, kidney and prostate cancer in workers.

Professor Heiner Boeing, also from the German Institute of Human Nutrition, added, «In addition to the many noted benefits for cardiovascular health, and risk of lung disease and cancer, it is clear that dental health is yet another reason not to take up smoking, or to quit smoking now.»

In their latest study, they tested compounds against cells from nine different types of human cancer, including common types affecting blood, colon, breast, prostate, ovaries, kidneys, and lungs.

The scientists identified several, including the investigational cancer drug BEZ235, which blocked a key metabolic pathway in flu - infected human lung epithelial cells.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

They found out that TiY is capable of distinguishing TICs from non-TICs in various human lung cancer cell lines and patient - derived lung tumors.

Beyond lung cancer, TiY is able to target TICs in 28 types of human cell lines derived from the central nervous system, melanoma, breast, renal, ovarian, colon, and prostate cancer.

«Our study results suggest a new drug cocktail that is effective in both human lung cancer cell lines and fly models,» says Cagan.

Finally, a Calgary, Alberta — based company, Oncolytics Biotech, is testing a reovirus (an RNA virus often found in human lungs but thought to be nonpathogenic) against several types of cancer, including that of the lung and skin as well as head and neck malignancies.

She expects she will find laminum - 8 uniquely overexpressed in other invasive cancers, like lung and colon cancer, but to date she has tested for it in only human brain and metastatic breast cancer.

One of those genes, K - Ras, which was discovered nearly 30 years ago, is mutated in 30 percent of human tumors, including 90 percent of pancreatic cancers, 40 percent of colon cancers, and 20 percent of non-small cell lung cancers.

According to the National Cancer Institute, more than a third of all human cancers, including a high percentage of pancreas, lung and colon cancers are driven by mutations in a family of genes known as Ras.

By producing the metabolite 2 - phosphoglycerate, PGAM1 regulates several different metabolic pathways, and the levels of this enzyme are abnormally elevated in various human cancers, including breast cancer, lung cancer, and prostate cancer.

Published in the Journal of Clinical Investigation, the study collected metabolic data directly from more than 120 human lung cancer patients.

B - raf gene mutations have known roles in the development of many human cancers including melanoma, lung and thyroid cancer.

«We now know much more about metabolic reprogramming of cancerous tissues in human patients, particularly that the activation of pyruvate carboxylase is important to lung cancer cell growth and survival,» said Fan, UK professor of toxicology and faculty member of the Markey Cancer Center and CESB at the University of Kencancer cell growth and survival,» said Fan, UK professor of toxicology and faculty member of the Markey Cancer Center and CESB at the University of KenCancer Center and CESB at the University of Kentucky.

The machines handle the decaying element's radiation better than human miners and can tolerate the radon gas released by the ore; early Navajo miners of uranium in the U.S. — and their families exposed to residual radioactive dust and debris as well as contaminated water — developed lung cancer and other ailments by the 1970s and 1980s.

They also tested other cancer lines — human cervical, lung and prostate cancers — and found that they responded to the patterned tumor environments in the same way.

In 2015, Tomasetti and Vogelstein published a widely covered Science paper that found that R mutations explain the dramatic variation in cancer incidence among human tissues better than hereditary or environmental factors — helping to illuminate why tissues in the lung or colon give rise to cancer far more frequently than tissues in bone or brain, for examplIn 2015, Tomasetti and Vogelstein published a widely covered Science paper that found that R mutations explain the dramatic variation in cancer incidence among human tissues better than hereditary or environmental factors — helping to illuminate why tissues in the lung or colon give rise to cancer far more frequently than tissues in bone or brain, for examplin cancer incidence among human tissues better than hereditary or environmental factors — helping to illuminate why tissues in the lung or colon give rise to cancer far more frequently than tissues in bone or brain, for examplin the lung or colon give rise to cancer far more frequently than tissues in bone or brain, for examplin bone or brain, for example.

The cells exhibited many functions associated with tumor progression; their presence within mouse tumors substantially accelerated cancer growth, and in human lung tumors, a SiglecFhigh neutrophil signature was associated with poor patient survival.

In a letter published in the cancer journal Annals of Oncology, researchers led by Professor Jean - Philippe Spano, head of the medical oncology department at Pitie - Salpetriere Hospital AP - HP in Paris, France, report that while treating an HIV - infected lung cancer patient with the cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapIn a letter published in the cancer journal Annals of Oncology, researchers led by Professor Jean - Philippe Spano, head of the medical oncology department at Pitie - Salpetriere Hospital AP - HP in Paris, France, report that while treating an HIV - infected lung cancer patient with the cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapin the cancer journal Annals of Oncology, researchers led by Professor Jean - Philippe Spano, head of the medical oncology department at Pitie - Salpetriere Hospital AP - HP in Paris, France, report that while treating an HIV - infected lung cancer patient with the cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapin Paris, France, report that while treating an HIV - infected lung cancer patient with the cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapin the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapin the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapy.

However, scientists at SFU, the University of British Columbia and the B.C. Cancer Agency have discovered that many non-coding RNAs are perturbed in cancerous human cells, including breast and lung, in a specific way.

The findings, now published in PLOS Genetics, reveal how mice can actually mimic human breast cancer tissue and its genes, even more so than previously thought, as well as other cancers including lung, oral and esophagus.

Exposure in humans can lead to heart disease, stroke, lung cancer and other health problems.

These compounds cause cancer in laboratory animals, and studies of industrial workers strongly suggest they can cause lung cancer in humans too.

This week it emerged that the first human test of the controversial gene - editing technique CRISPR had taken place at West China Hospital in Chengdu, where oncologists used it to treat a man with an aggressive lung cancer.

The consensus on human - caused climate change is among the strongest observed in the sciences — about as strong as the consensus surrounding the link between smoking and lung cancer.

They showed that it slowed the growth of human lung cancer cells but not kidney cancer cells in these mice.

Arsenic is a naturally occurring element that is toxic to humans in some forms, and can cause skin, lung and bladder cancers, and other diseases.

Being both tumor - specific and widely expressed in human tumors, MAGE - A3 is an ideal cancer vaccine target and will be the focus of many clinical trials, including the largest clinical trial ever conducted in lung cancer, MAGRIT, launched by GlaxoSmithKline in 2007.

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

Wang's team discovered that if human lung cancer cells in a lab dish in the presence of the receptor were treated with BCX, they migrated less than untreated ones.

Management of chemotherapy - related anaemia with low - dose recombinant human erythropoietin in patients with small cell lung cancer.

Previous studies have implicated FOXM1, which encodes a transcription factor protein capable of regulating the activity of many other genes, in many other human cancers, including liver, breast, lung, prostate, colon, and pancreatic cancers.

Mutation rates ten-fold higher than typical lung cancers in humans, though within three-fold of «hypermutator» tumors with mutations in DNA repair genes.

Their findings, published last week in the Proceedings of the National Academy of Sciences, may provide clues for understanding how some forms of human lung cancer initiate and may also aid in the development of tools for successful gene therapy of lung diseases such as cystic fibrosis.

Miller said that the viral receptor gene, HYAL2, was located on a region of human chromosome 3 that is frequently altered in lung cancers.

In this fashion, they derive a signal from the tumor cells proportional to tumor mass which arises spontaneously in vivo in the accurate setting of the lung and from the accurate genetic lesions found in human non-small cell lung cancer (NSCLCIn this fashion, they derive a signal from the tumor cells proportional to tumor mass which arises spontaneously in vivo in the accurate setting of the lung and from the accurate genetic lesions found in human non-small cell lung cancer (NSCLCin vivo in the accurate setting of the lung and from the accurate genetic lesions found in human non-small cell lung cancer (NSCLCin the accurate setting of the lung and from the accurate genetic lesions found in human non-small cell lung cancer (NSCLCin human non-small cell lung cancer (NSCLC).

«We developed a new method of initiating lung cancer in mice, which has properties associated with human lung cancer, and used this model to identify the role of this enzyme in cancer proliferation.

LA JOLLA — Scientists at the Salk Institute have uncovered a molecule whose mutation leads to the aggressive growth of a common and deadly type of lung cancer in humans.