Sentences with phrase «in human melanomas»

We also confirmed the expression of OR2C3 in human melanomas, but not in normal melanocytes.

Intracellular retention of the NKG2D ligand MHC class I chain - related gene A in human melanomas confers immune privilege and prevents NK cell - mediated cytotoxicity.

«It is anticipated that this novel compound will have significant efficacy in human melanomas and other cancers either as a stand - alone therapy or in combination with other targeted or immune - based therapies,» explained co-corresponding author Rhoda Alani, MD, the Herbert Mescon Chair of Dermatology at Boston University School of Medicine (BUSM).

«What's cool about this group of genes is that they also get turned on in human melanoma,» says Zon, who is also a member of the Harvard Stem Cell Institute and a Howard Hughes Medical Institute investigator.

After exploiting a technology that allowed them to activate each of nearly 16,000 genes individually in human melanoma cell lines containing mutant BRAF, the authors then treated the panel of cells with the drugs and monitored which cells showed altered drug sensitivity.

The researchers also identified a pharmacological way through which FES expression can be restored in human melanoma.

Prof. Marine and his research team also identified a pharmacological way of restoring the expression of FES in human melanoma.

The Reproducibility Project did not attempt to replicate this finding, but subsequent studies have reported the frequency of PREX2 mutations in human melanoma (Hodis et al., 2012; Krauthammer et al., 2012; Marzese et al., 2014; Ni et al., 2013; Turajlic et al., 2012), including meta - analysis of 241 melanomas (Xia et al., 2014).

Up - regulated expression of zonula occludens protein - 1 in human melanoma associates with N - cadherin and contributes to invasion and adhesion.

Mukherji B, Chakraborty NG, Yamasaki S, Okino T, Yamase H, Sporn JR, Kurtzman SK, Ergin MT, Ozols J, Meehan J, Mauri F. Induction of antigen - specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide - pulsed autologous antigen presenting cells.

ab85137 staining S100 in a human melanoma cell line by Flow Cytometry.

A p16INK4a - insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.

Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma.

Not exact matches

In 2000, Medarex began its first phase of human testing on its new «CTLA -4-blockade» — in patients who had either prostate cancer or metastatic melanoma, a deadly form of skin canceIn 2000, Medarex began its first phase of human testing on its new «CTLA -4-blockade» — in patients who had either prostate cancer or metastatic melanoma, a deadly form of skin cancein patients who had either prostate cancer or metastatic melanoma, a deadly form of skin cancer.

Prof. Marine and his team generated a refined mouse model that faithfully reproduces the early stages of melanoma development in humans.

So what is the association between melanocortin - 1 (MC1R) receptor and melanoma risk in humans after controlling for sun exposure?

To that end, in collaboration with the University of Zurich and MD Anderson Cancer Center, the researchers tested melanoma tumor samples from human patients undergoing treatment with the same targeted therapies.

In experiments with mice, the UC San Diego - led team showed that verteporfin also suppresses the growth of uveal melanoma tumors derived from human tumors.

Beyond lung cancer, TiY is able to target TICs in 28 types of human cell lines derived from the central nervous system, melanoma, breast, renal, ovarian, colon, and prostate cancer.

The study, led by researchers at Boston University School of Medicine (BUSM), reports sporadic mutations in the APC / C protein complex, specifically in the essential protein component Cdh1, which may predispose humans to developing melanoma from the loss of the APC / C protein complex.

In one experiment this year, a team led by another CRISPR pioneer, Feng Zhang of the Broad Institute in Cambridge, Massachusetts, targeted the 20,000 or so known human genes, turning them on one by one in groups of cells to identify those involved in resistance to a melanoma druIn one experiment this year, a team led by another CRISPR pioneer, Feng Zhang of the Broad Institute in Cambridge, Massachusetts, targeted the 20,000 or so known human genes, turning them on one by one in groups of cells to identify those involved in resistance to a melanoma druin Cambridge, Massachusetts, targeted the 20,000 or so known human genes, turning them on one by one in groups of cells to identify those involved in resistance to a melanoma druin groups of cells to identify those involved in resistance to a melanoma druin resistance to a melanoma drug.

However, it has not been possible to test whether sunscreens prevent melanoma, because these are generally manufactured as cosmetics and tested in human volunteers or synthetic skin models.

One of these, UJ3, is as effective as the industry - standard drug Cisplatin in killing cancer cells in laboratory tests done on human esophageal cancer, breast cancer and melanoma.

In one published study, where we put melanoma cells into mice, we published it with mouse melanoma cells, but we repeated it with human cells.

The rarity is very similar in both humans and fish, which suggests that the underlying process of melanoma formation is probably much the same in humans.»

The Ogretmen laboratory screened previously reported microarray data sets of several human tumor tissues (metastatic head and neck squamous cell carcinoma, melanoma, and renal cell carcinoma) and showed that, in these samples, only the levels of CerS4 were significantly decreased.

These DNA elements have epigenetic functions that are similar in zebrafish and human melanoma and could potentially be targeted with drugs to stop a mole from becoming cancerous.

The research team analyzed BRAF inhibitor resistance in melanoma cell lines, mice bearing human melanoma tumors, and in human tumor biopsy samples.

B - raf gene mutations have known roles in the development of many human cancers including melanoma, lung and thyroid cancer.

As a result, the researchers were able to prevent the growth and malignant spread of the cancer in the animal model and human melanoma cells.

Betulinic acid also shrank human melanomas induced in mice.

Their preliminary findings indicate that MUS81 - induced movement of DNA to the cytosol also occurs in human cancer cells, including prostate cancer, breast cancer, colorectal cancer, uterine cancer, leukemia, and melanoma cells.

Taking advantage of these «simplified» versions of melanoma, the researchers identified a dozen of new genes that are likely to play key roles in the initiation and / or progression of human melanoma.

Unexpectdly the expression of FES, which encodes a kind of protein better known for their ability to promote cancer development -, is lost in a large fraction of human melanoma.

While past attempts to treat melanoma failed to meet expectations, an international team of researchers are hopeful that a compound they tested on both mice and on human cells in a petri dish takes a positive step toward creating a drug that can kill melanoma cancer cells without harming nearby healthy cells.

In the study, the compound caused human melanoma cells to die and inhibited tumor growth by about 69 percent in a mouse modeIn the study, the compound caused human melanoma cells to die and inhibited tumor growth by about 69 percent in a mouse modein a mouse model.

In a series of studies led by Dr. Arun Sharma, associate professor of pharmacology and Dr. Shantu Amin, professor of pharmacology, both of Penn State College of Medicine, researchers designed and synthesized a compound called napthalamide - isoselenocyanate — NISC - 6 — to inhibit both the Akt1 pathway and human topoisomerase IIα — topo IIα — activity, which contribute to melanoma tumor growth.

In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole - genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole - genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012).

In 2012, as part of efforts to better understand the causes of melanoma, researchers at the Broad Institute, the Dana - Farber Cancer Institute and a number of other institutes reported the results of whole genome sequencing of 25 human metastatic melanomas (Berger et al., 2012).

The analysis also found that a significant fraction of tumors contained rearrangements and mutations of a gene called PREX2, and experiments confirmed that cancer - associated mutations of PREX2 promoted the growth of human melanoma cells in mice.

Our team was instrumental in the development of talimogene laherparepvec, the first in human oncolytic virus therapy for patients with melanoma.

In 1999, Wolchok received a grant from CRI to conduct a clinical trial of a xenogenic vaccine in humans with melanomIn 1999, Wolchok received a grant from CRI to conduct a clinical trial of a xenogenic vaccine in humans with melanomin humans with melanoma.

Immunological factors in human sarcomas and melanomas: a rational basis for immunotherapy.

Further research uncovered a broad spectrum of cell surface stem cell markers (e.g., CD133, CD44, and CD24) that allow the identification of CSCs in human solid tumors, including brain, breast, prostate, pancreas, liver, ovary, skin, colon cancers, and melanoma (3 - 6)(Figure 1 based on 7).

A dominant negative Cx43 mutant differentially affects tumorigenic and invasive properties in human metastatic melanoma cells.

Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells.

Mucosal melanomas with mutations in CDK4 may respond to palbociclib or ribociclib, which have demonstrated activity in advanced hormone receptor — positive, human epidermal growth factor receptor 2 — negative breast cancer.

Germline mutations of the CDKN2 gene in UK melanoma families, in Human Molecular Genetics.

Published in Human Mutation Fung, D. C.; Holland, E. A.; Becker, T. M.; Hayward, N. K.; Bressac - de Paillerets, B.; Mann, G. J. eMelanoBase: an online locus - specific variant database for familial melanoma Hum Mutat 21 (1): 2 - 7, 2003

Published in Human Molecular Genetics Ghiorzo P, Gargiulo S, Pastorino L, Nasti S, Cusano R, Bruno W, Gliori S, Sertoli MR, Burroni A, Savarino V, Gensini F, Sestini R, Queirolo P, Goldstein AM, Scarrà GB.Impact of E27X, a novel CDKN2A germ line mutation, on p16 and p14ARF expression in Italian melanoma families displaying pancreatic cancer and neuroblastoma Hum Mol Genet.