SSGCID's primary mission is to determine the 3D atomic structures of proteins and other molecules with an important biological role
in human pathogens themselves, or molecules involved in host - pathogen interactions, by applying state - of - the art high - throughput (HTP) technologies and methodologies.
The emergence of antibiotic resistance
in human pathogens has become a major threat to modern medicine and in particular hospitalized patients.
Proteins targeted for structure determination by SSGCID are selected for their biomedical relevance
in human pathogens such as Ebola and Zika, as well as those responsible for tuberculosis, leprosy, malaria, and influenza.
One - hundred - ten of the genes had clear similarities in sequence to known antibiotic - resistance genes, the team discovered, and 18 of those were 100 % identical to genes found
in human pathogens.
Not exact matches
Laurie Garrett, one of the globe's most gifted writers on global public health issues, has a timely and scary essay on foreignpolicy.com about the nasty norovirus plaguing athletes
in the Olympic village — a bug one expert calls the «perfect
human pathogen.»
Species commonly found
in humans: Clostridium perfringens (potential
pathogen), Clostridium difficile (potential
pathogen), Clostridium tetani (potential
pathogen; is only transiently associated with
humans, does not colonize the intestines).
Species commonly found
in humans: Staphylococcus epidermidis, Staphylococcus aureus (potential
pathogen).
Consider Chan Zuckerberg's Biohub, which is embracing big hairy audacious projects like mapping every cell
in the
human body (with university partners Berkeley, Stanford, and UCSF) and developing a «universal diagnostic test» and rapid - response team for emerging
pathogens.
That's why he spent $ 50 million of his own money developing the prototypes and testing them
in Third World villages, and they work, and we have to get the word out because 50 percent of all
human illness is caused by waterborne
pathogens.
The
human biochemical response to
pathogens is linked with avoidance and alarm response mechanisms
in the face of predators and other perceived dangers or stress.
When composting crop residues, manures or other agricultural wastes, it's necessary to achieve temperatures above 131 °F for a defined period of time
in order to kill weed seeds and
human pathogens.
Human milk banks refuse donations from any mother who has had a tattoo done
in the past 12 months due to the risk of blood - born
pathogens, such as hepatitis.
High levels of E. coli are considered an indicator of other
pathogens found
in human and animal waste.
Perhaps the other ingredients
in leachate are toxic enough to kill
human pathogens.
Other references cite that
human milk components are,
in vitro, able to degrade many
pathogens including but not limited to N. gonorrheae, H. influenzae, V. cholera, H. pylori, S. flexneri, and B. pertussis.
Further, there are a great many parasitic forms, including
pathogens in most plants and animals,
humans included.
Some crop — and even
human — diseases might be stopped dead
in their tracks if researchers can harness a new discovery about how
pathogens first infect their hosts
«What has emerged from our study as well as from other work on introgression is that interbreeding with archaic
humans does indeed have functional implications for modern
humans, and that the most obvious consequences have been
in shaping our adaptation to our environment — improving how we resist
pathogens and metabolize novel foods,» Kelso says.
«Norovirus is one of the deadliest
human pathogens that we know the least about,» said first author Craig B. Wilen, MD, PhD, an instructor
in pathology and immunology.
The evolution of the SARS virus — like flu, an RNA virus — is a vivid example of how a
pathogen incubated
in the markets of Guangdong managed to jump species and adapt to
humans.
Transgenic antithrombin was intended to improve supply and address concerns about
pathogens in the form of the drug isolated from
human blood.
Since the beginning of the Industrial Age,
humans have been perturbing the natural world
in ways that bring us closer to the
pathogens that kill us.
The larger lesson is that we are
in a race everywhere to cut off the
pathogen's access to
human victims before it establishes a fast track
in the local populations.
«It is just a range extension of a mosquito that has been shown to possibly be able to vector different
human pathogens that we currently don't have [
in British Columbia],» said Scott McMahon, one of the authors and national operations manager at Culex.
Researchers like Mark Woolhouse, professor of infectious disease epidemiology at the University of Edinburgh
in Scotland, have found at least 868
human pathogens that infect both animals and
humans, although some are not as fearsome as they seem.
New research published
in ASM's Applied and Environmental Microbiology shows that
pathogens can also jump the species barrier to move from
humans to animals.
The boost
in these
human - associated microbes could increase transmission of potential
pathogens and decrease exposure to potentially beneficial environmental microbes.
It should prompt donors and international organizations to ramp up their funding of efforts to control outbreaks of the H5N1 virus
in poultry, and so give the virus fewer opportunities to evolve into a
human pathogen, she says.
In dogs, which have been domesticated for over 17,000 years, there were 71 shared parasites and pathogens, and in the 11,000 year association between humans and cattle, 34 have accumulate
In dogs, which have been domesticated for over 17,000 years, there were 71 shared parasites and
pathogens, and
in the 11,000 year association between humans and cattle, 34 have accumulate
in the 11,000 year association between
humans and cattle, 34 have accumulated.
The newly discovered viruses appeared
in every family or genus of RNA virus associated with vertebrate infection, including those containing
human pathogens such as influenza virus.
Haddow, who studies how
pathogens survive
in the jungle and emerge when
humans encroach, had a great personal interest
in Zika: His grandfather, Alexander Haddow, was one of three scientists who had isolated the virus from a rhesus monkey
in the Zika Forest near Entebbe, Uganda,
in 1947 and described it
in a paper
in 1952.
The findings, reported
in PLOS
Pathogens, are likely to lead to
human clinical trials of the vaccine.
The virus, which looks like a piece of yarn with a slight bend, is the only Ebola
pathogen not known to cause disease
in humans.
A recent study suggests a mystery
pathogen acting
in concert with
human - induced stressors may be the culprits
What we discovered
in Caulobacter also applies to important
human pathogens,» says Jenal.
Studies seeking subtle signs of selection
in the DNA of
humans and other primates have identified dozens of genes,
in particular those involved
in host -
pathogen interactions, reproduction, sensory systems such as olfaction and taste, and more.
«The molecule is essential for growth
in a wide range of bacteria, including many
human pathogens, and we are only
in the early stages of understanding how it controls important processes
in bacteria.»
Jingmenviruses were first described
in 2014 and are related to flaviviruses — a large family of viruses that includes
human pathogens such as yellow fever, West Nile and Japanese encephalitis viruses.
And Alisa «Harley» Newton, a pathologist with the Wildlife Conservation Society, discusses how vets figured out that a
pathogen attacking
humans was
in fact West Nile Virus.
«Despite the relatively low sample size of frozen products
in our study, it is clear that commercial RMBDs may be contaminated with a variety of zoonotic bacterial and parasitic
pathogens that may be a possible source of bacterial infections
in pet animals and if transmitted pose a risk for
human beings,» say the researchers.
Last September Lipkin announced the results of his analysis at a tightly controlled press conference: XMRV was not actually a
human pathogen, he said, confirming an earlier report, but a man - made contaminant unwittingly manufactured
in a lab
in the 1990s.
The data can also reveal when changes
in human conditions — such as improved sanitation — influenced infection rates more than a
pathogen's innate traits.
To do this, the research team enrolled 65 healthy volunteers aged 18 to 50 years
in the
human challenge study — a type of research study
in which individuals are exposed to disease - causing
pathogens under carefully controlled conditions.
«This approach of «xenosurveillance» could detect
pathogens before they spread to
humans, as well as the emergence of new diseases
in wild animals that may threaten their long - term survival.»
Trillions of microbes inhabit the
human body, protecting us from
pathogens and keeping our systems
in tune.
Globalisation has resulted
in the movement of
humans and animals all across the world, bringing
pathogens into contact with hosts that haven't had the opportunity to establish resistance.
«As far as I am aware, this is the first time that researchers have found that an invasive predator (such as the python) has caused an increase
in contact between mosquitoes and hosts of a
human pathogen,» said Nathan Burkett - Cadena, a faculty member with the UF / IFAS Florida Medical Entomology Laboratory
in Vero Beach, Florida.
The KU Leuven team is currently examining whether other
pathogens show a similar increase
in tolerance and whether the same process of genetic adaptation takes place during the treatment of infections
in human beings.
Nobody knows if adding the interleukin - 4 gene would have the same effect
in a different
pathogen, but «the question instantly became what would happen if somebody tried this with smallpox or other
human viruses,» says Seamark.
One of these, Helicobacter pylori, is a
pathogen that can cause stomach ulcers
in humans and is the strongest known risk factor for gastric cancer.