Sentences with phrase «in human pathology»

Behavior analytic theory came to be regarded as too narrow to account for the complexities involved in human pathology.

chondrodysplasia: any growth plate (cartilage) disturbance resulting in canine dwarfism; in human pathology, it has a different meaning: enchondromatosis, a rare disorder marked by enlarged cartilage and tumors in joints.

We explore the relations existing between cysteamine - driven inflammation versus cytoprotection in vivo and in human pathologies.

Not exact matches

Examines the pathology of normalcy in our society and the creation of a society in which human needs will be fulfilled.

Assagioli has an appreciation for the way in which the intensive study of pathology by psychoanalysis and depth psychology has enlarged and deepened our understanding of the human psyche.

The growth contributions of the traditional therapies are, for the most part, concentrated in two areas — their illumination of the depths and complexity of human personality, and their insights about the nature and dynamics of deeply blocked growth (pathology).

He saw human personality in biologically reductionistic, pathology - centered ways.

There are great differences among these three spokes - persons for social possibility and pathology, but they all focus on the fact that societies have ways in which to articulate and distort certain kinds of truth that make human life possible Or problematic.

First of all, it implies some superficial beliefs about the place of sexuality in human experience (we might regard these as being in the antechamber of the temple of sacred sexuality proper): the belief that sexuality is a key, perhaps even the key, component of the quality of being human (in this, of course, lies the pervasive heritage of Freud); the belief that modern Western culture, and especially American culture, has unduly suppressed sexuality (this is the anti-Puritan aspect of the proposition), and, that, as a result, not only are we sexually frustrated (and that frustration carries all sorts of physical and psychological pathologies in its wake), but our entire relation to our own bodies as well as the bodies of others has become distorted.

«Norovirus is one of the deadliest human pathogens that we know the least about,» said first author Craig B. Wilen, MD, PhD, an instructor in pathology and immunology.

«We feel it's critical that the scientific community consider the potential hazards of all off - target mutations caused by CRISPR, including single nucleotide mutations and mutations in non-coding regions of the genome,» says co-author Stephen Tsang, MD, PhD, the Laszlo T. Bito Associate Professor of Ophthalmology and associate professor of pathology and cell biology at Columbia University Medical Center, and in Columbia's Institute of Genomic Medicine and the Institute of Human Nutrition.

«Before this study, it was not known if it is possible to produce sufficient numbers of these cells and successfully use them to remuscularize damaged hearts in a large animal whose heart size and physiology is similar to that of the human heart,» said Dr. Charles Murry, UW professor of pathology and bioengineering, who led the research team that conducted the experiment.

We see parasites and pathologies far more severe than in domestic animals or humans.

If the same dynamic plays out in human brains, hyperconnections in the developing cortex could result in the neural pathologies observed in human autism, Kanold said.

«Every human carries trillions of bacteria in their gut (gut microbiome) and recent advances in research indicate that these tiny passengers play an important role in our overall health maintenance,» says Ashutosh Mangalam, PhD, assistant professor of pathology at the University of Iowa Carver College of Medicine.

In contrast, Neandertals and modern humans share derived wrist morphology that forms during embryogenesis, which diminishes the probability that pathology could result in the normal primitive statIn contrast, Neandertals and modern humans share derived wrist morphology that forms during embryogenesis, which diminishes the probability that pathology could result in the normal primitive statin the normal primitive state.

«The findings underline the therapeutic potential of this endogenous anti-inflammatory factor, Del - 1, in further human pathologies where the levels of Del - 1 are reduced,» Chavakis said.

So you can put all this together and say it's reasonable that some of this is really driving pathologies in humans.

So it is reasonable to say that this is driving pathologies in humans.»

New findings published in Biological Psychiatry brings us closer to understanding the pathology of autism, and the point at which it begins to take shape in the human brain.

Knowledge of these mechanisms in songbird species with different social and mating systems may in turn elucidate social and sexual pathologies in humans.

The study, led by Dr. Maximilian Muenke of the National Human Genome Research Institute in Bethesda, Maryland, brings scientists closer to understanding how ADGRL3 contributes to risk by providing functional evidence that implicates a transcription factor in the pathology of the disorder.

By examining brain regions most affected by Alzheimer's disease pathology in humans, the group demonstrated that amyloid beta plaques and blood vessels were present in all 20 aged chimpanzee brains.

«We think that for the first time, we have a mouse model of anorexia that closely resembles the conditions leading up to the disease in humans,» said study leader Lori Zeltser, PhD, associate professor of pathology & cell biology and a researcher in the Naomi Berrie Diabetes Center.

«Since the pathology that we saw in the mice matches what is seen in humans, we will now explore translating these findings to humans,» Kanneganti said.

«Very few studies have investigated Alzheimer's disease pathology in chimpanzees, the species closest in phylogeny and most genetically related to humans,» said senior author Mary Ann Raghanti, Ph.D., associate professor and interim chair of anthropology at Kent State.

«The presence of amyloid and tau pathology in aged chimpanzees indicates these Alzheimer's disease lesions are not specific to the human brain as generally believed,» Hof continued.

The next step, says Makoto Kuro - o, an assistant professor of pathology at the University of Texas Southwestern Medical Center, is to study Klotho in humans.

The authors also found abnormalities in the subthalamic nucleus occur earlier than in other brain regions, and that subthalamic nucleus nerve cells progressively degenerate as the mice age, mirroring the human pathology of Huntington's disease.

Researchers Bob Hider and S. Singh from the Department of Pharmacy at King's College, London describe the effects and novel chemical treatments of pathology caused by an imbalance of iron in the human body.

Results of previous studies in mice of bexarotene's effect on AD have been mixed, and none of those studies were done in mice that carry a human APOE gene and also develop progressive, AD - like pathology.

«Very few studies have investigated Alzheimer's disease pathology in chimpanzees, the species closest in phylogeny and most genetically related to humans,» said senior author Dr. Mary Ann Raghanti, associate professor and interim chair of anthropology at Kent State.

«It's probably the single most common gene fusion in human cancer,» said study co-leader Antonio Iavarone, MD, professor of neurology and of pathology and cell biology (in the Institute for Cancer Genetics) at CUMC.

The rest of the complex anatomical changes that are observable in human evolution are subsumed under one heading: pathology.

The setting in Honolulu captured my conflicted mood perfectly — human pathology inside the convention center and great natural beauty outside of it.

Rheumatoid arthritis and Spondyloarthritis are accompanied by several comorbid pathologies in human patients, often involving heart, lung and intestinal pathologies.

Human Embryonic Stem (hES) cells derived from Preimplantation Genetic Diagnosed (PGD)- embryos offer a new alternative source of cellular model as they can be largely expanded, differentiated in several cell types and harbors «naturally» the causative mutation of the pathology.

We have found that expression of C3 in normal mouse eyes leads to pathology similar to AMD in humans, including the creation of anaphylatoxins and the MAC.

Monogenic diseases are often lacking of physiological human cellular models dedicated to the study of the molecular mechanism implicated in the development of the pathology.

The unit study macromolecules that are central in basic processes of cellular life, as well as for specific human pathologies.

In the April 13, 2007, issue of Science, the research team — led by James C. Lo, an MD, PhD student, in the laboratory of Yang - Xin Fu, MD, PhD, professor of pathology at the University of Chicago — suggest that an engineered protein could keep mice, and possibly humans, from developing high cholesterol and triglyceride levels, a key risk factor for coronary heart diseasIn the April 13, 2007, issue of Science, the research team — led by James C. Lo, an MD, PhD student, in the laboratory of Yang - Xin Fu, MD, PhD, professor of pathology at the University of Chicago — suggest that an engineered protein could keep mice, and possibly humans, from developing high cholesterol and triglyceride levels, a key risk factor for coronary heart diseasin the laboratory of Yang - Xin Fu, MD, PhD, professor of pathology at the University of Chicago — suggest that an engineered protein could keep mice, and possibly humans, from developing high cholesterol and triglyceride levels, a key risk factor for coronary heart disease.

Specific Aim 2: Having utilized mutant mice to identify the key players in AMD pathology from Specific Aim 1, we will develop and test molecules that target either the anaphylatoxins or the MAC, or both, in the context of practical therapies that can be utilized in humans.

Recently, loss - and gain - of - function mutations in K2P channels have been directly linked to human pathologies (Birk Barel syndrome, familial migraine with aura, cardiac conduction disorder).

Tissue - clearing protocols are causing a revolution in human brain pathology.

In this study, we have used a multidimensional approach including high - magnification and super-resolution microscopy, cerebro - spinal fluid (CSF) mass spectrometry analysis and ELISA to investigate the Aβ pathology and its associated cognitive impairments, in a novel transgenic rat model overexpressing human APIn this study, we have used a multidimensional approach including high - magnification and super-resolution microscopy, cerebro - spinal fluid (CSF) mass spectrometry analysis and ELISA to investigate the Aβ pathology and its associated cognitive impairments, in a novel transgenic rat model overexpressing human APin a novel transgenic rat model overexpressing human APP.

The reason for the lack of translation may be that many of these compounds are only effective when administered before pathology is present; yet, in humans, pathology is usually quite advanced at diagnosis and treatment.

This was then subjected to initial testing for immunological efficacy in mThy1 - AS mice, which overexpress WT human AS under the murine Thy1 promoter, and which exhibit sensorimotor behavioral deficits, axonal AS pathology, and C - terminally - truncated AS aggregates with regional distribution similar to PD and PD dementia (PDD).

The idea that only APP accumulates intraneuronally is thought - provoking and additionally, whether the intracellular Aβ pathology causes some of the symptoms in human AD remains unknown.

Tg5453 is a transgenic mouse with transmembrane human TNF deregulated expression resulting in the spontaneous development of arthritis whose pathology closely resembles human rheumatoid arthritis.

Biomedcode's unique animal models of human TNF - depended arthritis have offered the first proof of concept for the central role of TNF in the development of human pathology.