Sentences with phrase «in human patients who»

Mice that underwent this procedure developed eye problems like those seen in human patients who have Graves» disease, while the control group of mice did not develop these complications.

Not exact matches

In 2000, Medarex began its first phase of human testing on its new «CTLA -4-blockade» — in patients who had either prostate cancer or metastatic melanoma, a deadly form of skin canceIn 2000, Medarex began its first phase of human testing on its new «CTLA -4-blockade» — in patients who had either prostate cancer or metastatic melanoma, a deadly form of skin cancein patients who had either prostate cancer or metastatic melanoma, a deadly form of skin cancer.

A general summary was provided by ethics experts who testified before then - Congressman Albert Gore's Committee on Science and Technology in 1982: (1) Though risks in experimentation are inevitable, a strong bias toward the sacredness of human life requires the highest regard for the patient or subject.

This goes to the heart of purpose of human creation, Allah says that humans will be tested through losing their wealth and loved ones and personal sufferings in the same way when they are tested by having wealth and children's so we can see who was the most patient and righteous at the end so let's not blame God for all evils a human being is able to commit.

Pregnancy derived from Human Zygote Pronuclear transfer in a patient who had arrested embryos after IVF

When the researchers gave concentrated broccoli sprout extracts to 97 human type 2 diabetes patients in a 12 - week randomized placebo - controlled trial, obese participants who entered the study with dysregulated disease demonstrated significantly decreased fasting blood glucose levels compared to controls.

«I'm working with Professor Richard Oreffo and Dr Rahul Tare from the University's Centre for Human Development, Stem Cells and Regeneration who are trying to create and grow cartilage in the lab using a patients» own (autologous) stem cells to then be implanted back into the patient if they have a cartilage defect,» she explains.

«If this technology can be scaled to human - size grafts, patients suffering from renal failure, who are currently waiting for donor kidneys, could theoretically receive an organ grown on demand,» says Harald Ott, head of the team that developed the rat kidneys at the Massachusetts General Hospital in Boston.

GTC recognized the need to demonstrate on its own the potential for the technology and, in the late 1990s, began a clinical trial of human antithrombin for patients undergoing bypass surgery who develop resistance to the anticoagulant drug heparin.

«With more than 100 genes already known to cause deafness in humans, there are many patients who may eventually benefit from this technology.»

«If this approach works in humans, it will really change the conversation that providers have with patients,» Scadden said, especially for those «who have these underlying genetic disorders and for who the new gene - editing and gene therapy techniques are being developed.»

Woo Suk Hwang, the veterinarian who made headlines when he cloned human stem cells last year, announced in May that he and his colleagues had made stem cells tailored for different patients.

In 2017, they'll try the device on human participants — paralyzed patients who will use stentrodes to control mechanical exoskeletons.

They have tested the system — which could also help patients who suffer from severe epileptic seizures — in rats and are now planning to begin human trials.

In the new study, to test whether the same observation was true in humans, Dr. Rostami and colleagues tested blood samples of patients with MS who had not yet received therapy, and those currently being treated with INF - β, a commonly used therapIn the new study, to test whether the same observation was true in humans, Dr. Rostami and colleagues tested blood samples of patients with MS who had not yet received therapy, and those currently being treated with INF - β, a commonly used therapin humans, Dr. Rostami and colleagues tested blood samples of patients with MS who had not yet received therapy, and those currently being treated with INF - β, a commonly used therapy.

«However, given that IGF - 1 is approved for human use in people who are deficient in this hormone, a clinical trial of IGF - 1 in lithium - resistant bipolar disorder patients is warranted.»

The researchers next will turn to analyzing the presence of myoferlin in samples from numerous human tumor types available in an Ohio State tissue bank, which will allow them to compare protein levels in tumors to clinical outcomes for the patients who provided the samples.

«I knew of an experimental technique that had not yet been done in humans, and I had a patient with no other options who was failing rapidly,» says William O'Neill, M.D., medical director of the Center for Structural Heart Disease at Henry Ford Hospital.

The authors observed an inflammatory response in two patients who had mutated versions of SKIV2L, suggesting that SKIV2L keeps inflammation in check in human cells, too.

«We are in an era where the primary issues are not federal funding for human embryonic stem cell research,» wrote CAMR President Amy Comstock Rick, who is also CEO of the Parkinson's Action Network, in an e-mail to the more than 100 patient advocacy, scientific, and other groups that belong to CAMR.

«The primary mission of the USC Neurorestoration Center is to take advantage of resources from our clinical programs to create unique opportunities to translate scientific discoveries, such as those of the Andersen Lab at Caltech, to human patients, ultimately turning transformative discoveries into effective therapies,» says center director Charles Y. Liu, professor of neurological surgery, neurology, and biomedical engineering at USC, who led the surgical implant procedure and the USC / Rancho Los Amigos team in the collaboration.

More animal studies would be needed to move this drug toward human clinical trials, but «what we hope is that we could use this drug to intervene in patients who have had an episode of prolonged seizures and give it to them briefly following that episode to protect them from becoming epileptic,» said James McNamara, M.D., a professor in the departments of neurobiology and neurology at Duke University.

In the new work, the researchers added serum from Finnish narcolepsy patients who had received Pandemrix to cells that were engineered to display human hypo cretin receptor 2 on their surface.

«Liver cancer is on the rise worldwide, and in human studies we've now seen that patients can progress from fatty liver disease to liver cancer without any middle steps such as cirrhosis,» says David Moore, a professor of molecular and cellular biology, who led the study with Associate Professor Loning Fu, both at Baylor.

In the current study, the researchers report the success of the BASILICA procedure in seven gravely ill patients who qualified for compassionate use of the technique — then untested in humans — because no other care options were availablIn the current study, the researchers report the success of the BASILICA procedure in seven gravely ill patients who qualified for compassionate use of the technique — then untested in humans — because no other care options were availablin seven gravely ill patients who qualified for compassionate use of the technique — then untested in humans — because no other care options were availablin humans — because no other care options were available.

«We are now in a position to be able to generate patient - and disease - specific stem cells, without using human eggs or embryos,» says Shinya Yamanaka of the University of Kyoto, who led the Japanese team.

«It is exciting that they have generated human cells from the patient material,» says stem cell researcher Jeffrey Rothstein of Johns Hopkins University in Baltimore, Maryland, who also studies ALS.

In the first published results from a clinical trial using human embryonic stem cells, two legally blind patients who received an injection of hESC - derived cells in one eye have experienced no harmful side effects and appear to have slightly better visioIn the first published results from a clinical trial using human embryonic stem cells, two legally blind patients who received an injection of hESC - derived cells in one eye have experienced no harmful side effects and appear to have slightly better visioin one eye have experienced no harmful side effects and appear to have slightly better vision.

The mice show many of the symptoms that human patients do, and so they were an especially good candidate to test iPS cells» abilities, says stem cell researcher Rudolf Jaenisch of the Whitehead Institute for Biomedical Research and the Massachusetts Institute of Technology, both in Cambridge, who collaborated with Townes on the project.

Scientists report in the May 9 Science Translational Medicine that seven of 12 diabetic mice treated with this combination were cured even after having lost the ability to make insulin for several weeks, the equivalent of a human patient who has needed insulin injections for a couple of years.

Geron became the first company to start clinical trials of embryonic stem cells in humans, starting with a patient who had spinal cord injuries.

Of the 22 patients whose tumors successfully grafted, six died before data from the mice were available, but in 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsIn a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin cases where genetic sequencing of the tumor showed no actionable mutations.3

They then examined the effect of a chemical that inhibits SRF and found that glucose uptake rates increased in both mice and human cells — and that the effects were greater in cells from patients who were insulin resistant or had type 2 diabetes.

September 17, 2009 The Maria and Sam Miller Professional Excellence Awards presented to Dr. Eng for scientific achievement in clinical research This award is presented to a scientist or physician who has made significant contributions to clinical science by conducting human subject research that directly affects the outcome of patient care and brings basic science to the bedside.

«Our approach allowed us to grow human neurons in a dish that contained the exact same mutation as the neurons in the brain of the patient,» explained first author Helen Fong, PhD, who is also a California Institute for Regenerative Medicine postdoctoral scholar.

The aim of this clinical trial is to replicate in humans the same results observed in mice and, ultimately, lead to an effective, nontoxic treatment for newly diagnosed patients as well as patients who can no longer benefit from conventional treatments.

«This is hard to do in a standard human clinical study where one compares patients with a history of smoking versus those who do not smoke because all of the patients have different histories, backgrounds and patterns of exposure to the stimulus.»

Spurred by this finding, Littman's team examined the gut microbiota in patients with rheumatoid arthritis, a debilitating autoimmune disease, and found a much higher proportion of patients than healthy individuals who harbored the human intestinal bacterium Prevotella copri.

Bringing on Rajkovic is a key step in hastening access to the benefits of precision medicine for UCSF Health patients, said Institute for Human Genetics director Neil Risch, PhD, who co-chaired the search committee with Norton.

«Although FTD and NCL patients differ markedly in age and clinical manifestations, we wanted to know if humans who carry FTD - related genetic mutations in progranulin share features with NCL patients,» said Li Gan, PhD, associate director of the Gladstone Institute of Neurological Disease and professor of neurology at UCSF.

The team of researchers harvested hematopoietic stem cells from three macaques prior to SHIV infection of all six animals in the study, treated the animals with anti-retroviral therapy (ART) to reduce viral load and mimic the situation in human HIV - infected patients who are treated with ART, and then exposed the three monkeys from which they had collected hematopoietic stem cells to a high dose of radiation.

I think we all agree that we over treat prostate cancer in this country compared to what you see in Europe with similar outcomes and so but I think this is where the human or the Cancer Genome Project or at least better biomarkers for looking at mutations that we already know occur in these diseases I think hopefully within the next few years every single patient who is diagnosed with prostate cancer those biopsies will be characterized and then the patients followed, hopefully watchful waiting and we'll ultimately get a correlation between what mutational events predict a rather dormant disease as opposed to a very aggressive disease.

These kind of mice are an extraordinary resource for modeling human disease; for instance, research has found that mice that are genetically mutated to carry the BRCA1 gene (a human breast cancer gene) behave more similarly to human cancer patients than those mice who have had a tumor physically transplanted in.

These results, also presented at the 2015 European Cancer Congress (ECC2015, abstract # 5BA) today, which involve the group of 1,626 patients with a Recurrence Score between 0 and 10, demonstrated that 99.3 percent of node - negative, estrogen receptor (ER)- positive, human epidermal growth factor receptor 2 (HER2)- negative patients who met accepted guidelines for recommending chemotherapy in addition to hormonal therapy, had no distant recurrence at five years after treatment with hormonal therapy alone.

Dr. Cornelius Moerman was a country medical doctor in Holland who fine - tuned his diet over many years by treating both pigeons and then human patients who voluntarily went through his treatment plans.

* In two human clinical studies, patients who supplemented with Algas calcareas, the main component of Osteo Pro Rx, along with proper diet and exercise, increased bone mineral density up to 4.33 % in just one yeaIn two human clinical studies, patients who supplemented with Algas calcareas, the main component of Osteo Pro Rx, along with proper diet and exercise, increased bone mineral density up to 4.33 % in just one yeain just one year.

The use of HGH or Human Growth Hormone is growing in popularity among anti aging medical professionals or age management physicians, to aid their patients in enhancing their overall well - being and to help those who are suffering from a hormonal imbalance, or Andropause (the male menopause).

Following a single father who works as a human billboard in Taipei, and his left - to - their - own - devices kids, with the presence of their mother represented by three different actresses, the film has the barest thread of story (Tsai has admitted that he no longer has any real interest in narrative), and seems determined to provoke less patient audience members into walking out, with a series of shots that last upwards of ten minutes without all that much movement in them.

Like doctors who have been using VR to assist in surgeries and pinpoint ailments — by generating 3D models of real patient tumors from MRI scans, for example — science teachers are saying VR can help deepen understanding of subjects such as biology and anatomy, which require students to grasp the inner workings of cells and organs that are not visible to the human eye.

When their owners came on service, Brandi and Eddie, who were 90 years old in human years, were enrolled in Pet Peace of Mind (PPOM), a program created by HGC in 2007 to take care of the pets of patients when they are no longer able.