Sentences with phrase «in human patients with»

This virus is currently being evaluated in human patients with liver cancer in an FDA - approved trial.

Similar studies in human patients with pancreatitis have failed to document a benefit of FFP use.

The clinical impression in dogs and cats that powder is more effective than tablets, capsules, and especially enteric - coated products has also been substantiated in human patients with EPI.

However, the use of omeprazole has recently been shown to be efficacious in human patients with EPI and may be tried if the patient does not respond to routine therapy.

With its internationally renowned school of veterinary medicine and its NCI - designated human cancer center, UC Davis is uniquely positioned to evaluate novel treatments for companion dogs with spontaneous tumors that may ultimately be effective in human patients with cancer.

«I was really excited to hear about their work because the cat disease behaved very similarly to what I saw in my human patients with oral lichen planus,» Fazel said.

One of the results of this collaboration is that we were able to take a basic science finding from Andrew Huberman's lab that certain layers in the retina are affected early in glaucoma — and we're immediately able to develop engineering approaches to see some of those changes in human patients with glaucoma.

The changes also resemble those found in human patients with hippocampal damage.

A phase - 1 clinical trial of the drug in human patients with pulmonary hypertension is expected to begin this winter.

Next, they did a very clever experiment, which was to measure the length of the CAG repeat length in the ataxin - 2 gene in human patients with ALS.

Despite overexpression of mRNA from the XpdTTD allele relative to the wt allele (Figure 1E), TFIIH protein levels were reduced by 50 % in primary mouse XpdTTD / TTD fibroblasts (Figure 4E and 4F), thereby mimicking the situation in human patients with TTD.

Even in human patients with peripheral obstructive artery disease, detailed diagnostic images revealed that the inferior gluteal artery expands in response to vascular stenosis (vessel hardening).

Because myostatin normally acts to limit muscle growth, there has been considerable interest in targeting this pathway to attempt to enhance muscle growth in human patients with muscle wasting and muscle degenerative diseases.

The next step was to find out which role Shp2 and its target genes play in human patients with breast cancer.

Now researchers have achieved success in human patients with a ruse that turns the immune system against these growths.

Identical findings were seen in human patients with traumatic complete spinal cord injury, researchers wrote.

This suggests that inhibiting MMP - 9 in human patients with ALS should be beneficial.

For example, although early clinical trials of Listeria - based vaccines have shown that the neutralized bacterium produces only mild flulike symptoms in human patients with cervical cancer, the various methods of genetically disarming the bacteria should be explored to find the safest approach for people gravely ill with pancreatic cancer, because these patients are likely to already have weak immune systems.

«Once we've shown that this can safely be used in human patients with pulmonary hypertension — and we've got a clinical trial in progress right now — we'll be able to conduct studies of inhaled NO delivered in ambulatory settings, including patients» homes, to treat chronic pulmonary hypertension, right - sided heart failure and chronic obstructive pulmonary disease.»

Those false lines were used in the early trials of two drugs that were later tested in human patients with thyroid cancer.

Intentional Warfarin Overdose in a Human Patient With Liver Disease and Concurrent Pulmonary Emboli

Intriguingly, an identical homozygous mutation was identified in a human patient with recessive retinitis pigmentosa, the human equivalent of PRA, and established the novel retinal gene, PRCD, as an important gene for the maintenance of rod photoreceptor structure and function across species.

Not exact matches

Sequencing in one 18 - year - old patient found several oncogenes, and her and her family will continue to work with Human Longevity to monitor the cells.

«We're revolutionizing human hair transplantation using sophisticated robotics and we needed a patient investment partner with a solid track record in medical devices — so we turned to InterWest.

Since the human genome was decoded in 2003, researchers have been developing a powerful method for comparing the genomes of patients and healthy people, with the hope of pinpointing the DNA changes responsible for common diseases.

This is done routinely in experiments with animals and occasionally with human patients undergoing neurological treatment.

With regard to Callahan's comparison of the lives of PVS patients with the lives of «fertilized eggs,» I would simply note that once an egg has been fertilized it is no longer an egg but a new living being, and in the case of the human species, a new human being — surely a being of incomparably greater value than an «egg.&raWith regard to Callahan's comparison of the lives of PVS patients with the lives of «fertilized eggs,» I would simply note that once an egg has been fertilized it is no longer an egg but a new living being, and in the case of the human species, a new human being — surely a being of incomparably greater value than an «egg.&rawith the lives of «fertilized eggs,» I would simply note that once an egg has been fertilized it is no longer an egg but a new living being, and in the case of the human species, a new human being — surely a being of incomparably greater value than an «egg.»

When this belief was coupled with the notion of a last judgement which would not occur until God «had accomplished the number of his elect», in words from still another prayer, it said something about the corporate nature of human life, the equally corporate nature of whatever destiny men have, and the need for patient waiting until our fellowmen have found their capacity for fulfillment along with us.

In spite of his fascination with theory, Jung observed: «It is a remarkable thing about psychotherapy: you... can cure only from one central point; that consists in understanding the patient as a psychological whole and approaching him as a human being, leaving aside all theory and listening attentively to whatever he has to say.&raquIn spite of his fascination with theory, Jung observed: «It is a remarkable thing about psychotherapy: you... can cure only from one central point; that consists in understanding the patient as a psychological whole and approaching him as a human being, leaving aside all theory and listening attentively to whatever he has to say.&raquin understanding the patient as a psychological whole and approaching him as a human being, leaving aside all theory and listening attentively to whatever he has to say.»

Judge Miner, writing for the majority in the Second Circuit, asked: «What concern prompts the state to interfere with a mentally competent patient's «right to define [his] own concept of existence, of meaning, of the universe, and of the mystery of human life,» when the patient seeks to have drugs prescribed to end life during the final stages of a terminal illness?»

«Thus, also in our century, the Lord, the Holy Spirit, has given us new initiatives with new aspects of Christian life: On being lived by human persons with th ``... If the movements are really gifts of the Holy Spirit, they integrate and serve the Church, and in the patient dialogue between pastors and movements a fruitful form is born, in which these elements become edifying elements for the Church of today and tomorrow

Although more and more human studies are being conducted to validate claims found in animals, many studies are with patients with a certain illness or condition (ex.

Before joining local government, he worked for a decade in human services, including counseling HIV and AIDS patients, and those with drug and alcohol issues.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

They may have done a thesis with a translational focus, but few will have received training in the requirements for doing modern patient - oriented research, which includes large doses of epidemiology, statistics, and human - subject trial design.

The UI study, which was published March 28 online in the journal Molecular Psychiatry, adds to the accumulating evidence, including recent human studies from Harvard University, that suggests cerebellar stimulation might help improve cognitive problems in patients with schizophrenia.

By correlating osteoarthritis in living birds with their known behaviors, Rothschild hopes to learn more about the causal factors than he ever could from his human patients.

When the researchers gave concentrated broccoli sprout extracts to 97 human type 2 diabetes patients in a 12 - week randomized placebo - controlled trial, obese participants who entered the study with dysregulated disease demonstrated significantly decreased fasting blood glucose levels compared to controls.

«Acute repeated spikes in blood sugar that you see with each dose of this drug have long - term impacts — and can predispose patients to the development of insulin - resistance Type 2 diabetes and cardiovascular disease,» said David Wright, associate professor in the Department of Human Health and Nutritional Sciences and corresponding author of the paper.

At much higher doses, benzodiazepines treat epilepsy and anxiety in human patients now, including those with autism.

Researchers compared how well IDx - DR detected diabetic retinopathy in more than 800 U.S. patients with diagnoses made by three human specialists.

«I'm working with Professor Richard Oreffo and Dr Rahul Tare from the University's Centre for Human Development, Stem Cells and Regeneration who are trying to create and grow cartilage in the lab using a patients» own (autologous) stem cells to then be implanted back into the patient if they have a cartilage defect,» she explains.

A recent study published in Annals of Neurology reports that healthy human tissue grafted to the brains of patients with Huntington's disease in the hopes of treating the neurological disorder also developed signs of the illness, several years after the graft.

If the procedure works in humans, it would enable donated livers from humans, and possibly even from pigs, to be re-coated with a patient's own cells, reducing the likelihood of organ rejection.

He says his team is so confident with its results that it plans to petition the Food and Drug Administration this fall to test isradipine's effectiveness in human Parkinson's patients, because the drug has already been approved for human use.

The Jarvik - 7, in contrast, was deaf to the song of human experience; built to invigorate its patient, it instead alienated him, supplying Schroeder with everything but the will to live.

And in the United States, the National Human Genome Research Institute in Bethesda, Maryland, recently funded three Mendelian Disorders Sequencing Centers that will apply genome sequencing to diagnosing thousands of patients with a wider range of rare diseases, including intellectual disability and developmental delay.

«Data from this study serves as rationale to now include dogs with spontaneous cancers in the advancement and optimization of PMed for human patients,» according to the study, Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials.

Bolton combined these human hearing models with model checking (an automated, computational approach for finding problems in complex systems) to assess masking in a common patient - monitoring device with six different alarms.

Although the Harvard criteria were based on zero patients and no experiments were conducted either with humans or animals, they soon became the standard for declaring people dead in several states, and in 1981, the Uniform Determination of Death Act (UDDA) was sanctioned by the National Conference of Commissioners on Uniform State Laws.