Sentences with phrase «in human prostate cancer»

A bioengineered microenvironment to quantitatively measure the tumorigenic properties of cancer - associated fibroblasts in human prostate cancer.

Androgen - regulated expression of arginase 1, arginase 2 and interleukin - 8 in human prostate cancer.

Development of a bioengineered model to quantitatively measure the tumorigenic properties of cancer - associated fibroblasts in human prostate cancer.

11C - sarcosine also produced high - contrast images in a human prostate cancer case.

The researchers showed that cabazitaxel worked better than docetaxel in human prostate cancer cells lines that were resistant hormone treatment, both in terms of slowing cancer - cell growth and in its ability to kill cancer cells.

The researchers have yet to show the same pathway is active in human prostate cancers.

Although persistent loss of IGF - 1R expression ultimately induced cell stasis and death, both of these processes are regulated by the tumor suppressor gene p53 that is commonly mutated in human prostate cancers.

Not exact matches

In 2000, Medarex began its first phase of human testing on its new «CTLA -4-blockade» — in patients who had either prostate cancer or metastatic melanoma, a deadly form of skin canceIn 2000, Medarex began its first phase of human testing on its new «CTLA -4-blockade» — in patients who had either prostate cancer or metastatic melanoma, a deadly form of skin cancein patients who had either prostate cancer or metastatic melanoma, a deadly form of skin cancer.

«Very low doses [of BPA]-- below the amounts that are present in humans — when, particularly, exposure occurs in fetuses and newborns, you end up with those babies eventually developing prostate cancer, breast cancer.

Introducing human prostate cancer cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade of signals that made it easier for tumor cells to invade and grow in bone.

Classified as a known human carcinogen, it is linked to lung, kidney and prostate cancer in workers.

In their latest study, they tested compounds against cells from nine different types of human cancer, including common types affecting blood, colon, breast, prostate, ovaries, kidneys, and lungs.

FRESH insight into prostate cancer has come in a study showing that the mitochondrial DNA of human prostate cancer cells is riddled with mutations.

Mutations in mitochondrial DNA have been linked to development of the cancer, so Anita Kloss - Brandstätter of Innsbruck Medical University in Austria and colleagues compared the entire mitochondrial genome of cancerous and non-cancerous tissue from 30 men with prostate cancer (The American Journal of Human Genetics, DOI: 10.1016 / j.ajhg.2010.11.001).

Beyond lung cancer, TiY is able to target TICs in 28 types of human cell lines derived from the central nervous system, melanoma, breast, renal, ovarian, colon, and prostate cancer.

The discovery sheds new light on our understanding of the genetic complexity underpinning variations in human pigmentation, and could advance our knowledge of conditions linked to pigmentation, such as skin, testicular, prostate and ovarian cancers.

By producing the metabolite 2 - phosphoglycerate, PGAM1 regulates several different metabolic pathways, and the levels of this enzyme are abnormally elevated in various human cancers, including breast cancer, lung cancer, and prostate cancer.

A team of researchers in Germany and Denmark led by Steven Johnsen, Professor at the University Medical Center Göttingen, Germany, used human prostate cancer cell lines and depleted them of the DNA - binding protein CHD1.

According to McCague, «the rarity of human prostate cancer cell cultures makes studying tamandron's potential difficult in the test tube.»

This is a neat solution: blocking the uptake of a nutrient needed by prostate cancer cells with nutrients that are commonly in the human diet.

They also tested other cancer lines — human cervical, lung and prostate cancers — and found that they responded to the patterned tumor environments in the same way.

Next, the researchers tested the effects of RK - 33 and radiation in mice that had been injected with human prostate cancer cells that highly express DDX3.

In preclinical experiments using human prostate cancer cell lines, Fu's team showed that increased PLK1 expression activated an oncogene known as c - RAF, which has previously been shown to play a role in regulating cell growth and divisioIn preclinical experiments using human prostate cancer cell lines, Fu's team showed that increased PLK1 expression activated an oncogene known as c - RAF, which has previously been shown to play a role in regulating cell growth and divisioin regulating cell growth and division.

«BPA increases risk of cancer in human prostate tissue, study shows.»

«We found that a comprehensive exercise and diet program in a group setting can make a difference for prostate cancer patients, and the difference was greater than I expected in a short period of time,» said lead author Brian Focht, a professor of human sciences at Ohio State.

«Since the growth of testosterone therapy is relatively recent and prostate cancer is a slow - moving disease, there are at present no data to determine if testosterone could heighten the risk of prostate cancer in humans,» Bosland said.

«Our research provides the first direct evidence that exposure to BPA during development, at the levels we see in our day - to - day lives, increases the risk for prostate cancer in human prostate tissue,» Prins said.

Signs of cancer developed in the human prostate tissue in a third of the mice fed BPA, as compared to only 12 percent in mice that had not been fed BPA.

Early exposure to BPA (bisphenol A)-- an additive commonly found in plastic water bottles and soup can liners — causes an increased cancer risk in an animal model of human prostate cancer, according to University of Illinois at Chicago researcher Gail Prins.

In both laboratory dishes and mice with human prostate cancers, the nanoparticles proved extremely effective.

Tadashi Matsuda of Hokkaido University and his colleagues in Japan investigated human prostate cancer cells to determine if there is an unknown up - regulation mechanism in the EGFR pathway.

Their preliminary findings indicate that MUS81 - induced movement of DNA to the cytosol also occurs in human cancer cells, including prostate cancer, breast cancer, colorectal cancer, uterine cancer, leukemia, and melanoma cells.

The goal of the first experiment was to see whether lncRNAs are differentially expressed in prostate cancer by measuring total RNA from prostate cancer cell lines and normal epithelial prostatic cells using NCode human ncRNA array and SurePrint G3 human lncRNA microarrays.

The DNA of BKV has been discovered in several types of human cancers including prostate tumours, and mouse studies suggest the virus can trigger cancer.

The study compared the effectiveness of the new tracer with 11C - choline (already widely used for imaging prostate cancer) in two mouse models and also performed the first PET / CT scan with 11C - sarcosine of a human with prostate cancer.

For the time course study, cells were treated with 20 μM of EGCG for 12, 24, 48, 72, or 144 h. Human colon cancer cell line HT - 29 and prostate cancer cell line PC3 were obtained from American Type Culture Collection (Manassas, VA), and were grown in McCoy's 5A and RPMI 1640 containing 10 % fetal bovine serum, respectively.

In the test tube, the nanogenerators killed leukaemia, lymphoma, breast, ovarian, neuroblastoma, and prostate human cancer cells.

Reykjavik, ICELAND, 25 September 2011 — Scientists at deCODE Genetics and academic collaborators from Iceland, The Netherlands, Spain, Denmark, Germany, Sweden, the USA, the UK and Romania today report the discovery of a variant in the sequence of the human genome associated with risk of developing basal cell carcinoma of the skin (BCC), as well as prostate cancer and glioma, the most serious form of brain cancer.

Furthermore, we have validated and extended the conclusions of our model system with a detailed analysis of Î ± 2 integrin gene expression and its significance in human breast and prostate cancer.

Interactions between human osteoblasts and prostate cancer cells in a novel 3D in vitro model.

Further research uncovered a broad spectrum of cell surface stem cell markers (e.g., CD133, CD44, and CD24) that allow the identification of CSCs in human solid tumors, including brain, breast, prostate, pancreas, liver, ovary, skin, colon cancers, and melanoma (3 - 6)(Figure 1 based on 7).

The Carboxyl Tail of Connexin32 Regulates Gap Junction Assembly in Human Prostate and Pancreatic Cancer Cells.

Species - specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone.

Previous studies have implicated FOXM1, which encodes a transcription factor protein capable of regulating the activity of many other genes, in many other human cancers, including liver, breast, lung, prostate, colon, and pancreatic cancers.

Reporting the first association between genetic variants in the human steroid 5a - reductase type II (encoded by the SRD5A2 gene) and prostate cancer in 1999.

He also discovered common somatic mutations in prostate cancer in the human steroid 5a - reductase type II (SRD5A2) gene in 2004.

the HGM 2012 (Human Genome Meeting 2012 in Sydney; Australia) and a series of PacRim Breast and Prostate Cancer Meetings in 3 different countries, he was a visiting professor at many universities, incl.

SEATTLE — An imaging agent discovered by a Washington State University researcher that homes in on prostate cancer will be developed for human clinical trials thanks to a two - year $ 2 million federal Small Business Innovation Research grant.

Production of CCS1477 in capsule form is now complete, ahead of forthcoming first - in - human clinical trials to investigate the novel drug's tolerability and efficacy in treating late stage prostate cancer (CRPC).

In a series of lab experiments with cell lines, human xenograft tumors in mice and primary human prostate cancer samples, the researchers demonstrated that miR - 34a inhibits prostate cancer stem cells by suppressing CD4In a series of lab experiments with cell lines, human xenograft tumors in mice and primary human prostate cancer samples, the researchers demonstrated that miR - 34a inhibits prostate cancer stem cells by suppressing CD4in mice and primary human prostate cancer samples, the researchers demonstrated that miR - 34a inhibits prostate cancer stem cells by suppressing CD44.