Now, researchers from the Department of Chemistry at Imperial College London have come up with a system that is specific, flexible, and can detect single protein biomarkers
directly in human serum (a pool of fluid separated from blood).
The researchers found that resistin, an immune protein commonly
found in human serum, instigates an inappropriate inflammatory response to worm infections, impairing the clearance of the worm.
Dr. Bovenkamp conducted further research at the Johns Hopkins University Bayview Proteomics Center in the Division of Cardiology at Johns Hopkins School of Medicine in Baltimore, Maryland, using proteomic techniques for biomarker
detection in human serum.
Bacterial endotoxin
activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation.
What is perhaps most notable in the study by Liu et al (36) was that human monocytes,
in human serum, exhibited biologically important differences in microbicidal response within the range of serum 25 (OH) D values commonly found in free - living populations.