Sentences with phrase «in human stem cells»

Only a few laboratories in the world are attempting this technique in human stem cell research and, thus far, no human stem cell lines have been derived using this method.

These go to researchers trying to advance the field by tackling significant, unresolved issues in human stem cell biology.

The study results were found using mouse embryonic stem cells, which are good cell models for the study of processes seen in human stem cells.

At any given time, more than two - thirds of the DNA in the human stem cells the researchers used is packaged in this way.

The study marked the first time the procedure worked successfully in human stem cells, though it is routinely used in mice.

Home - Salk News - Editing scrambled genes in human stem cells may help realize the promise of combined stem cell - gene therapy

Also playing a key role was Karun Singh, a co-author in the study and holder of the David Braley Chair in Human Stem Cell Research.

A team of researchers at the Stanford University School of Medicine has used a gene - editing tool known as CRISPR to repair the gene that causes sickle cell disease in human stem cells, which they say is a key step toward developing a gene therapy for the disorder.

In this way, they have managed to reproduce chromosomal translocations in human stem cells from blood and mesenchymal tissue that are identical to those observed in patients with acute myeloid leukemia (a blood and bone marrow cancer) or Ewing's sarcoma (a type of bone tumour that affects children and teenagers).

He holds the Canada Research Chair in Human Stem Cell Biology and is a professor in the Department of Biochemistry and Biomedical Sciences of the Michael G. DeGroote School of Medicine.

Recent research by neuroscientist Fred Gage and colleagues at the University of California (UC), San Diego, has shown that one of the most common types of jumping gene in people, called L1, is particularly abundant in human stem cells in the brain that ultimately differentiate into neurons and plays an important role in regulating neuronal development and proliferation.

In fact, in an assessment earlier this year, Cambridge researchers Professor Roger Pedersen and PhD student Victoria Mascetti concluded that the existence of naive human stem cells required confirmation by other stem cell research groups: «Like Higgs» Boson to the field of particle physics,» they explained, naivety in human stem cells «was predicted from considerations of symmetry and conservation, [but] we are yet to unlock its potential.»

«This, when combined with the development of efficient and safe gene editing technologies in human stem cells may greatly help the realization of these expectations.»

In a study published in February online editions of the journal Developmental Biology, Morgridge scientists tested the stringency of the developmental clock in human stem cells during neural differentiation.

Endocytosis in a human stem cell derived organoid.

National Bioethics Advisory Commission, «Ethical Issues in Human Stem Cell Research,» Rockville, Md.: National Bioethics Advisory Commission, 1999: iv - v.

In 2013, in the journal Science, a team led by her and bioengineer Prashant Mali, now at the University of California, San Diego, stunned the scientific world by reporting CRISPR gene editing in human stem cells.

To do this, they created a cellular model of Werner syndrome by using a cutting - edge gene - editing technology to delete WRN gene in human stem cells.

But even though doctors and scientists have long studied the often devastating disorders caused by these tiny changes, replicating these changes in the lab in order to study them in human stem cells has proven challenging.

Editing scrambled genes in human stem cells may help realize the promise of combined stem cell - gene therapy