Sentences with phrase «in human tissue samples»

This study built on previous research from the Sundrud lab, which showed that when TH17 cells entered the intestine in human tissue samples, they increased the expression of a gene called MDR1.

Not exact matches

There are only a few instances of the polymer being assayed in the milk of women with implants; the concentrations are not elevated over control samples.20 There is no evidence at the present time that this polymer is directly toxic to human tissues; however, concern also exists that toxicity may be mediated through an immunologic mechanism.

More work has to be done on humans as many of the results showed up in mice samples, however in studying the human brains of women who had AD scientists found significantly less male fetal tissue in their brains as in the same of women who did not have AD.

But scientists published in Cell Reports that they've discovered a way to regenerate those cells in mouse, primate and human tissue samples.

West Nile virus and Powassan virus also replicated, or multiplied, more efficiently than the alphaviruses in lab samples of human placental tissue.

Larger biomarker signatures can be detected with technology from CDI Laboratories, which offers microarrays of functional human proteins (over 20,000 on a single array) to test the antibodies present in human liquid biopsy samples, such as blood, serum, plasma, CSF, or tissue lysates.

In cancer research, our goal is to be able to start with a sample of human tissue, extract many cells of interest, and perform genetic analysis upon each of them separately.

The biobank of MedUni Vienna and Vienna General Hospital is a central service facility dedicated to the storage of human tissue, cell material and body fluids for more in - depth diagnosis, academic research projects and clinical tests, as well as working - up samples by way of a medical service.

An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.

Senior author Madhav Dhodapkar, M.D., the Arthur H. and Isabel Bunker Professor of Medicine and Immunobiology, and chief of Hematology, said the study, using tissue and blood samples from humans and mice, shows that chronic stimulation of the immune system by lipids made in the context of inflammation underlies the origins of at least a third of all myeloma cases.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

By using a range of tissue stains, they were able to assess levels of oestrogen receptor (ER), progesterone receptor (PR) and HER2 — human epidermal growth factor — in order to divide the samples into four subtypes.

The interdisciplinary project team is made up of eco - and human toxicologists, physicists, chemists and biologists, and they have just managed to take their first major step forward in achieving their goal: they have developed a method for testing a variety of environmental samples such as river water, animal tissue, or human urine and blood that can detect nanomaterials at a concentration level of nanogram per liter (ppb — parts per billion).

He contacted Susan Murch, a biochemist at the Hospital for Sick Children in Toronto and an expert in finding biomolecules in human tissues, to test the samples in a double - blind study.

These triple - mutant H7 hemagglutinins also successfully latched onto cells in samples of human trachea tissue.

Iwasaki and colleagues next added type I interferon to samples of human placental tissue in dishes.

Dr. Wang plans to continue studying the effects of TNF and IL - 17 on melanocytes, and would like to expand the research to 3D skin models — fabricated samples of tissue in vitro that behave like human skin — that would give a better visual of how the melanin production process is being disrupted by these two cytokines during skin inflammation or wound healing.

The researchers next will turn to analyzing the presence of myoferlin in samples from numerous human tumor types available in an Ohio State tissue bank, which will allow them to compare protein levels in tumors to clinical outcomes for the patients who provided the samples.

The Ogretmen laboratory screened previously reported microarray data sets of several human tumor tissues (metastatic head and neck squamous cell carcinoma, melanoma, and renal cell carcinoma) and showed that, in these samples, only the levels of CerS4 were significantly decreased.

The scientist tested their set - up using frozen human skin cells, segments of pig heart tissue, and sections of pig arteries in volumes almost 20 times larger than previously attempted samples.

They confirmed low levels of miR - 184 expression in human glioma tissue samples and cultured cell lines as well as an increase in the expression of SND1 compared to normal brain tissue.

Historically, animal models — from fruit flies to mice — have been the go - to technique to study the biological consequences of aging, especially in tissues that can't be easily sampled from living humans, like the brain.

When Rupprecht conducts rabies genetic research in China, he finds it is easier to sample brain tissue from deceased humans than from animals.

Studying tissue samples, the researchers found that the nodules in both mice and human were rich in collagen VI.

The use of muscle tissue in post-mortem studies is a novel approach which presents several advantages: first, muscle tissue is the most abundant tissue of the human body and can therefore be sampled easily.

The study of human astrocytes has faced issues related to access (samples of living tissue must be obtained from brain cancer or epilepsy surgeries or fetal tissue) and purification (breaking apart astrocytes away from other cells often killed them and many experiments ended in failure).

With the help of an Egyptology professor, he obtained soft - tissue samples from several Egyptian mummies and, in 1984, coaxed scraps of human genetic material from them.

In Peru, the National Institute of Health's urine samples reflect elemental mercury — mainly vapor inhaled within the past several days — but not methylmercury accumulated in human tissue, which shows up in blood or scalp haiIn Peru, the National Institute of Health's urine samples reflect elemental mercury — mainly vapor inhaled within the past several days — but not methylmercury accumulated in human tissue, which shows up in blood or scalp haiin human tissue, which shows up in blood or scalp haiin blood or scalp hair.

In this collaborative study, Wilkinson and Yanjun Lu, PhD, at the Tongji University in China, and their research teams compared human lung IMT samples and normal lung tissue samples from the same patientIn this collaborative study, Wilkinson and Yanjun Lu, PhD, at the Tongji University in China, and their research teams compared human lung IMT samples and normal lung tissue samples from the same patientin China, and their research teams compared human lung IMT samples and normal lung tissue samples from the same patients.

The researchers analyzed the concentrations of 5,713 different lipids, or fat molecules and their derivatives, present in samples of brain, kidney and muscle tissues taken from humans, chimpanzees, macaques and mice.

The next step will be to explore the effects of lipoxin A4 in samples of human fat tissue, said Borgeson, who has already started this work as a guest researcher at the Sahlgrenska Academy Hospital in Sweden.

By studying these conditions in rats and other animals, Roberts and his colleagues say, researchers can avoid the ethical conundrum involved in forcing active children to refrain from exercise, imposing biopsies and other tissue sampling techniques, or other parts of research that are possible in animals but not in humans.

The SMA field needs all users to actively share feedback regarding general impressions and report any successes or failures, and in particular, if the kits are used to analyze tissue samples other than human PBMCs.

Usually, because of the inaccessibility of brain tissue in living humans, epigenetic studies are carried out using blood samples.

ONE - PARENT SAMPLE SET PARENTAL GUIDANCE RULES: Maternally methylated (red dots) and paternally methylated (blue dots) regions across the human autosomal chromosomes, based on studies of uniparental disomy samplesGENOME RES, 24:554 - 69, 2014 RESEARCHERS Kazuhiko Nakabayashi, Division Chief, Department of Maternal - Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan; David Monk, Principal Investigator, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research ORGANISM Human METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are exprehuman autosomal chromosomes, based on studies of uniparental disomy samplesGENOME RES, 24:554 - 69, 2014 RESEARCHERS Kazuhiko Nakabayashi, Division Chief, Department of Maternal - Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan; David Monk, Principal Investigator, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research ORGANISM Human METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are expreHuman METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are expressed.

Acquire tissue samples and clinical information from as many cases of human prion disease occurring in the United States as possible in order to help monitor the possible occurrence of variant CJD (vCJD) in the USA.

Human spinal cord tissues were obtained from two nine week old, de-identified abortus samples collected in the course of medically prescribed procedures using the Safe - Harbor Method.

The SMA Foundation encourages all users to actively share feedback regarding general impressions and report any successes or failures, and in particular, if the kits are used to analyze tissue samples other than human PBMCs.

The Sanger Institute uses human tissue samples, DNA and RNA donated by the living and the deceased in its research.

Lewis and colleagues from Rockefeller and McGill Universities also screened human tissues from undifferentiated sarcomas and saw the same K36 mutation in 20 percent of the samples.

A sample of her tissue turned out to provide one of the holy grails of mid-century biology: human cells that could survive — even thrive — in the lab.

You should also know that once you «give» i.e. relinquish blood or tissue samples, you no longer «own» them and they can be used in human or animal studies which you may find morally reprehensible or offensive.

It has cryogenic tissue banks with samples of a zillion different things from plants to fungi to bacteria to human sperm and ova and everything in between.