Sentences with phrase «in humans with»

Because intermittent fasting and CR have not been conclusively proven to have beneficial effects in humans with acceptable safety profiles (1), they were not considered to be controls for trials that were identified.

Other neuropsychological symptoms have been seen in humans with severe zinc deficiency.

Sweet potato and cassava can modify cholesterol profile in humans with moderately raised serum cholesterol levels.

STUDY TWO — jamaican scientists tested the effect of cooked tomato supplementation on antioxidant and lipid peroxide levels in humans with type 2 diabetes.

In 2008, a landmark clinical trial in humans with severe cognitive decline was conducted to measure the effects of curcumin.

There is some weak indication, conversely, that vitamin K2 supplementation in humans with poor status improves glucose and insulin metabolism (20).

Steep behavioral changes in humans with respect to certain neurological disorders, such as autism.

This doesn't mean the research has no value, but it's impossible to infer from these results what would happen in humans with any accuracy.

KP: In humans with Alzheimer's disease, getting lost is one of the early symptoms, because remembering how to get somewhere relies on the hippocampus — the first area of the brain to show damage from Alzheimer's pathology.

Shorter SRI treatment or treatment with other antidepressant drugs that do not work in humans with OCD were unsuccessful in reducing the behaviors caused by the drug.

Howard Hughes Medical Institute researchers have produced a genetically altered mouse that exhibits behavioral abnormalities that are strikingly similar to those observed in humans with schizophrenia...

He found that expression was elevated only in beta cells both in humans with type 2 diabetes and in mice that model the disease.

The lab used MRS in a preclinical study of SAPAP3 knockout mice — which model aspects of human obsessive compulsive and related disorders (OCRD)-- to determine whether these mice exhibit neurochemical abnormalities found in humans with OCRD.

In their latest study, researchers at La Jolla Institute for Allergy and Immunology (LJI) used single - cell transcriptome analysis to identify a hitherto unknown precursor for a poorly understood subgroup of killer T cells that is primarily found in humans with chronic viral infections.

While small studies in humans with cognitive impairment have suggested that BHB could improve memory, senior scientist and Buck President and CEO, Eric Verdin MD, says this is the first study in aging mammals which details the positive effects of BHB on memory and lifespan.

The goal was to investigate the ability of J147 to rescue cognitive impairment at a late stage in the disease as an indicator of its potential to rescue cognitive impairment in humans with AD.

Diaphragm muscle fiber function and structure in humans with hemidiaphragm paralysis.

And, as in humans with the condition, cortical thickness and cell organization were preserved.

In 1999, Wolchok received a grant from CRI to conduct a clinical trial of a xenogenic vaccine in humans with melanoma.

Discovered that aberrant patterns of neuronal network activity result in profound anatomical and physiological alterations of learning and memory centers and may contribute to cognitive deficits in humans with AD and related mouse models.

Poly - IC is an investigational drug that has been studied in humans with brain tumors, pancreatic and stomach cancers.

The decreased levels of neutralizing Abs to TMAdV in the researcher (1 ∶ 32) and a family member (1 ∶ 8) relative to those in infected titi monkeys (up to > 1 ∶ 512) are consistent with a recent study showing much higher levels of neutralizing antibodies in chimpanzees than in humans with adenovirus infections, possibly due to more robust adenovirus - specific T - cell responses in humans than in monkeys [45].

The researchers also used viewed the monkeys» brains via magnetic resonance imaging (MRI), which revealed progressive degeneration of the striatum, a region of the brain known to be affected in humans with Huntington's.

Many more years of work remain before this or a similar drug - delivery system can be tested in humans with inoperable bone cancer, the researchers said.

In addition, we have provided recommendations for selecting performance measures and sample sizes to make these assays sensitive to learning and memory deficits in humans with MCI - AD and in mouse models.

Arsenic is a naturally occurring element that can cause organ failure and cancer in humans with prolonged exposure above established health thresholds.

A leading researcher in developmental programming, Challis says this study opens the door to thinking about combating fetal hypoxia in humans with antioxidant therapy.

The results of the study, published last October in the Proceedings of the National Academy of Sciences USA, showed that the flies suffered brain damage and developed many of the same symptoms seen in humans with TBI, including loss of consciousness and coordination and an increased risk of death.

«Although, a atrial cell population is known to be present in humans with comparable properties, it is questionable whether the human heart possesses a similar self - healing ability,» says Stainier.

The data from our two studies provide the evidence we need to begin examining whether similar changes are observed in humans with hyperlipidemia.

When mice exposed to both infection and stress were tested for PPI, however, they responded to the second loud noise with the same intensity even if they had been exposed to a previous tone — the same deficit seen in humans with schizophrenia.

Seeking to address this problem, the authors surmised that inducing gradual hearing loss in mice would parallel the progression of hearing loss in humans with USH3, paving the way to investigate therapies for eventual human benefit.

These findings are consistent with those reported in humans with OCD.

In humans with type 2 diabetes, cells lose the ability to respond to insulin, a hormone that helps regulate the level of sugar in the body.

Previous studies have shown the drug to be effective at spurring new bone growth in mice and in humans with osteoporosis, and a U-M research team believes that it may spur new growth in brittle bone disease patients as well.

This study, for the first time, proved that these cells continually produce this protein in humans with asthma,» states O'Byrne.

Among the susceptible mice, eating or drinking emulsifiers for 12 weeks increased the risk of developing symptoms of colitis — a mouse model of the intestinal inflammation seen in humans with IBD — from 40 % to 80 %.

We have more confidence that we can move toward clinical use of these cells in humans with less concern than we've previously had.»

Previous proteomic studies in humans with brain injuries didn't control for the cause, while results in mice examined the effects of time since injury or repeated injury, but not both.

New studies could include gene therapies in humans with visual problems like macular degeneration or retinal cancer.

When retinal cells die they are much more likely to die in the center of the retina than in the periphery, which the researchers say is exactly what happens in humans with age and the problem with macular degeneration.

More recently, HCQ has shown promise in treating pancreatic cancer patients in ongoing clinical trials; however, its tolerability and effectiveness to stop autophagy in humans with other cancers has not been shown before.

«To date, this type of system has only been used in humans with viral methods of gene delivery, of which the safety profiles are still heavily in debate,» says Betty Tyler, associate professor of neurosurgery at Johns Hopkins.

But Fisher, a member of the team that originally isolated FOXP2 in humans, says that he «would be cautious about concluding» that the new findings represent «a direct parallel with the kinds of speech problems observed in humans with FOXP2 disruption.»

«Another future goal, however, is to use CRISPR - Cas9 for somatic gene therapy in humans with severe diseases,» Klaus Rajewsky pointed out.

Both viruses can cause severe diseases in humans with catastrophic sequelae.

Global gene expression studies found that the LPA - treated mice shared many similar molecular markers as those found in humans with schizophrenia.

Such changes in DNA methylation are also detectable in humans with fatty liver and suggest a similar causal chain.

(We can already do this for dozens of neurons in humans with epilepsy.)

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.