Sentences with phrase «in hypocretin»

I have also personally experienced metabolic distress as a result of fasting, which is evidenced by my interest in hypocretin neurons.

Not exact matches

The hypocretin receptor 2 gene could be the single most important gene in human narcolepsy, says Michael Aldrich, a neurologist and director of the University of Michigan's Sleep Disorders Center.

Using gene mapping techniques, the researchers zeroed in on a mutation in the gene for hypocretin receptor 2.

Hypocretin — which binds to hypocretin receptor 2 — is manufactured in large quantities in some parts of the hypothalamus, an area known to be important in regulatHypocretin — which binds to hypocretin receptor 2 — is manufactured in large quantities in some parts of the hypothalamus, an area known to be important in regulathypocretin receptor 2 — is manufactured in large quantities in some parts of the hypothalamus, an area known to be important in regulating sleep.

First identified in humans early last year, hypocretin receptor 2 was tentatively linked by other researchers to metabolism.

Mignot and his colleagues have begun population studies to see whether hypocretin receptor 2 mutations appear in narcoleptic people.

Meanwhile, pharmaceutical companies are racing to design new narcolepsy drugs based on the discovery of hypocretin's central role in the disorder.

They focused this effect on the hypocretin neurons, which are brain cells in the lateral hypothalamus.

That knowledge, coupled with evidence that narcolepsy in humans might be an autoimmune disorder, has led many researchers to suspect that sufferers have immune systems that are genetically predisposed to attack and destroy hypocretin - producing cells.

In patients with narcolepsy, their immune system destroys the hypocretin cells located in the brain, which are important in order for them to stay awakIn patients with narcolepsy, their immune system destroys the hypocretin cells located in the brain, which are important in order for them to stay awakin the brain, which are important in order for them to stay awakin order for them to stay awake.

Patients lose certain brain cells in the hypothalamus, leading to a deficiency of hypocretin, a molecule that helps regulate the sleep - wake cycle.

Their search turned up a suspect: a piece of a receptor for hypocretin resembles part of the H1N1 influenza nucleoprotein — which binds to the virus genome and plays a key role in its replication.

The result indicates that T cells and HLA, which together regulate much of the body's immune response, gang up in a unique way to destroy narcoleptics» hypocretin cells, the team reports online this week in Nature Genetics.

In the late 1990s, his team discovered that narcoleptics lack hypocretin, a hormone produced by a few brain cells that helps keep people and animals awake.

We also found that a protein involved in modulating the sleep - wake cycle called orexin / hypocretin also influences Aβ levels in the brain.

The laboratory aims are to advance the understanding of the implication of the hypocretin system in cocaine - and alcohol - seeking behavior.

Scientists hypothesized that the problem with S. pyogenes might be «molecular mimicry,» in which a molecular pattern on the bacterium resembles proteins on those hypocretin neurons.

In line with the «molecular mimicry» idea, he also thought he had identified viral proteins that resembled hypocretin.

Mignot and his colleagues identified a spontaneous genetic mutation in those animals that incapacitated a receptor in brain cells for hypocretin.

In late 2013, he published what seemed to be a breakthrough study of patients with narcolepsy, which identified self - reactive T - cells that pursued the hormone hypocretin.

Hypocretin neurons are one way in which intermittent fasting may dysregulate a woman's system.»

Hypocretin neurons are one way in which intermittent fasting may dysregulate a woman's normal hormonal function.

If it is detecting lowered leptin (and other hormone) levels in the blood, it does several things: it up - regulates hunger signalling, it emphasizes sweet foods in doing so (partly why so many disordered eaters struggle with carbohydrates in particular), and it sends activation signals to hypocretin neurons.

And normally, Hypocretin Neurons respond quickly to changes in input.

Ghrelin, which originates in the gut and is known to stimulate appetite, also excites Hypocretin Neurons.

What this means is that Hypocretin Neuron activity is stimulated in part by decreasing levels of leptin in the blood, and that increased leptin levels reduce the level of excitation running through Hypocretin Neurons.

In animals, Hypocretin Neurons serve an important evolutionary function.

they may need leptin infusions to offset the loss of hypocretin neurons in the hypothalamus from years of damage.

Sporadic cases can happen in any breed and is caused by a loss of hypocretin 1 - producing neurons in the hypothalamus.

A genetic basis has been found in Labrador Retrievers and Doberman Pinschers and is due to a mutation involving the hypocretin receptor 2.