Sentences with phrase «in hypomyelination»

When this protective sheath is too thin, as in hypomyelination, the electrical impulses can get lost between nerves and cause the nerves and corresponding muscles to malfunction.

Not exact matches

Although genetic deletion of BACE1 results in abolished amyloid pathology in AD model mice, it also results in neurodevelopmental phenotypes such as hypomyelination and synaptic loss, observed in schizophrenia and autism - like phenotype.

Starting with transplants of human oligodendrocytes in the late 1980s [40], and more recently with populations of human oligodendrocyte progenitor cells isolated from the developing or adult CNS, or from human embryonic stem cells, it has been possible to generate extensive myelination upon transplantation into spinal cord injury or into congenital mouse models of hypomyelination [41]--[48].

Male Springer Spaniel puppies suffer most from hypomyelination because the form of genetic transmission is different in this breed.

Two types of hypomyelination have been described to date, Shaking Pup Syndrome in the English Springer Spaniel, and a second type found primarily in the Weimaraner, but also reported in a single study as being found in Chow Chows.

Congenital hypomyelination is seen as a familial / inherited disorder in Springer Spaniels, Chow Chows, Weimaraners, and Bernese Mountain Dogs, usually with signs developing around 2 — 8 wk of age.

Use of trichlorfon during pregnancy can cause a congenital tremor in piglets due to both cerebellar hypoplasia and hypomyelination.