«One major adaptation is a positive selection for genes involved
in hypoxia response and skeletal development, similar to those expressed in other organisms in high - altitude environments such as Tibet and the Andes,» Dr Subramanian said.
Not exact matches
Arousal and ventilatory
responses to
hypoxia in sleeping infants: effects of maternal smoking
Deficient
hypoxia awakening
response in infants of smoking mothers: possible relationship to sudden infant death syndrome
In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SID
In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor
in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SID
in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons
in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SID
in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30
In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SID
In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors
in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SID
in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from
hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SID
in preterm infants, 32 decreases heart rate variability
in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SID
in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation
in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SID
in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase
in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SID
in blood pressure and heart rate
in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SID
in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes
in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SID
in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.
The production of the HIF - 1 inhibitor occurs
in response to
hypoxia in these cells.
Identification of these genes provides support for previously hypothesized mechanisms of high - altitude adaptation and illuminates the complexity of
hypoxia -
response pathways
in humans.
Several of the identified genes were representative of pathways previously described
in other tissues exposed to
hypoxia, including genes
in the stress
response, apoptotic, proliferation, and synaptic transmission pathways.
Insight into the novel role that NMDA receptors play
in retinal
responses to
hypoxia may be derived from study of the coordinated expression patterns of genes that interact, either directly or indirectly, with the NMDA receptor; namely, the NMDA interactome.
Thus, interactome hubs such as NR1 may exhibit low levels of change
in individual gene expression following
hypoxia, but, based on analysis of interaction networks, are likely to play an important role
in regulating the biologic
response.
He is best known for his ground - breaking discovery of the HIF - 1 (
hypoxia - inducible factor 1) protein, which controls genes
in response to changes
in oxygen availability.
A major aspect of this process is the production of multiple angiogenic cytokines and growth factors
in response to
hypoxia / ischemia, which is mediated by the transcription factor HIF - 1 (
hypoxia - inducible factor 1).
Large - scale transcriptional
response to
hypoxia in Aspergillus fumigatus observed using RNAseq identifies a novel
hypoxia regulated ncRNA.
Compensatory behaviour
in response to sulfide - induced
hypoxia affects time budgets, feeding efficiency, and predation risk.
In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4
In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and
hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role
in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4
in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].
Hypoxia - inducible factor - 1alpha expression predicts a poor
response to primary chemoendocrine therapy and disease - free survival
in primary human breast cancer
Endogenous markers of two separate
hypoxia response pathways (
hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure
in head and neck cancer patients recruited
in the CHART randomized trial
Regulation of mTOR function
in response to
hypoxia by REDD1 and the TSC1 / TSC2 tumor suppressor complex
Lu is a medical student interested
in the role of epigenetic regulation
in high altitude adaptation and
hypoxia response.
Cytoplasmic
in normoxia, nuclear translocation
in response to
hypoxia.
To mimic the
in vitro hypoxic
response in vivo, we developed a xenograft model based on the hypothesis that with increasing xenograft sizes, there will be a parallel increase
in hypoxia due to rapid cell proliferation and restricted blood supply to the xenograft cells.
To assess whether this is occurring within breast cancer cells
in response to
hypoxia - induced activation of ER - α, EGFR signaling was blocked with the inhibitor gefitinib.
AOPCP also modified cardiovascular
responses to
hypoxia, as evidenced by reduced elevations
in heart rate and exaggerated changes
in femoral vascular conductance and mean arterial blood pressure.
Autophagy, a cellular cleaning process, gets activated
in response to certain types of metabolic stress, including nutrient deprivation, growth factor depletion and
hypoxia.
That
response was even better during certain stages of the menstrual cycle
in younger female rats, suggesting female hormones play a role
in the
response to
hypoxia during sleep.
In indigenous Australians and Papua New Guineans, mingling with the Denisovans (the «other Neanderthal,» an ancestral human living primarily in Asia) introduced genes related to «spermatogenesis, fertilization, cold acclimation, circadian rhythm, development of brain, neural tube, face, and olfactory pit, immunity,» as well as «female pregnancy, development of face, lung, heart, skin, nervous system, and male gonad, visual and smell perception, response to heat, pain, hypoxia, and UV, lipid transport, metabolism, blood coagulation, wound healing, aging.&raqu
In indigenous Australians and Papua New Guineans, mingling with the Denisovans (the «other Neanderthal,» an ancestral human living primarily
in Asia) introduced genes related to «spermatogenesis, fertilization, cold acclimation, circadian rhythm, development of brain, neural tube, face, and olfactory pit, immunity,» as well as «female pregnancy, development of face, lung, heart, skin, nervous system, and male gonad, visual and smell perception, response to heat, pain, hypoxia, and UV, lipid transport, metabolism, blood coagulation, wound healing, aging.&raqu
in Asia) introduced genes related to «spermatogenesis, fertilization, cold acclimation, circadian rhythm, development of brain, neural tube, face, and olfactory pit, immunity,» as well as «female pregnancy, development of face, lung, heart, skin, nervous system, and male gonad, visual and smell perception,
response to heat, pain,
hypoxia, and UV, lipid transport, metabolism, blood coagulation, wound healing, aging.»
· Cancer Growth and Spread — Healing Angiogenesis and Metastasis, discussing blood vessel development and growth factors, dysregulation including
hypoxia and other blood supply stress
responses in cancer and other diseases and how cancer cells travel and invade — metastasis via the complex tumour microenvironment — TME — comprised of immune cells, cytokines, growth factors, reactive oxygen species (ROS) and cancer - associated fibroblast (CAF);