Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed
in a hypoxic environment.
However,
in a hypoxic environment, it is activated and initiates a series of events to combat physiological effects of low oxygen.
Not exact matches
Some autopsy data shows that infants of smokers have signs of established
hypoxic - ischemic cellular injury
in the brain and the heart which probably occurred
in antenatal life, may have been caused by suboptimal placental function and may have been sub-clinical, but if the baby continues to be
in a vulnerable
environment exposed to post-natal passive smoking, this could affect autonomic nervous system function and lead to poor temperature control, and poor heart rate and respiration control.
To enable them to survive, adapt and grow
in the low - oxygen or «
hypoxic»
environments, tumors contain increased levels of a protein called Hypoxia - inducible factor 1 (HIF - 1).
Band led a previous analysis of gene expression
in blind mole - rats living
in low - oxygen (
hypoxic)
environments.
«Our results are consistent with the oxygen levels shown to influence blue crab behaviors
in both field and laboratory settings,» says Brill, and «support the idea that blue crabs are well adapted to the
hypoxic conditions occurring
in the estuarine
environments they occupy.»
Lead author Rich Brill, a fishery biologist with NOAA's National Marine Fisheries Service and adjunct faculty at VIMS, says «The notion that blue crabs are relatively intolerant of oxygen - poor waters was counterintuitive, because this species often occupies estuarine
environments that can become
hypoxic even
in the absence of human activities.»
«The hypothesis that higher intake of plant foods is beneficial to human health because this increases antioxidant defence against oxidative damage is logical
in evolutionary terms, especially when we consider the relatively
hypoxic environment in which humans may have evolved.
In fact, prevention of excessive swelling is important because fluid that has escaped into the tissues from excessive swelling can create a low oxygen (
hypoxic)
environment that can lead to additional tissue damage and delay healing.