Sentences with phrase «in hypoxic regions»
«The IMM teams showed clearly that the gene was switched on only in hypoxic regions,» says Sue Kingsman, the research director of Oxford BioMedica.
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When oxygen is scarce, however, HIF - 1α starts to accumulate and turns on the expression of a host of genes that assist in promoting and increasing oxygen delivery to hypoxic regions.
Furthermore, these results also have an important prognostic value — the positioning of macrophages in hypoxic tumor regions would be an indication of a poor prognosis, while the localization of macrophages in normoxic regions of the tumor could predict a better disease outcome.
Consequently, they discovered that by blocking Nrp1, macrophages were no longer able to migrate inside hypoxic regions in the tumor.
As the duration and extent of hypoxic areas is predicted to increase in coastal regions, it is likely that some species will be exposed chronically throughout their life cycle.
Importantly, NSCs can target breast cancer metastasis in the brain [9] and can penetrate deep and hypoxic regions of solid tumors [7].
Cancer stem cells (CSCs) in the hypoxic BM regions are blamed for the incurability of MM, because CSCs are often resistant to drugs currently used against BM cancers (including proteasome inhibitors and immunomodulatory agents).
The hypoxic zone forms in the middle of the most important commercial and recreational fisheries in the coterminous United States and could threaten the economy of this region of the Gulf.