Not exact matches
The introduction of infant formula
to babies» diets changes the infants» gut microbiome, thus affecting the
response of the infant
immune system
to pathogens.47 - 51 A greater amount of natural - killer cells, suggesting a more mature
immune system, have been found
in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51,
in breastfed infants than
in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51,
in formula - fed infants.52
In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51,
In addition, pH level
in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51,
in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death
in tumor cells.51,
in tumor cells.51, 53
An
immune response, triggered by foreign neural stem cells, could actually help attack
tumors, says Evan Snyder, a stem cell biologist at Sanford Burnham Prebys Medical Discovery Institute
in San Diego, California, and one of the early pioneers of the idea of using stem cells
to attack
tumors.
«This research represents a big step forward
in understanding why some
tumors are more aggressive than others and being able
to predict rationally which neoantigens will be the most effective at stimulating an
immune response,» said Dr. Balachandran, a member of the David M. Rubenstein Center for Pancreatic Cancer Research at MSK, and corresponding author of the companion study
in Nature.
In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapie
In addition
to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of
tumor immune biology as well as mechanisms associated with
immune response and
immune escape
in cancer patients, with the intent of generating rational strategies for the creation of combination therapie
in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.
C. novyi is really a two - pronged weapon against cancer: It germinates
in tumors and releases cancer - killing enzymes, and it may also trigger an
immune response similar
to Coley's Toxin.
«It suggests there's a common mechanism
in both species for susceptibility
to tumor progression that may involve subversion of the host
immune response.
The personalized vaccine is made from patients» own
immune cells, which are exposed
in the laboratory
to the contents of the patients»
tumor cells, and then injected into the patients
to initiate a wider
immune response.
The team also compared the animals»
responses to the therapy's effects
in laboratory cell samples and found that
in vitro studies did not predict how well the viral therapy and
immune response would fight
tumor cells
in vivo.
«The effective
immune response didn't happen
in every
tumor model we tested, so we still need
to figure out exactly what triggered the
tumor shrinkage and how
to predict which
tumors will shrink
in response to virotherapy,» said Leddon, who is also working toward her medical and doctoral degrees at the University of Cincinnati.
Less suppression of the
immune response and less blood vessel formation
in the
tumor leads
to less
tumor growth.
Drugs like pembrolizumab boost the
response in tumors where
immune cells are present but don't work
in tumors where there is no
immune response to boost.
Principal Investigator John Morris, MD, clinical co-leader of the Molecular Therapeutics and Diagnosis Program for the CCC, co-leader of the UC Cancer Institute's Comprehensive Lung Cancer Program, professor
in the division of hematology oncology at the UC College of Medicine and UC Health medical oncologist, says a number of antitumor vaccines have shown promise for causing
immune responses against
tumor antigens
to improve patient outcomes.
In addition to monitoring the response of injected melanoma tumors, we are also measuring the boost in the anti-tumor immune cells of patients after injection,» explained Amod A. Sarnaik, M.D., assistant member of Moffitt's Cutaneous Oncology Progra
In addition
to monitoring the
response of injected melanoma
tumors, we are also measuring the boost
in the anti-tumor immune cells of patients after injection,» explained Amod A. Sarnaik, M.D., assistant member of Moffitt's Cutaneous Oncology Progra
in the anti-tumor
immune cells of patients after injection,» explained Amod A. Sarnaik, M.D., assistant member of Moffitt's Cutaneous Oncology Program.
Now, scientists have modified Salmonella bacteria
to trigger a particularly powerful
immune response against human cancer cells implanted
in mice, shrinking the
tumors and — for the first time — preventing them from metastasizing.
In this study, we examined the effectiveness of a vaccination targeting
tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability
to up - regulate (or increase)
immune responses to tumor antigens,» Morris says.
To accomplish this, they had to thread a needle in immune function, shrinking tumors without triggering unwanted autoimmune response
To accomplish this, they had
to thread a needle in immune function, shrinking tumors without triggering unwanted autoimmune response
to thread a needle
in immune function, shrinking
tumors without triggering unwanted autoimmune
responses.
The light - sensitive cells and nanoparticles, called opto - CRAC, were then delivered with the
tumor antigen surrogate ovalbumin
to mice with melanoma
tumors in their lymph nodes
to see if an
immune response could be activated
to target cancer cells.
A combination of iron - oxide nanoparticles and an alternating magnetic field, which together generate heat, have activated an
immune system
response to tumors in mice according
to an accepted manuscript by Dartmouth - Hitchcock Norris Cotton Center researchers
in the journal Nanomedicine: Nanotechnology, Biology and Medicine released online on February 24, 2014.
Mechanistic studies showed that IFN increases antitumor
immune responses by enhancing antigen presentation
to T cells by dendritic cells present
in the
tumor microenvironment.
Dr. Gnjatic's research focuses on human antigen - specific
immune responses to tumor antigens,
in an attempt
to define new targets for the development of cancer immunotherapies, assess the efficacy of these immunotherapies, and learn why they may fail.
The systemic
response to surgery triggers the outgrowth of distant
immune - controlled
tumors in mouse models of dormancy
What's more, IL - 33 and the DNA vaccine augmented immunological
responses in both CD4 helper T cells and CD8 killer T cells, with a large proportion of CD8 killer T cells demonstrating a further improvement
in the ability of DNA vaccines
to drive the
immune system
to kill
tumor cells
in animals.
For instance, a
tumor influences the expression of genes
in immune system cells that are involved
in the body's
response to cancer.
Antibodies only bind
to target cells Peptide antibodies developed by Kwak and co-discoverer, Hong Qin, Ph.D., assistant professor of Lymphoma / Myeloma, wipe out MDSCs
in the blood, spleen and
tumor cells of mice without binding
to other white blood cells or dendritic cells involved
in immune response.
Scientists have found a way
to target elusive cells that suppress
immune response, depleting them with peptides that spare other important cells and shrink
tumors in preclinical experiments, according
to a paper published online by Nature Medicine.
While this approach has had some clinical success,
in most cases, the
immune response resulting from dendritic cell vaccines is short - lived and not robust enough
to keep
tumors at bay over the long run.
In cases where there are lots of T cells in the vicinity of a tumor, or where tumor cells have undergone large numbers of mutations, which creates additional targets for immune sentries, T cells will signal a full - fledged immune response to the cance
In cases where there are lots of T cells
in the vicinity of a tumor, or where tumor cells have undergone large numbers of mutations, which creates additional targets for immune sentries, T cells will signal a full - fledged immune response to the cance
in the vicinity of a
tumor, or where
tumor cells have undergone large numbers of mutations, which creates additional targets for
immune sentries, T cells will signal a full - fledged
immune response to the cancer.
The Johns Hopkins team tested ImmunoMap's ability
to correlate
immune responses on receptor sequencing data from T - cells
in the
tumors of 34 patients with cancer enrolled
in a nationwide clinical trial of the immunotherapy drug nivolumab.
Oncologists have long known that
in rare cases, after patients receive radiation therapy
to shrink a
tumor, the
immune system will mount an aggressive
response that wipes out not only the
tumor, but metastases throughout the body that hadn't been treated with the radiation.
They used the gene - editing CRISPR / Cas9 technique
to sift the genomes of melanoma cells for changes that made
tumors resistant
to being killed by
immune T cells, which are the main actors
in the
immune system
response against infections and cancer cells.
During inflammatory
responses due
to infection, trauma, or cancer, the body's
immune system becomes highly activated
in an attempt
to fend off invading organisms, foreign bodies, or
tumor cells.
Each of these molecules plays a critical role
in enhancing the overall
immune response to the
tumor.
These types of engineered
tumors are much more difficult
to treat than human
tumors implanted
in mice, because they suppress the
immune response against them.
Last year, Wittrup showed that delivering antibodies and IL - 2, a signaling molecule that helps
to boost
immune responses, could halt the growth of aggressive melanoma
tumors in mice for as long as the treatment was given.
In 2008, he joined the group of Caetano Reis e Sousa at the Cancer Research UK (CRUK) London Research Institute and later joined the Francis Crick Institute, where he was awarded Marie Curie and EMBO long - term postdoctoral fellowships
to investigate innate
immune receptors and signaling pathways that trigger dendritic cell activation and drive T - cell
responses against viruses or
tumors.
In experiments in animals, researchers from the University of Michigan Medical School showed that adding rapamycin to an immunotherapy approach strengthened the immune response against brain tumor cell
In experiments
in animals, researchers from the University of Michigan Medical School showed that adding rapamycin to an immunotherapy approach strengthened the immune response against brain tumor cell
in animals, researchers from the University of Michigan Medical School showed that adding rapamycin
to an immunotherapy approach strengthened the
immune response against brain
tumor cells.
This did induce an
immune response but only led
to tumor rejection
in one - quarter of the animals.»
These latter two cell types can mount effective
immune responses to viruses and
tumors; whereas, exhausted T cells fail and memory T cells,
in particular, for long - lasting durable effects.
For nearly 20 years, doctors have used cyclosporine
to dull the
immune response, which would otherwise reject a transplant — a strategy that carries with it a 100-fold increase
in tumor risk among these patients compared
to healthy individuals.
By analyzing a dataset of human
immune cells stimulated with interferon — a signaling protein created
in response to pathogens or
tumor cells — the team could precisely identify which genes were switched on
in each of 13 responding cell types.
A T - cell marker panel that can identify subsets of
tumor - associated T - cells allows scientists
to identify and target subpopulations of T - cells playing unique roles
in the
immune response against a
tumor.
«Our results clearly demonstrate a significant, although unexpected, role for specific gut bacteria
in enhancing the
immune system's
response to melanoma and possibly many other
tumor types,» said study director Thomas Gajewski, MD, PhD, professor of medicine and pathology at the University of Chicago.
A personal cancer treatment vaccine that targets distinctive «neoantigens» on
tumor cells has been shown
to stimulate a potent, safe, and highly specific
immune anti-
tumor response in melanoma patients, report scientists from Dana - Farber Cancer Institute and the Broad Institute of MIT and Harvard.
Using transplantable
tumor models expressing antigen
in an inducible manner or spontaneous
tumor models expressing nominal antigens, we try
to decipher whether the
tumor is ignored or leads
to deletion, anergy or class switch of the specific
immune response or generate suppressor T cells.
We are particularly interested
in leverage our interdisciplinary expertise
in polymer chemistry, nanomedicine, drug delivery and immunobiology
to innovate new approaches
to modulate the
tumor microenvironment and enhance cellular
immune responses to cancer vaccines.
We chose this model because 1) it more closely recapitulates features of human pancreatic cancer than do s.c. - implanted
tumors, 2) it can be used
in immunocompetent mice
to permit assessment of
immune responses, and 3) the cells grow
in vivo with predictable kinetics (34).
Our PDX models and other next - generation cancer modeling platforms allow you
to address critical questions
in oncology research, such as unexplained drug resistance, drug efficacy, genomic heterogeneity
in solid
tumor, and the role of the
immune system
in drug
response.
Dr. Levitsky: My organization within Roche, Pharma Research and Early Development (pRED), has invested
in antibody engineering, not only for use of monoclonal antibodies
in the established ways of delivering cell - killing agents
to tumors or interrupting cell signalling pathways, but also as ways
to engage and manipulate the
immune system's
response to tumors.
Melanoma is a
tumor that is recognized by the immunological system and mechanisms leading
to an anti-
tumor immune response of potential value
in the adjuvant setting.
The researchers tested whether stromal
tumor infiltrating lymphocytes (TILs) and other
immune cells might predict
responses to therapy
in a set of 30 HER2 - positive breast cancer tissues treated with TCHP (26 patients) or with TCH without pertuzumab (4 patients).