Sentences with phrase «in immunocompetent mice»

While this difference was largely strain - dependent, it also reflected the fact that in the Rag2 − / − γc − / − mice hematopoietic space was greater than in the immunocompetent mice.

In ongoing experiments, we are studying whether natural killer cells play a role in the engraftment of HPCs in immunocompetent mice.

A combination of our current protocol with a myeloablative treatment approach might further improve HPC engraftment in immunocompetent mice.

Although a number of instances of successful long - term engraftment of ES - derived HPCs have been published, no data are available yet on engraftment of these cells in immunocompetent mice.

This study focuses on the engraftment of HPCs in immunocompetent mice and proposes a strategy that could exploit available human ES cell lines to improve organ transplantation.

Such virus variants selectively suppress LCMV - specific CTL responses and cause persistent infections in immunocompetent mice.

In striking contrast, wild - type LCMV Armstrong, from which these variants were generated, induces a potent CTL response in immunocompetent mice and the LCMV infection is rapidly cleared.

We chose this model because 1) it more closely recapitulates features of human pancreatic cancer than do s.c. - implanted tumors, 2) it can be used in immunocompetent mice to permit assessment of immune responses, and 3) the cells grow in vivo with predictable kinetics (34).

Not exact matches

To sidestep the shortcomings of currently used cancer models, the Salk team harnessed the power of lentiviral vectors to infect nondividing as well as dividing cells and ferry activated oncogenes into a small number of cells in adult, fully immunocompetent mice.

Although a number of groups have already looked at the engraftment of ES - derived HPCs in Rag2 − / − γc − / − mice, there are no reports on HPC engraftment in either syngeneic or allogenic immunocompetent mice.

This is the first time that in vitro generated HPCs were transplanted and used to establish long - term engraftment in allogeneic immunocompetent mice, resulting in the protection of donor type grafts from immunological rejection.

Although we were able to now detect more distinct T and B cell populations in the transplanted immunocompetent MRL and 129SvJ mice, the numbers of lymphoid cells remained far less than would be expected after bone marrow transplantation.

Experimental animal studies have shown that Borrelia burgdorferi, the agent of Lyme borreliosis, consistently establishes persistent infections in a variety of immunocompetent hosts, including laboratory mice [1], white - footed mice (Peromyscus leucopus)[2], [3], [4], rats [5], hamsters [6], guinea pigs [7], gerbils [8], dogs [9], and nonhuman primates, including rhesus macaques (Macaca mulatta)[10] and baboons (Papio spp.)[11].