Integrated analysis of isopentenyl pyrophosphate (IPP) toxicity
in isoprenoid - producing Escherichia coli.
Not exact matches
Previous work also suggested synergistic impact of
isoprenoids on tumor growth, a finding remaining to be confirmed
in prostate cancer.
This tumor - targeted action of
isoprenoids was manifested
in animal studies showing no toxicity of
isoprenoids at tumor - suppressive doses (reviewed by Mo & Elson, Exp Biol Med, 2004, 229:567 - 85).
Isoprenoid - mediated suppression of HMG CoA reductase
in tumors was previously correlated to growth arrest; the latter was attenuated by supplemental mevalonate.
Specifically, she wants to understand the role that specific metabolites called
isoprenoids play
in the early stages of development.