Sentences with phrase «in kidney cells»

But the study their claim is based on is an in vitro trial in kidney cells.

Sorbitol is a sugar which accumulates in kidney cells, nerve cells, and cells in the eyes of type 2 diabetes patients.

Interestingly, ActD - induction of p53 expression was much faster in liver cells than in kidney cells.

Using postmortem kidneys donated from generous Medalists, the Joslin team looked at the levels of thousands of proteins expressed in kidney cells that help to filter blood, and compared the results for Medalists with and without kidney disease.

The authors report that when the inactive halves of DAM attached to Notch and its partners rejoined, they reactivated and allowed the marking of the bound DNA in kidney cells.

Not exact matches

The cancerous cells win out over the healthy blood cells in the bone marrow, which in turn leads to kidney problems when the cancer cells make abnormal proteins instead of antibodies.

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

When the CEO's cell phone bill each month was more than the amount she gave out in Kidney funds to patients.

Propylene glycol, in particular, has been known to inhibit cell growth and has been linked to kidney damage and liver abnormalities.

It may stunt the physical and mental growth of your baby and can cause considerable damage to the developing lungs, brain, liver, nervous system, kidneys and red blood cells in your baby.

The researchers detected this SMN long noncoding RNA, or lnc - RNA (pronounced «link RNA») for short, in human embryonic kidney cells, brain cell samples and neurons derived from the stem cells of healthy people and those with spinal muscular atrophy type I and II.

Dunsby and colleagues used it to measure glucose uptake, indicated by a fluorescent biosensor, in multicellular kidney cell spheroids.

Fussenegger created his biological calculator by engineering an embryonic kidney cell to respond to two different chemicals: erythromycin (an antibiotic) and phloretin (a compound found in apple trees).

Stem cells in babies» urine seem to help regenerate kidney tissue, protecting it from toxic drugs and could pep up organs for transplantation

Endocytosis of Frizzled 4 (Fz4) in human embryonic kidney 293 cells was dependent on added Wnt5A protein and was accomplished by the multifunctional adaptor protein β - arrestin 2 (βarr2), which was recruited to Fz4 by binding to phosphorylated Dvl2.

His group assessed the animals for changes in body weight as well as potential toxicity to the liver, kidney, and blood cells — none of which was observed.

Cells may migrate through the placenta between the mother and the fetus, taking up residence in many organs of the body including the lung, thyroid, muscle, liver, heart, kidney and skin.

Remarkably, given the complexity of the kidney, the cells differentiated into exactly those required in the different compartments of the organ.

Small amounts of glycogen are found in the kidneys, and even smaller amounts in certain glial cells in the brain and white blood cells.

In addition, monkeys» kidney cells do not normally support the growth of HIV.

In their latest study, they tested compounds against cells from nine different types of human cancer, including common types affecting blood, colon, breast, prostate, ovaries, kidneys, and lungs.

Using VCell, a biologist can predict what happens when a certain drug encounters a filtration cell in the kidney, for example, or how a hemoglobin molecule in a red blood cell deals with a spike in carbon dioxide.

Both vaccines were based on live, weakened strains of polio virus grown in monkeys» kidney cells.

Both of these cell layers act as a barrier to small molecules and ions that protects the organs and enables specialized functions, such as absorption in the intestine or urine secretion in the kidney.

The remainder are absorbed by other cells, including those in the liver, spleen and kidneys.

The scientists in London got the same result in a similar experiment using mammalian kidney cells, showing that healthy and mutant cells compete directly against each other in mammals.

Two years ago, he and his colleagues reported in Aging Cell that cutting the calories ingested by mice by 30 % for up to 4 weeks protected the rodents» kidneys when their blood supply was cut off and then restored.

The problem is that the body breaks down and eliminates real hemoglobin that is not protected by red blood cells, a process that can be toxic to the kidneys, constrict blood vessels (resulting in hypertension), and cause inflammation.

They will have to address side effects such as the flulike symptoms and the kidney failure that occurred in one patient due to all the dead cells the body had to cleanse from the blood.

The researchers then used a 3 - D cell culture system to coax their mutant and healthy hPSCs down the differentiation pathway into becoming kidney progenitor cells and finally the proximal tubule cells found in kidney nephrons.

And in 2010, a 46 - year - old woman developed multiple tumours in her kidney after having her own bone marrow stem cells injected at a private clinic in an attempt to treat her kidney failure.

Scientists report today that artificial blood vessels made using a person's own skin cells work well in patients receiving kidney dialysis.

In the longer term, these methods could hasten progress toward replacing a damaged or diseased kidney with tissue derived from a patient's own cells.

In kidney cancer, the over-expressed NPTX2 protein is secreted from the cell and then attaches itself to GluR4 on the kidney cancer cell membrane.

«Just one transplant of the human EPO - producing cells treated kidney anaemia in mice, keeping their haemoglobin levels in the normal range for the remaining 7 - month lifespan of the animals,» says Kenji Osafune, of Kyoto University in Japan, who led the team.

In previous studies, researchers have successfully differentiated stem cells into heart, liver, pancreas or nerve cells by adding certain chemicals, but kidney cells have proved challenging.

To date, the researchers have tested the function of their activation - ready sensor in cell culture of human kidney and cancer cells.

To demonstrate the capabilities of SpDamID in the current study, the authors analyzed Notch - mediated transcriptional activation in mouse kidney progenitor cells (mK4 cells).

«We have converted skin cells to stem cells and developed a highly efficient process to convert these stem cells into kidney structures that resemble those found in a normal human kidney.

Research in the laboratory of Rebecca Wingert, the Gallagher Family Associate Professor of Adult Stem Cell Research in the Department of Biological Sciences at the University of Notre Dame, has confirmed the key role of a certain small molecule in the development of kidney structures in zebrafish, a widely used model for human kidneys.

Obesity suppresses an important cellular process that prevents kidney cell damage, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

«Virtual tissue technology reveals new drug target in polycystic kidney disease: Advanced computer simulations show that failures of cell adhesion and inhibition cause two types of kidney cyst formation.»

As fat cells bulge, the body tries to store glucose in other tissues, including the liver, kidney, heart, muscles, and blood vessels, where the rotting process takes hold.

It reveals that errors in how cells stick together give rise to two forms of kidney cysts.

«This is a unique platform to study interactions between drugs and cells or tissues, specifically in the kidney, where current models were lacking,» said Sakolish.

«This is the first study to show the actual cell behaviors caused by mutations in genes causally linked to polycystic kidney disease, an important new step in the path towards treatment,» said Dr. Robert L. Bacallao, associate professor of medicine at the IU School of Medicine in Indianapolis.

After running the simulations at IU Bloomington, Bacallao confirmed the cyst growth predictions seen in the virtual cysts in experiments using real human cells cultivated from polycystic kidneys from patients at the IU School of Medicine.

The use of stem cells in the treatment of feline chronic kidney disease, however, has been the exception.

Under pressure to name several possible future perspectives, Bente Vilsen mentions that the discovery of the electroneutral sodium - potassium pump also makes it possible to explore what an inability to produce current means for the development of the cells and the occurrence of diseases in e.g. the brain and kidneys, where the sodium - potassium pump plays a crucial role.

The best results were seen in lung endothelial cells, but the particles also successfully delivered RNA to the kidneys and heart, among other organs.